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Partha Bhattacharjee

TitleFaculty, Department of Biology
Faculty RankAssociate Professor
InstitutionXavier University of Louisiana
AddressXavier University of Louisiana
1 Drexel Drive
New Orleans LA 70125
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    Other Positions
    TitleAdjunct Faculty
    InstitutionLSU Health Sciences Center

    Collapse Biography 
    Collapse awards and honors
    2007 - 2008Translational Research Award, LSU Health Sciences Center
    2008 - 2008R21, NIH/National Eye Institute
    2011 - 2011NCF Excellence Award for Research, Xavier University of Louisiana

    Collapse Overview 
    Collapse overview
    Since 2002, I am engaged in vision research and starting 2006, I became an independent researcher at the LSU Eye Center of Excellence. In the year 2008, while at Xavier, I was awarded NIH/R21 grant from NEI and engaged in the discovery of a peptide against inflammation and neovascularization in cornea of mouse and rabbit eyes. We, now have an approved patent of this anti-inflammatory and anti-angiogenic peptide. Subsequently, I developed interest in the area of anti-angiogenesis with this peptide in VEGF (vascular endothelial growth factor)-induced angiogenesis in rabbit eye model (published in PLoS ONE, 2011). Further we looked in to the molecular events blocked by this anti-angiogenic peptide that inhibits ECM(extracellular matrix) degradation of retina in vitro and in vivo (Published in PLoS ONE, 2012). Now, my research is focused in identifying specific receptor-ligand interaction in the retinal pathology. We choose to study retinopathy induced by diabetes mellitus/hyperglycemia. I have been using Xavier Vivarium and type 1 and type 2 diabetic mice models. I am a trained virologist (Ph.D. in virology) and developed expertise in cloning and characterization of clones while working Kansas State University and LSU School of Medicine (Published in VIROLOGY and Journal of Virology). My expertise in virology and animal model of eye research suitably poised to accomplish the current project of phage-display peptide inhibitor of diabetic retinopathy. My research engages meritorious undergraduate student with bacteriophage/phage research.

    Collapse Research 
    Collapse research activities and funding
    R21EY019144     (BHATTACHARJEE, PARTHA S)Sep 30, 2009 - Sep 29, 2012
    A novel peptide therapy for treatment of herpetic stromal keratitis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Xian P, Reid JS, Hyer EJ, Sampson CR, Rubin JI, Ades M, Asencio N, Basart S, Benedetti A, Bhattacharjee PS, Brooks ME, Colarco PR, da Silva AM, Eck TF, Guth J, Jorba O, Kouznetsov R, Kipling Z, Sofiev M, Perez Garcia-Pando C, Pradhan Y, Tanaka T, Wang J, Westphal DL, Yumimoto K, Zhang J. Current state of the global operational aerosol multi-model ensemble: An update from the International Cooperative for Aerosol Prediction (ICAP). Q J R Meteorol Soc. 2019 Sep; 145(Suppl 1):176-209. PMID: 31787783.
    2. Zhou Q, Yu B, Anderson C, Huang ZP, Hanus J, Zhang W, Han Y, Bhattacharjee PS, Srinivasan S, Zhang K, Wang DZ, Wang S. LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus. Elife. 2019 02 11; 8. PMID: 30741632.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    3. Zhao F, Anderson C, Karnes S, Zhou Q, Ma J, Jin ZG, Bhattacharjee PS, Wang S. Expression, regulation and function of miR-126 in the mouse choroid vasculature. Exp Eye Res. 2018 05; 170:169-176. PMID: 29501382.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Hossain A, Tauhid L, Davenport I, Huckaba T, Graves R, Mandal T, Muniruzzaman S, Ahmed SA, Bhattacharjee PS. LRP-1 Pathway Targeted Inhibition of Vascular Abnormalities in the Retina of Diabetic Mice. Curr Eye Res. 2017 04; 42(4):640-647. PMID: 27442082.
      Citations: 1     Fields:    Translation:AnimalsCells
    5. Hossain A, Heron D, Davenport I, Huckaba T, Graves R, Mandal T, Muniruzzaman S, Wang S, Bhattacharjee PS. Protective effects of bestatin in the retina of streptozotocin-induced diabetic mice. Exp Eye Res. 2016 08; 149:100-106. PMID: 27344955.
