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Clyde Phelix

InstitutionUniversity of Texas at San Antonio
AddressDepartment of Biology
One UTSA Circle
University of Texas at San Antonio
San Antonio TX 78249
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    Dr. Phelix’s research focus is on integration of systems biology, biomarkers, biosimulations, and modelling in streamlining drug development and biological discoveries. Focus is on intellectual property and commercialization of technologies. Methods apply to all three domains of living organisms, Archae, Bacteria, and Eukarya.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen LY, Phelix CF. Extracellular gating of glucose transport through GLUT 1. Biochem Biophys Res Commun. 2019 04 09; 511(3):573-578. PMID: 30824189.
      Citations: 1     Fields:    Translation:HumansCells
    2. Wang C, Zhao F, Shen K, Wang W, Siedlak SL, Lee HG, Phelix CF, Perry G, Shen L, Tang B, Yan R, Zhu X. The sterol regulatory element-binding protein 2 is dysregulated by tau alterations in Alzheimer disease. Brain Pathol. 2019 07; 29(4):530-543. PMID: 30515907.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Liang H, Bourdon AK, Chen LY, Phelix CF, Perry G. Gibbs Free-Energy Gradient along the Path of Glucose Transport through Human Glucose Transporter 3. ACS Chem Neurosci. 2018 11 21; 9(11):2815-2823. PMID: 29865792.
      Citations:    Fields:    Translation:HumansCells
    4. Wambo TO, Chen LY, Phelix C, Perry G. Affinity and path of binding xylopyranose unto E. coli xylose permease. Biochem Biophys Res Commun. 2017 12 09; 494(1-2):202-206. PMID: 29032199.
      Citations: 1     Fields:    Translation:Cells
    5. Phelix CF, Bourdon AK, Villareal G, LeBaron RG. Modeling non-clinical and clinical drug tests in Gaucher disease. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:1434-1438. PMID: 28268595.
    6. Moritz RJ, LeBaron RG, Phelix CF, Rupaimoole R, Kim HS, Tsin A, Asmis R. Macrophage TGF-ß1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions. Int J Clin Med. 2016 Jul; 7(7):496-510. PMID: 28149671.
    7. Phelix CF, Feltus FA. Plant stress biomarkers from biosimulations: the Transcriptome-To-Metabolome (TTM) technology - effects of drought stress on rice. Plant Biol (Stuttg). 2015 Jan; 17(1):63-73. PMID: 24985701.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Sandstrom RS, Foret MR, Grow DA, Haugen E, Rhodes CT, Cardona AE, Phelix CF, Wang Y, Berger MS, Lin CH. Epigenetic regulation by chromatin activation mark H3K4me3 in primate progenitor cells within adult neurogenic niche. Sci Rep. 2014 Jun 20; 4:5371. PMID: 24947819.
      Citations: 14     Fields:    Translation:AnimalsCells
    9. Phelix CF, Villareal G, LeBaron RG, Roberson DJ. Biomarkers from biosimulations: Transcriptome-To-Reactome™ Technology for individualized medicine. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:3452-5. PMID: 25570733.
    10. Young NA, Szabó CÁ, Phelix CF, Flaherty DK, Balaram P, Foust-Yeoman KB, Collins CE, Kaas JH. Epileptic baboons have lower numbers of neurons in specific areas of cortex. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19107-12. PMID: 24191031.
      Citations: 9     Fields:    Translation:AnimalsCells
    11. Fujioka H, Phelix CF, Friedland RP, Zhu X, Perry EA, Castellani RJ, Perry G. Apolipoprotein E4 prevents growth of malaria at the intraerythrocyte stage: implications for differences in racial susceptibility to Alzheimer's disease. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):70-8. PMID: 24241262.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    12. Perry G, Phelix CF, Nunomura A, Colom LV, Castellani RJ, Petersen RB, Lee HG, Zhu X. Untangling the vascular web from Alzheimer disease and oxidative stress. Can J Neurol Sci. 2012 Jan; 39(1):4. PMID: 22384486.
