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Michael D. Powell

TitleProgram Director
Faculty RankProfessor
InstitutionMorehouse School of Medicine
DepartmentMicrobiology, Biochemistry, & Immunology
Address720 Westveiw Drive, SW
Research Wing Building
Atlanta GA 30310
Phone4047521582
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    My research centers around the HIV-1 protein Nef. Our research has shown that Nef protein is secreted by HIV-1 infected cells and is present in the plasma of infected individuals. Our studies suggest that Nef is secreted from cells in the form of exosomes, small membrane bound vesicles approximately 50-100nm in size. T cells that come in contact with Nef exosomes undego apoptosis. Macrophage can take up Nef exosomes, but their affect on these cells is largely unknown. Nef exosomes appear to play a significant role in the pathogenic effects of HIV-1 infection leading to AIDS. Most recently we have worked with Bruce Shiramizu at the U of Hawaii to investigate the potential of Nef exosomes to facilitate the pathogenesis of HIV Associated Neurologic Disorders (HAND).

    We have also been working with a traditional medicine group called ProMetra. Extracts of natural plants are used to treat HIV/AIDS patients. We have shown that these natural products have the ability to block entry of HIV into T cells. We are interested testing these herbal treatments in a clinical trial. We have recently worked with USAMRIID to also investigate the potential of these herbal treatments to inhibit Ebola virus.

    In another collaboration we are working with Carol Carter at SUNY Stonybrook to investigate host proteins involved in trafficking of Gag protein in HIV-1. Our most recent work has been investigating the host protein "Sprouty" in viral traffiicking,

    I am also the director of our local Proteomics facility we perform LC/MS protein identification and Luminex multiplex protein anaysis.. I would be happy to discuss potential projects with anyone looking for a collaborator.
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Duong HA, Baba K, DeBruyne JP, Davidson AJ, Ehlen C, Powell M, Tosini G. Environmental circadian disruption re-programs liver circadian gene expression. bioRxiv. 2023 Aug 29. PMID: 37693605.
      Citations:    
    2. Khan M, Diop A, Gbodossou E, Xiao P, Coleman M, De Barros K, Duong H, Bond VC, Floyd V, Kondwani K, Rice VM, Harris-Hooker S, Villinger F, Powell MD. Anti-human immunodeficiency virus-1 activity of MoMo30 protein isolated from the traditional African medicinal plant Momordica balsamina. Virol J. 2023 03 22; 20(1):50. PMID: 36949470.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Coleman MI, Khan M, Gbodossou E, Diop A, DeBarros K, Duong H, Bond VC, Floyd V, Kondwani K, Montgomery Rice V, Villinger F, Powell MD. Identification of a Novel Anti-HIV-1 Protein from Momordica balsamina Leaf Extract. Int J Environ Res Public Health. 2022 11 18; 19(22). PMID: 36429944.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Anyanwu SI, Doherty A, Powell MD, Obialo C, Huang MB, Quarshie A, Mitchell C, Bashir K, Newman GW. Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients. Adv Virol. 2018; 2018:7863412. PMID: 29721020.
      Citations:    
    5. Powell MP, Narimova GJ, Halimova ZJ. The Results of Surgical Treatment of Cushing Tumors in the Republic of Uzbekistan: Establishing Transsphenoidal Surgery in A Developing Nation. World Neurosurg. 2017 Jan; 97:213-220. PMID: 27671882.
      Citations: 2     Fields:    Translation:Humans
    6. Konadu KA, Huang MB, Roth W, Armstrong W, Powell M, Villinger F, Bond V. Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals. J Vis Exp. 2016 Jan 05; (107). PMID: 26780239.
      Citations: 36     Fields:    Translation:HumansCells
    7. Huang MB, Ye L, Liang BY, Ning CY, Roth WW, Jiang JJ, Huang JG, Zhou B, Zang N, Powell MD, Liang H, Bond VC. Characterizing the HIV/AIDS Epidemic in the United States and China. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010030. PMID: 26703667.
      Citations: 36     Fields:    Translation:Humans
    8. Roth WW, Huang MB, Addae Konadu K, Powell MD, Bond VC. Micro RNA in Exosomes from HIV-Infected Macrophages. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010032. PMID: 26703692.
