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Clivel Charlton

TitlePhD
Faculty RankChair and Professor
InstitutionMeharry Medical College
DepartmentBiochem, Cancer Biology, Neuroscience & Pharmacology
Address1005 Dr. D. B. Todd Blvd
Nashville TN 37208
Phone6153276971
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    Collapse Research 
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    R01NS028432     (CHARLTON, CLIVEL GEORGE)May 1, 1992 - May 31, 2004
    NIH
    EXCESS METHYLATION &PARKINSONS DISEASE--PROPOSALS
    Role: Principal Investigator
    R01NS031177     (CHARLTON, CLIVEL GEORGE)Jan 1, 1993 - Dec 31, 1997
    NIH
    PARKINSONISM--A METHYL-DONOR ACTION FOR MPP+
    Role: Principal Investigator
    U54NS041071     (RUCKER, HUBERT K.)Sep 30, 2000 - Aug 31, 2011
    NIH
    SNRP Project at Meharry Medical College
    Role: Co-Principal Investigator
    U01NS041071     (CHARLTON, CLIVEL GEORGE)Sep 30, 2000 - Aug 31, 2013
    NIH
    SNRP Project at Meharry Medical College
    Role: Principal Investigator
    R21NS049623     (CHARLTON, CLIVEL GEORGE)Mar 3, 2006 - Feb 28, 2010
    NIH
    FETAL AND ENVIRONMENTAL BASIS OF PARKINSON'S DISEASE
    Role: Principal Investigator
    R01NS041674     (CHARLTON, CLIVEL GEORGE)Mar 3, 2006 - Feb 28, 2011
    NIH
    L-DOPA OVERLOAD: MECHANISMS FOR THE SIDE EFFECTS.
    Role: Principal Investigator
    R24DA036420     (CHARLTON, CLIVEL G.)Apr 15, 2014 - Dec 31, 2020
    NIH
    Methamphetamine Research Program at Meharry Medical College
    Role: Principal Investigator
    R21ES027663     (CHARLTON, CLIVEL G.)Sep 15, 2018 - Aug 31, 2021
    NIH
    Modeling ALS-PDC: Aligning BMAA toxicity with the birth of neurons involved in ALS-PDC and with aging
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Charlton CG. Methylation reactions at dopaminergic nerve endings, serving as biological off-switches in managing dopaminergic functions. Neural Regen Res. 2014 Jun 01; 9(11):1110-1. PMID: 25206768.
      Citations:    
    2. Smith ML, King J, Dent L, Mackey V, Muthian G, Griffin B, Charlton CG. Effects of acute and sub-chronic L-dopa therapy on striatal L-dopa methylation and dopamine oxidation in an MPTP mouse model of Parkinsons disease. Life Sci. 2014 Aug 06; 110(1):1-7. PMID: 24880075.
      Citations: 6     Fields:    Translation:AnimalsCells
    3. Mackey VR, Muthian G, Smith M, King J, Charlton CG. Prenatal exposure to methanol as a dopamine system sensitization model in C57BL/6J mice. Life Sci. 2012 Nov 02; 91(19-20):921-7. PMID: 23000099.
      Citations: 1     Fields:    Translation:Animals
    4. King JM, Muthian G, Mackey V, Smith M, Charlton C. L-Dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine and its metabolites in an MPTP mouse model of Parkinson's disease. Life Sci. 2011 Oct 24; 89(17-18):638-43. PMID: 21871902.
      Citations: 7     Fields:    Translation:Animals
    5. Muthian G, Mackey V, King J, Charlton CG. Modeling a sensitization stage and a precipitation stage for Parkinson's disease using prenatal and postnatal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Neuroscience. 2010 Sep 01; 169(3):1085-93. PMID: 20540993.
      Citations: 4     Fields:    Translation:Animals
    6. Lee ES, Chen H, Hardman C, Simm A, Charlton C. Excessive S-adenosyl-L-methionine-dependent methylation increases levels of methanol, formaldehyde and formic acid in rat brain striatal homogenates: possible role in S-adenosyl-L-methionine-induced Parkinson's disease-like disorders. Life Sci. 2008 Dec 19; 83(25-26):821-7. PMID: 18930743.
