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Hector Biliran

TitleFaculty, Department of Biology
Faculty RankAssociate Professor
InstitutionXavier University of Louisiana
DepartmentBiology
AddressXavier University of Louisiana
1 Drexel Drive
Biology
New Orleans LA 70125
Phone5045207622
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    Collapse Research 
    Collapse research activities and funding
    SC2CA153382     (BILIRAN, HECTOR RAMOS)May 1, 2010 - Apr 30, 2013
    NIH
    Regulation of anoikis and transformation in human breast cancer cells by Bit1
    Role: Principal Investigator
    R15CA158677     (BILIRAN, HECTOR RAMOS)Feb 28, 2012 - Jul 31, 2019
    NIH
    Bit1 as a tumor suppressor and a therapeutic target in NSCLC
    Role: Principal Investigator
    R16GM145484     (BILIRAN, HECTOR RAMOS)Jun 1, 2022 - Apr 30, 2026
    NIH
    Role of the transcriptional corepressor TLE1 in the lung adenocarcinoma aggressiveness and progression
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dela Cruz MC, Yao X, Roberts N, Iheukwumere P, Carmouche A, Medina PM, Biliran H. TLE1 drives EGFR-TKI resistance in EGFR-mutant lung adenocarcinoma through epithelial to mesenchymal transition. Biochem Biophys Res Commun. 2025 Aug 15; 775:152146. PMID: 40482589.
      Citations:    Fields:    Translation:HumansCells
    2. Haye-Bertolozzi JE, DeFreece CB, Bolden C, Daveron K, Biliran H. Creating A Course Based Undergraduate Research Experience (CURE) Genetics Yeast Laboratory Course at Xavier University of Louisiana. Biochem Mol Biol Educ. 2025 Sep-Oct; 53(5):478-488. PMID: 40407264.
      Citations: 1     Fields:    Translation:HumansAnimals
    3. Yao X, Roberts N, Iheukwumere P, Carmouche A, Chen R, Dela Cruz MC, Biliran H. TLE1 corepressor promotes gefitinib resistance in lung cancer A549 cells via E-cadherin silencing. Biomed Rep. 2025 Mar; 22(3):36. PMID: 39781042.
      Citations:    
    4. Yao X, Gray S, Pham T, Delgardo M, Nguyen A, Do S, Ireland SK, Chen R, Abdel-Mageed AB, Biliran H. Downregulation of Bit1 expression promotes growth, anoikis resistance, and transformation of immortalized human bronchial epithelial cells via Erk activation-dependent suppression of E-cadherin. Biochem Biophys Res Commun. 2018 01 01; 495(1):1240-1248. PMID: 29170133.
      Citations: 10     Fields:    Translation:HumansCells
    5. Yao X, Pham T, Temple B, Gray S, Cannon C, Hardy C, Fletcher K, Ireland SK, Hossain A, Chen R, Abdel-Mageed AB, Biliran H. TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression. Oncotarget. 2017 Sep 22; 8(42):72235-72249. PMID: 29069783.
      Citations: 13     Fields:    
    6. Yao X, Pham T, Temple B, Gray S, Cannon C, Chen R, Abdel-Mageed AB, Biliran H. The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells. PLoS One. 2016; 11(9):e0163228. PMID: 27655370.
      Citations: 14     Fields:    Translation:HumansCells
    7. Yao X, Ireland SK, Pham T, Temple B, Chen R, Raj MH, Biliran H. TLE1 promotes EMT in A549 lung cancer cells through suppression of E-cadherin. Biochem Biophys Res Commun. 2014 Dec 12; 455(3-4):277-84. PMID: 25446087.
      Citations: 29     Fields:    Translation:HumansCells
    8. Yao X, Jennings S, Ireland SK, Pham T, Temple B, Davis M, Chen R, Davenport I, Biliran H. The anoikis effector Bit1 displays tumor suppressive function in lung cancer cells. PLoS One. 2014; 9(7):e101564. PMID: 25003198.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    9. Jenning S, Pham T, Ireland SK, Ruoslahti E, Biliran H. Bit1 in anoikis resistance and tumor metastasis. Cancer Lett. 2013 Jun 10; 333(2):147-51. PMID: 23376255.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    10. Brunquell C, Biliran H, Jennings S, Ireland SK, Chen R, Ruoslahti E. TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells. Mol Cancer Res. 2012 Nov; 10(11):1482-95. PMID: 22952044.
      Citations: 27     Fields:    Translation:HumansCells
    11. Karmali PP, Brunquell C, Tram H, Ireland SK, Ruoslahti E, Biliran H. Metastasis of tumor cells is enhanced by downregulation of Bit1. PLoS One. 2011; 6(8):e23840. PMID: 21886829.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    12. Biliran H, Jan Y, Chen R, Pasquale EB, Ruoslahti E. Protein kinase D is a positive regulator of Bit1 apoptotic function. J Biol Chem. 2008 Oct 17; 283(42):28029-37. PMID: 18703509.