      Citations: 30     Fields:    Translation:HumansCells
    9. Khan MB, Lang MJ, Huang MB, Raymond A, Bond VC, Shiramizu B, Powell MD. Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce A?(1-42) secretion in SH-SY5Y neural cells. J Neurovirol. 2016 Apr; 22(2):179-90. PMID: 26407718.
      Citations: 51     Fields:    Translation:HumansCells
    10. Konadu KA, Anderson JS, Huang MB, Ali SA, Powell MD, Villinger F, Bond VC. Hallmarks of HIV-1 pathogenesis are modulated by Nef's Secretion Modification Region. J AIDS Clin Res. 2015 Jul; 6(7). PMID: 26523240.
      Citations:    
    11. Konadu KA, Chu J, Huang MB, Amancha PK, Armstrong W, Powell MD, Villinger F, Bond VC. Association of Cytokines With Exosomes in the Plasma of HIV-1-Seropositive Individuals. J Infect Dis. 2015 Jun 01; 211(11):1712-6. PMID: 25512626.
      Citations: 62     Fields:    Translation:HumansCells
    12. Singh A, Powell MD, Sridaran R, Krishna A. Effects of seasonal adiposity on ovarian activity of Vespertilionid bat, Scotophilus heathi: proteomics analysis. Mol Cell Endocrinol. 2015 Jan 05; 399:219-27. PMID: 25305638.
      Citations:    Fields:    Translation:Animals
    13. Shelton MN, Huang MB, Ali S, Johnson K, Roth W, Powell M, Bond V. Peptide-based identification of functional motifs and their binding partners. J Vis Exp. 2013 Jun 30; (76). PMID: 23852082.
      Citations: 2     Fields:    Translation:HumansCells
    14. Campbell PE, Isayev O, Ali SA, Roth WW, Huang MB, Powell MD, Leszczynski J, Bond VC. Validation of a novel secretion modification region (SMR) of HIV-1 Nef using cohort sequence analysis and molecular modeling. J Mol Model. 2012 Oct; 18(10):4603-13. PMID: 22643973.
      Citations: 7     Fields:    Translation:Cells
    15. Omole FS, Lin JS, Chu T, Sow CM, Flood A, Powell MD. Raynaud's phenomenon, cytokines and acupuncture: a case report. Acupunct Med. 2012 Jun; 30(2):139-41. PMID: 22516031.
      Citations: 4     Fields:    Translation:Humans
    16. Shelton MN, Huang MB, Ali SA, Powell MD, Bond VC. Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release. J Virol. 2012 Jan; 86(1):406-19. PMID: 22013042.
      Citations: 49     Fields:    Translation:HumansCells
    17. Ali SA, Huang MB, Campbell PE, Roth WW, Campbell T, Khan M, Newman G, Villinger F, Powell MD, Bond VC. Genetic characterization of HIV type 1 Nef-induced vesicle secretion. AIDS Res Hum Retroviruses. 2010 Feb; 26(2):173-92. PMID: 20156100.
      Citations: 67     Fields:    Translation:HumansCells
    18. Powell MD, Manandhar G, Spate L, Sutovsky M, Zimmerman S, Sachdev SC, Hannink M, Prather RS, Sutovsky P. Discovery of putative oocyte quality markers by comparative ExacTag proteomics. Proteomics Clin Appl. 2010 Mar; 4(3):337-51. PMID: 21137054.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    19. Harrington W, Bond V, Huang MB, Powell M, Lillard J, Manne U, Bumpers H. HIV Nef-M1 Effects on Colorectal Cancer Growth in Tumor-induced Spleens and Hepatic Metastasis. Mol Cell Pharmacol. 2009 Aug 05; 1(2):85-91. PMID: 20383296.