      Citations: 1     Fields:    Translation:Animals
    6. Muniruzzaman S, McIntosh M, Hossain A, Izumori K, Bhattacharjee PS. A novel rare sugar inhibitor of murine herpes simplex keratitis. J Pharmacol Sci. 2016 Jun; 131(2):126-30. PMID: 27262904.
      Citations:    Fields:    Translation:AnimalsCells
    7. Lu CH, da Silva A, Wang J, Moorthi S, Chin M, Colarco P, Tang Y, Bhattacharjee PS, Chen SP, Chuang HY, Juang HH, McQueen J, Iredell M. The implementation of NEMS GFS Aerosol Component (NGAC) Version 1.0 for global dust forecasting at NOAA/NCEP. Geosci Model Dev. 2016; 9(5):1905-1919. PMID: 29652411.
    8. Moniruzzaman M, Hossain MS, Bhattacharjee PS. Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn. J Ethnopharmacol. 2016 Jun 20; 186:205-208. PMID: 27060632.
      Citations: 1     Fields:    Translation:Animals
    9. Bhattacharjee PS, Zaitchik BF. Perspectives on CMIP5 model performance in the Nile River headwaters regions. Int J Climatol. 2015 11 30; 35(14):4262-4275. PMID: 27656043.
    10. Hill JM, Stern EM, Bhattacharjee PS, Malamud D, Clement C, Rodriguez P, Lukiw WJ, Ochoa AC, Foster TP, Velasco C, McFerrin HE. The antimicrobial agent C31G is effective for therapy for HSV-1 ocular keratitis in the rabbit eye model. Antiviral Res. 2013 Oct; 100(1):14-9. PMID: 23860013.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Bhattacharjee PS, Huq TS, Potter V, Young A, Davenport IR, Graves R, Mandal TK, Clement C, McFerrin HE, Muniruzzaman S, Ireland SK, Hill JM. High-glucose-induced endothelial cell injury is inhibited by a Peptide derived from human apolipoprotein E. PLoS One. 2012; 7(12):e52152. PMID: 23284911.
      Citations: 10     Fields:    Translation:AnimalsCells
    12. Webre JM, Hill JM, Nolan NM, Clement C, McFerrin HE, Bhattacharjee PS, Hsia V, Neumann DM, Foster TP, Lukiw WJ, Thompson HW. Rabbit and mouse models of HSV-1 latency, reactivation, and recurrent eye diseases. J Biomed Biotechnol. 2012; 2012:612316. PMID: 23091352.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    13. Hill JM, Nolan NM, McFerrin HE, Clement C, Foster TP, Halford WP, Kousoulas KG, Lukiw WJ, Thompson HW, Stern EM, Bhattacharjee PS. HSV-1 latent rabbits shed viral DNA into their saliva. Virol J. 2012 Sep 28; 9:221. PMID: 23021094.
      Citations: 10     Fields:    Translation:AnimalsCells
    14. Al-Dujaili LJ, Clerkin PP, Clement C, McFerrin HE, Bhattacharjee PS, Varnell ED, Kaufman HE, Hill JM. Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated? Future Microbiol. 2011 Aug; 6(8):877-907. PMID: 21861620.
      Citations: 26     Fields:    Translation:HumansCells
    15. Clement C, Bhattacharjee PS, Kumar M, Foster TP, Thompson HW, Hill JM. Upregulation of mouse genes in HSV-1 latent TG after butyrate treatment implicates the multiple roles of the LAT-ICP0 locus. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1770-9. PMID: 20881297.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Kennedy DP, Clement C, Arceneaux RL, Bhattacharjee PS, Huq TS, Hill JM. Ocular herpes simplex virus type 1: is the cornea a reservoir for viral latency or a fast pit stop? Cornea. 2011 Mar; 30(3):251-9. PMID: 21304287.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    17. Hobden JA, Kumar M, Kaufman HE, Clement C, Varnell ED, Bhattacharjee PS, Hill JM. In vitro synergism of trifluorothymidine and ganciclovir against HSV-1. Invest Ophthalmol Vis Sci. 2011 Feb; 52(2):830-3. PMID: 20861476.