      Citations: 21     Fields:    Translation:HumansCells
    13. Thakur A, Sun Y, Bollig A, Wu J, Biliran H, Banerjee S, Sarkar FH, Liao DJ. Anti-invasive and antimetastatic activities of ribosomal protein S6 kinase 4 in breast cancer cells. Clin Cancer Res. 2008 Jul 15; 14(14):4427-36. PMID: 18628456.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    14. Kairouz-Wahbe R, Biliran H, Luo X, Khor I, Wankell M, Besch-Williford C, Pascual J, Oshima R, Ruoslahti E. Anoikis effector Bit1 negatively regulates Erk activity. Proc Natl Acad Sci U S A. 2008 Feb 05; 105(5):1528-32. PMID: 18218778.
      Citations: 24     Fields:    Translation:AnimalsCells
    15. Liao DJ, Thakur A, Wu J, Biliran H, Sarkar FH. Perspectives on c-Myc, Cyclin D1, and their interaction in cancer formation, progression, and response to chemotherapy. Crit Rev Oncog. 2007 Nov; 13(2):93-158. PMID: 18197790.
      Citations: 64     Fields:    Translation:Humans
    16. Biliran H, Banerjee S, Thakur A, Sarkar FH, Bollig A, Ahmed F, Wu J, Sun Y, Liao JD. c-Myc-induced chemosensitization is mediated by suppression of cyclin D1 expression and nuclear factor-kappa B activity in pancreatic cancer cells. Clin Cancer Res. 2007 May 01; 13(9):2811-21. PMID: 17473215.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    17. Wang Y, Thakur A, Sun Y, Wu J, Biliran H, Bollig A, Liao DJ. Synergistic effect of cyclin D1 and c-Myc leads to more aggressive and invasive mammary tumors in severe combined immunodeficient mice. Cancer Res. 2007 Apr 15; 67(8):3698-707. PMID: 17440082.
      Citations: 19     Fields:    Translation:AnimalsCells
    18. Thakur A, Rahman KW, Wu J, Bollig A, Biliran H, Lin X, Nassar H, Grignon DJ, Sarkar FH, Liao JD. Aberrant expression of X-linked genes RbAp46, Rsk4, and Cldn2 in breast cancer. Mol Cancer Res. 2007 Feb; 5(2):171-81. PMID: 17314274.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    19. Yin S, Lockett J, Meng Y, Biliran H, Blouse GE, Li X, Reddy N, Zhao Z, Lin X, Anagli J, Cher ML, Sheng S. Maspin retards cell detachment via a novel interaction with the urokinase-type plasminogen activator/urokinase-type plasminogen activator receptor system. Cancer Res. 2006 Apr 15; 66(8):4173-81. PMID: 16618739.
      Citations: 32     Fields:    Translation:HumansCells
    20. Thakur A, Xu H, Wang Y, Bollig A, Biliran H, Liao JD. The role of X-linked genes in breast cancer. Breast Cancer Res Treat. 2005 Sep; 93(2):135-43. PMID: 16187233.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    21. Biliran H, Wang Y, Banerjee S, Xu H, Heng H, Thakur A, Bollig A, Sarkar FH, Liao JD. Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line. Clin Cancer Res. 2005 Aug 15; 11(16):6075-86. PMID: 16115953.
      Citations: 93     Fields:    Translation:AnimalsCells
    22. Laakkonen P, Akerman ME, Biliran H, Yang M, Ferrer F, Karpanen T, Hoffman RM, Ruoslahti E. Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9381-6. PMID: 15197262.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    23. Cher ML, Biliran HR, Bhagat S, Meng Y, Che M, Lockett J, Abrams J, Fridman R, Zachareas M, Sheng S. Maspin expression inhibits osteolysis, tumor growth, and angiogenesis in a model of prostate cancer bone metastasis. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7847-52. PMID: 12788977.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    24. Biliran H, Sheng S. Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. Cancer Res. 2001 Dec 15; 61(24):8676-82. PMID: 11751384.
      Citations: 43     Fields:    Translation:HumansCells
    25. McGowen R, Biliran H, Sager R, Sheng S. The surface of prostate carcinoma DU145 cells mediates the inhibition of urokinase-type plasminogen activator by maspin. Cancer Res. 2000 Sep 01; 60(17):4771-8. PMID: 10987285.
      Citations: 31     Fields:    Translation:HumansCells
    26. Elkhaimi M, Kaadige MR, Kamath D, Jackson JC, Biliran H, Lopes JM. Combinatorial regulation of phospholipid biosynthetic gene expression by the UME6, SIN3 and RPD3 genes. Nucleic Acids Res. 2000 Aug 15; 28(16):3160-7. PMID: 10931932.
      Citations: 15     Fields:    Translation:AnimalsCells
    27. Kim HR, Lin HM, Biliran H, Raz A. Cell cycle arrest and inhibition of anoikis by galectin-3 in human breast epithelial cells. Cancer Res. 1999 Aug 15; 59(16):4148-54. PMID: 10463621.
      Citations: 92     Fields:    Translation:HumansCells
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