      Citations:    
    20. Wilson NO, Huang MB, Anderson W, Bond V, Powell M, Thompson WE, Armah HB, Adjei AA, Gyasi R, Tettey Y, Stiles JK. Soluble factors from Plasmodium falciparum-infected erythrocytes induce apoptosis in human brain vascular endothelial and neuroglia cells. Mol Biochem Parasitol. 2008 Dec; 162(2):172-6. PMID: 18848585.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    21. Wang F, Xia P, Wu F, Wang D, Wang W, Ward T, Liu Y, Aikhionbare F, Guo Z, Powell M, Liu B, Bi F, Shaw A, Zhu Z, Elmoselhi A, Fan D, Cover TL, Ding X, Yao X. Helicobacter pylori VacA disrupts apical membrane-cytoskeletal interactions in gastric parietal cells. J Biol Chem. 2008 Sep 26; 283(39):26714-25. PMID: 18625712.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    22. Campbell TD, Khan M, Huang MB, Bond VC, Powell MD. HIV-1 Nef protein is secreted into vesicles that can fuse with target cells and virions. Ethn Dis. 2008; 18(2 Suppl 2):S2-14-9. PMID: 18646314.
      Citations: 69     Fields:    Translation:HumansCells
    23. Huang MB, James CO, Powell MD, Bond VC. Apoptotic peptides derived from HIV-1 Nef induce lymphocyte depletion in mice. Ethn Dis. 2008; 18(2 Suppl 2):S2-30-7. PMID: 18646317.
      Citations: 4     Fields:    Translation:AnimalsCells
    24. Armah HB, Wilson NO, Sarfo BY, Powell MD, Bond VC, Anderson W, Adjei AA, Gyasi RK, Tettey Y, Wiredu EK, Tongren JE, Udhayakumar V, Stiles JK. Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. Malar J. 2007 Nov 12; 6:147. PMID: 17997848.
      Citations: 117     Fields:    Translation:Humans
    25. Thomas K, Wu J, Sung DY, Thompson W, Powell M, McCarrey J, Gibbs R, Walker W. SP1 transcription factors in male germ cell development and differentiation. Mol Cell Endocrinol. 2007 May 30; 270(1-2):1-7. PMID: 17462816.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    26. Miles LR, Agresta BE, Khan MB, Tang S, Levin JG, Powell MD. Effect of polypurine tract (PPT) mutations on human immunodeficiency virus type 1 replication: a virus with a completely randomized PPT retains low infectivity. J Virol. 2005 Jun; 79(11):6859-67. PMID: 15890925.
      Citations: 17     Fields:    Translation:HumansCells
    27. Khan M, Jin L, Miles L, Bond VC, Powell MD. Chimeric human immunodeficiency virus type 1 virions that contain the simian immunodeficiency virus nef gene are cyclosporin A resistant. J Virol. 2005 Mar; 79(5):3211-6. PMID: 15709044.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    28. Bumpers HL, Huang MB, Powell M, Grizzle WE, Lillard JW, Okoli J, Bond VC. Effects of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancer. Cancer Biol Ther. 2005 Jan; 4(1):65-9. PMID: 15662115.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    29. Huang MB, Jin LL, James CO, Khan M, Powell MD, Bond VC. Characterization of Nef-CXCR4 interactions important for apoptosis induction. J Virol. 2004 Oct; 78(20):11084-96. PMID: 15452229.
      Citations: 25     Fields:    Translation:HumansCells
    30. James CO, Huang MB, Khan M, Garcia-Barrio M, Powell MD, Bond VC. Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors. J Virol. 2004 Mar; 78(6):3099-109. PMID: 14990729.
      Citations: 56     Fields:    Translation:HumansCells
    31. Stiles JK, Whittaker J, Sarfo BY, Thompson WE, Powell MD, Bond VC. Trypanosome apoptotic factor mediates apoptosis in human brain vascular endothelial cells. Mol Biochem Parasitol. 2004 Feb; 133(2):229-40. PMID: 14698435.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    32. Khan M, Jin L, Huang MB, Miles L, Bond VC, Powell MD. Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment. J Virol. 2004 Feb; 78(4):1843-50. PMID: 14747548.
      Citations: 5     Fields:    Translation:HumansCells
    33. Khan M, Garcia-Barrio M, Powell MD. Treatment of human immunodeficiency virus type 1 virions depleted of cyclophilin A by natural endogenous reverse transcription restores infectivity. J Virol. 2003 Apr; 77(7):4431-4. PMID: 12634401.
      Citations: 7     Fields:    Translation:HumansCells
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