      Citations:    Fields:    Translation:Humans
    13. Valdez CM, Phelix CF, Smith MA, Perry G, Santamaria F. Modeling cholesterol metabolism by gene expression profiling in the hippocampus. Mol Biosyst. 2011 Jun; 7(6):1891-901. PMID: 21451815.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    14. Rodriguez JS, Boctor SY, Flores LC, Phelix CF, Martinez JL. Local pretreatment with the cannabinoid CB1 receptor antagonist AM251 attenuates methamphetamine intra-accumbens self-administration. Neurosci Lett. 2011 Feb 11; 489(3):187-91. PMID: 21167256.
      Citations: 4     Fields:    Translation:Animals
    15. Valdez CM, Smith MA, Perry G, Phelix CF, Santamaria F. Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers. Hippocampus. 2010 Aug; 20(8):902-5. PMID: 20054815.
      Citations: 12     Fields:    Translation:AnimalsCells
    16. Qiao M, Zhao Q, Lee CF, Tannock LR, Smart EJ, LeBaron RG, Phelix CF, Rangel Y, Asmis R. Thiol oxidative stress induced by metabolic disorders amplifies macrophage chemotactic responses and accelerates atherogenesis and kidney injury in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1779-86. PMID: 19592463.
      Citations: 26     Fields:    Translation:AnimalsCells
    17. Zamilpa R, Rupaimoole R, Phelix CF, Somaraki-Cormier M, Haskins W, Asmis R, LeBaron RG. C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. Matrix Biol. 2009 Jul; 28(6):347-53. PMID: 19505574.
      Citations: 9     Fields:    Translation:HumansCells
    18. Riojas MA, Villanueva-Vedia RE, Zamilpa R, Chen X, Du LC, Phelix CF, LeBaron RG. Prevalence of diabetes mellitus and correlation of urinary transforming growth factor-beta1 with blood hemoglobin A1C in the Atascosa Diabetes Study. Ethn Dis. 2008; 18(2 Suppl 2):S2-54-9. PMID: 18646321.
      Citations: 1     Fields:    Translation:Humans
    19. Rodriguez JS, Boctor SY, Phelix CF, Martinez JL. Differences in performance between Sprague-Dawley and Fischer 344 rats in positive reinforcement tasks. Pharmacol Biochem Behav. 2008 Mar; 89(1):17-22. PMID: 18068221.
      Citations: 6     Fields:    Translation:AnimalsCells
    20. Valtier S, Phelix CF, Cody JT. Analysis of MDMA and its metabolites in urine and plasma following a neurotoxic dose of MDMA. J Anal Toxicol. 2007 Apr; 31(3):138-43. PMID: 17579960.
      Citations: 5     Fields:    Translation:Animals
    21. Seaman RL, Phelix CF. Acute effects of pulsed microwaves and 3-nitropropionic acid on neuronal ultrastructure in the rat caudate-putamen. Bioelectromagnetics. 2005 Feb; 26(2):82-101. PMID: 15672367.
      Citations:    Fields:    Translation:AnimalsCells
    22. Wayner MJ, Armstrong DL, Phelix CF, Oomura Y. Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo. Peptides. 2004 Jun; 25(6):991-6. PMID: 15203246.
      Citations: 59     Fields:    Translation:Animals
    23. Wayner MJ, Armstrong DL, Phelix CF. Ethanol effects on dentate granule cell LTP. Neurotox Res. 2004; 5(8):599-604. PMID: 15111236.
      Citations: 1     Fields:    Translation:Animals
    24. Polan JL, Morse B, Wetherold S, Villanueva-Vedia RE, Phelix C, Barera-Roderiquiz E, Waggoner D, Goswami N, Munoz O, Agrawal CM, Bailey SR. VEGF analysis induced by endothelialized gas-plasma treated D,L-PLA scaffolds. Cardiovasc Radiat Med. 2002 Jul-Dec; 3(3-4):176-82. PMID: 12974370.