      Citations: 2     Fields:    Translation:AnimalsCells
    18. Clement C, Capriotti JA, Kumar M, Hobden JA, Foster TP, Bhattacharjee PS, Thompson HW, Mahmud R, Liang B, Hill JM. Clinical and antiviral efficacy of an ophthalmic formulation of dexamethasone povidone-iodine in a rabbit model of adenoviral keratoconjunctivitis. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):339-44. PMID: 20702820.
      Citations: 16     Fields:    Translation:AnimalsCells
    19. Bhattacharjee PS, Huq TS, Mandal TK, Graves RA, Muniruzzaman S, Clement C, McFerrin HE, Hill JM. A novel peptide derived from human apolipoprotein E is an inhibitor of tumor growth and ocular angiogenesis. PLoS One. 2011 Jan 06; 6(1):e15905. PMID: 21253017.
      Citations: 13     Fields:    Translation:HumansAnimals
    20. Lukiw WJ, Cui JG, Yuan LY, Bhattacharjee PS, Corkern M, Clement C, Kammerman EM, Ball MJ, Zhao Y, Sullivan PM, Hill JM. Acyclovir or Aß42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. Neuroreport. 2010 Oct 06; 21(14):922-7. PMID: 20683212.
      Citations: 46     Fields:    Translation:HumansCells
    21. Kumar M, Kaufman HE, Clement C, Bhattacharjee PS, Huq TS, Varnell ED, Thompson HW, Hill JM. Effect of high versus low oral doses of valacyclovir on herpes simplex virus-1 DNA shedding into tears of latently infected rabbits. Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4703-6. PMID: 20393107.
      Citations: 7     Fields:    Translation:AnimalsCells
    22. Shah SS, Denham LV, Elison JR, Bhattacharjee PS, Clement C, Huq T, Hill JM. Drug delivery to the posterior segment of the eye for pharmacologic therapy. Expert Rev Ophthalmol. 2010 Feb 01; 5(1):75-93. PMID: 20305803.
    23. Bhattacharjee PS, Neumann DM, Hill JM. A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits. Curr Eye Res. 2009 Feb; 34(2):99-102. PMID: 19219680.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    24. Clement C, Bhattacharjee PS, Kaufman HE, Hill JM. Heat-induced reactivation of HSV-1 in latent mice: upregulation in the TG of CD83 and other immune response genes and their LAT-ICP0 locus. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2855-61. PMID: 19151393.
      Citations: 9     Fields:    Translation:AnimalsCells
    25. Clement C, Popp MP, Bloom DC, Schultz G, Liu L, Neumann DM, Bhattacharjee PS, Hill JM. Microarray analysis of host gene expression for comparison between naïve and HSV-1 latent rabbit trigeminal ganglia. Mol Vis. 2008 Jul 03; 14:1209-21. PMID: 18615202.
      Citations: 11     Fields:    Translation:AnimalsCells
    26. Toma HS, Murina AT, Areaux RG, Neumann DM, Bhattacharjee PS, Foster TP, Kaufman HE, Hill JM. Ocular HSV-1 latency, reactivation and recurrent disease. Semin Ophthalmol. 2008 Jul-Aug; 23(4):249-73. PMID: 18584563.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    27. Hill JM, Ball MJ, Neumann DM, Azcuy AM, Bhattacharjee PS, Bouhanik S, Clement C, Lukiw WJ, Foster TP, Kumar M, Kaufman HE, Thompson HW. The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender. J Virol. 2008 Aug; 82(16):8230-4. PMID: 18550674.
      Citations: 35     Fields:    Translation:HumansCells
    28. Bhattacharjee PS, Neumann DM, Foster TP, Clement C, Singh G, Thompson HW, Kaufman HE, Hill JM. Effective treatment of ocular HSK with a human apolipoprotein E mimetic peptide in a mouse eye model. Invest Ophthalmol Vis Sci. 2008 Oct; 49(10):4263-8. PMID: 18515564.
      Citations: 17     Fields:    Translation:AnimalsCells
    29. Bhattacharjee PS, Neumann DM, Foster TP, Bouhanik S, Clement C, Vinay D, Thompson HW, Hill JM. Effect of human apolipoprotein E genotype on the pathogenesis of experimental ocular HSV-1. Exp Eye Res. 2008 Aug; 87(2):122-30. PMID: 18572164.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    30. Giordani NV, Neumann DM, Kwiatkowski DL, Bhattacharjee PS, McAnany PK, Hill JM, Bloom DC. During herpes simplex virus type 1 infection of rabbits, the ability to express the latency-associated transcript increases latent-phase transcription of lytic genes. J Virol. 2008 Jun; 82(12):6056-60. PMID: 18400860.