      Citations: 13     Fields:    Translation:AnimalsCells
    7. Lee ES, Chen H, King J, Charlton C. The role of 3-O-methyldopa in the side effects of L-dopa. Neurochem Res. 2008 Mar; 33(3):401-11. PMID: 17713853.
      Citations: 18     Fields:    Translation:AnimalsCells
    8. Shepherd KR, Lee ES, Schmued L, Jiao Y, Ali SF, Oriaku ET, Lamango NS, Soliman KF, Charlton CG. The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on paraquat-induced neurochemical and behavioral changes in mice. Pharmacol Biochem Behav. 2006 Mar; 83(3):349-59. PMID: 16580056.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    9. Lee ES, Chen H, Charlton CG, Soliman KF. The role of phospholipid methylation in 1-methyl-4-phenyl-pyridinium ion (MPP+)-induced neurotoxicity in PC12 cells. Neurotoxicology. 2005 Dec; 26(6):945-57. PMID: 15950286.
      Citations: 5     Fields:    Translation:AnimalsCells
    10. Lee ES, Chen H, Soliman KF, Charlton CG. Effects of homocysteine on the dopaminergic system and behavior in rodents. Neurotoxicology. 2005 Jun; 26(3):361-71. PMID: 15935208.
      Citations: 30     Fields:    Translation:AnimalsCells
    11. Lee ES, Soliman KF, Charlton CG. Lysophosphatidylcholine decreases locomotor activities and dopamine turnover rate in rats. Neurotoxicology. 2005 Jan; 26(1):27-38. PMID: 15527871.
      Citations: 7     Fields:    Translation:Animals
    12. Kim JS, Coon SL, Blackshaw S, Cepko CL, M?ller M, Mukda S, Zhao WQ, Charlton CG, Klein DC. Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. J Biol Chem. 2005 Jan 07; 280(1):677-84. PMID: 15504733.
      Citations: 13     Fields:    Translation:Animals
    13. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. Inhibitory effects of lysophosphatidylcholine on the dopaminergic system. Neurochem Res. 2004 Jul; 29(7):1333-42. PMID: 15202762.
      Citations: 4     Fields:    Translation:AnimalsCells
    14. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter. Neurosci Res. 2004 Mar; 48(3):335-44. PMID: 15154679.
      Citations: 7     Fields:    Translation:AnimalsCells
    15. Lamango NS, Ayuk-Takem LT, Nesby R, Zhao WQ, Charlton CG. Inhibition mechanism of S-adenosylmethionine-induced movement deficits by prenylcysteine analogs. Pharmacol Biochem Behav. 2003 Dec; 76(3-4):433-42. PMID: 14643842.
      Citations: 6     Fields:    Translation:AnimalsCells
    16. Zhao WQ, Williams Z, Shepherd KR, Reuben JS, Lee ES, Darling-Reed S, Lamango N, Soliman KF, Charlton CG. S-adenosyl-methionine-induced apoptosis in PC12 cells. J Neurosci Res. 2002 Aug 15; 69(4):519-29. PMID: 12210845.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Charlton CG, Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol. 1994 Aug-Dec; 9(1-3):149-61. PMID: 7888091.
      Citations: 7     Fields:    Translation:AnimalsCells
    18. Crowell BG, Benson R, Shockley D, Charlton CG. S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson's disease-like symptoms. Behav Neural Biol. 1993 May; 59(3):186-93. PMID: 8503824.
      Citations: 6     Fields:    Translation:Animals
    19. Benson R, Crowell B, Hill B, Doonquah K, Charlton C. The effects of L-dopa on the activity of methionine adenosyltransferase: relevance to L-dopa therapy and tolerance. Neurochem Res. 1993 Mar; 18(3):325-30. PMID: 8479601.
      Citations: 6     Fields:    Translation:Animals
    20. Charlton CG, Crowell B. Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav. 1992 Oct; 43(2):423-31. PMID: 1359575.
      Citations: 4     Fields:    Translation:Animals
    21. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992 Apr-Jun; 5(2):114-8. PMID: 1590912.
      Citations:    Fields:    Translation:Animals
    22. Charlton CG, Crowell B, Benson R. Identification of motor neurons for accessory muscles of inspiration and expiration, pectoralis, trapezius and external oblique: comparison with non-respiratory skeletal muscle. Synapse. 1988; 2(3):219-24. PMID: 3212669.
      Citations:    Fields:    Translation:AnimalsCells
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