      Citations: 33     Fields:    Translation:AnimalsCells
    31. Neumann DM, Bhattacharjee PS, Giordani NV, Bloom DC, Hill JM. In vivo changes in the patterns of chromatin structure associated with the latent herpes simplex virus type 1 genome in mouse trigeminal ganglia can be detected at early times after butyrate treatment. J Virol. 2007 Dec; 81(23):13248-53. PMID: 17881451.
      Citations: 49     Fields:    Translation:AnimalsCells
    32. Neumann DM, Bhattacharjee PS, Hill JM. Sodium butyrate: a chemical inducer of in vivo reactivation of herpes simplex virus type 1 in the ocular mouse model. J Virol. 2007 Jun; 81(11):6106-10. PMID: 17360760.
      Citations: 19     Fields:    Translation:AnimalsCells
    33. Hill JM, Bhattacharjee PS, Neumann DM. Apolipoprotein E alleles can contribute to the pathogenesis of numerous clinical conditions including HSV-1 corneal disease. Exp Eye Res. 2007 May; 84(5):801-11. PMID: 17007837.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    34. Bhattacharjee PS, Neumann DM, Stark D, Thompson HW, Hill JM. Apolipoprotein E modulates establishment of HSV-1 latency and survival in a mouse ocular model. Curr Eye Res. 2006 Sep; 31(9):703-8. PMID: 16966142.
      Citations: 4     Fields:    Translation:AnimalsCells
    35. Bhattacharjee PS, Tran RK, Myles ME, Maruyama K, Mallakin A, Bloom DC, Hill JM. Overlapping subdeletions within a 348-bp in the 5' exon of the LAT region that facilitates epinephrine-induced reactivation of HSV-1 in the rabbit ocular model do not further define a functional element. Virology. 2003 Jul 20; 312(1):151-8. PMID: 12890628.
      Citations: 5     Fields:    Translation:AnimalsCells
    36. Anand BS, Hill JM, Dey S, Maruyama K, Bhattacharjee PS, Myles ME, Nashed YE, Mitra AK. In vivo antiviral efficacy of a dipeptide acyclovir prodrug, val-val-acyclovir, against HSV-1 epithelial and stromal keratitis in the rabbit eye model. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2529-34. PMID: 12766053.
      Citations: 14     Fields:    Translation:AnimalsCells
    37. Marquart M, Bhattacharjee P, Zheng X, Kaufman H, Thompson H, Varnell E, Hill J. Ocular reactivation phenotype of HSV-1 strain F(MP)E, a corticosteroid-sensitive strain. Curr Eye Res. 2003 Mar-Apr; 26(3-4):205-9. PMID: 12815548.
      Citations: 8     Fields:    Translation:AnimalsCells
    38. Hill J, Patel A, Bhattacharjee P, Krause P. An HSV-1 chimeric containing HSV-2 latency associated transcript (LAT) sequences has significantly reduced adrenergic reactivation in the rabbit eye model. Curr Eye Res. 2003 Mar-Apr; 26(3-4):219-24. PMID: 12815550.
      Citations: 7     Fields:    Translation:AnimalsCells
    39. Miller C, Bhattacharjee P, Higaki S, Jacob R, Danaher R, Thompson H, Hill J. Herpesvirus quiescence (QIF) in neuronal cells VI: Correlative analysis demonstrates usefulness of QIF-PC12 cells to examine HSV-1 latency, reactivation and genes implicated in its regulation. Curr Eye Res. 2003 Mar-Apr; 26(3-4):239-48. PMID: 12815553.
      Citations: 2     Fields:    Translation:AnimalsCells
    40. Chowdhury SI, Onderci M, Bhattacharjee PS, Al-Mubarak A, Weiss ML, Zhou Y. Bovine herpesvirus 5 (BHV-5) Us9 is essential for BHV-5 neuropathogenesis. J Virol. 2002 Apr; 76(8):3839-51. PMID: 11907224.
      Citations: 20     Fields:    Translation:AnimalsCells
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