      Citations: 2     Fields:    Translation:HumansAnimals
    25. Bailey SR, Polan JL, Morse B, Wetherold S, Villanueva-Vedia RE, Waggoner D, Phelix C, Barera-Roderiquiz E, Goswami N, Munoz O, Agrawal CM. Angiogenic bFGF expression from gas-plasma treated scaffolds. Cardiovasc Radiat Med. 2002 Jul-Dec; 3(3-4):183-9. PMID: 12974371.
      Citations:    Fields:    Translation:Animals
    26. Li XL, Aou S, Oomura Y, Hori N, Fukunaga K, Hori T. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience. 2002; 113(3):607-15. PMID: 12150780.
      Citations: 166     Fields:    Translation:Animals
    27. Wayner MJ, Armstrong DL, Phelix CF, Wright JW, Harding JW. Angiotensin IV enhances LTP in rat dentate gyrus in vivo. Peptides. 2001 Sep; 22(9):1403-14. PMID: 11514021.
      Citations: 20     Fields:    Translation:AnimalsCells
    28. Wayner MJ, Tracy HA, Armstrong DL, Phelix CF. Air righting: role of the NMDA receptor channel and hippocampal LTP. Physiol Behav. 2000 Jun 1-15; 69(4-5):505-10. PMID: 10913790.
      Citations:    Fields:    Translation:Animals
    29. Phelix CF, Chen H, Trevino G, Lara JR, Liu G, Wayner MJ. Bicuculline sensitive depressor response to ethanol infusion into the lateral hypothalamus. Alcohol. 1999 Oct; 19(2):177-85. PMID: 10548163.
      Citations: 2     Fields:    Translation:Animals
    30. Phelix CF, Adai DM, Cantu C, Chen H, Wayner MJ. Immunohistochemical demonstration of serotonin-containing axons in the hypothalamus of the white-footed mouse, Peromyscus leucopus. Brain Res. 1998 Oct 19; 808(2):197-219. PMID: 9767166.
      Citations: 1     Fields:    Translation:AnimalsCells
    31. Broderick PA, Phelix CF. I. Serotonin (5-HT) within dopamine reward circuits signals open-field behavior. II. Basis for 5-HT--DA interaction in cocaine dysfunctional behavior. Neurosci Biobehav Rev. 1997 May; 21(3):227-60. PMID: 9168262.
      Citations: 12     Fields:    Translation:Animals
    32. Wayner MJ, Phelix CF, Armstrong DL. Lateral hypothalamic stimulation inhibits dentate granule cell LTP: direct connections. Brain Res Bull. 1997; 43(1):5-15. PMID: 9205788.
      Citations: 3     Fields:    Translation:AnimalsCells
    33. Wayner MJ, Chitwood R, Armstrong DL, Phelix C. Ethanol affects hypothalamic neurons projecting to the hippocampus and inhibits dentate granule cell LTP. Alcohol. 1997 Jan-Feb; 14(1):1-7. PMID: 9014017.
      Citations: 2     Fields:    Translation:AnimalsCells
    34. Wayner MJ, Armstrong DL, Phelix CF. Nicotine blocks angiotensin II inhibition of LTP in the dentate gyrus. Peptides. 1996; 17(7):1127-33. PMID: 8959746.
      Citations: 1     Fields:    Translation:Animals
    35. Sadile AG, Cerbone A, Lamberti-D'Mello C, Amoroso S, Annunziato L, Menna T, Buono C, Rafti F, Giuditta A. The dorsal noradrenergic bundle modulates DNA remodeling in the rat brain upon exposure to a spatial novelty. Brain Res Bull. 1995; 37(1):9-16. PMID: 7606484.
      Citations: 1     Fields:    Translation:Animals
    36. Phelix CF, Broderick PA. Light microscopic immunocytochemical evidence of converging serotonin and dopamine terminals in ventrolateral nucleus accumbens. Brain Res Bull. 1995; 37(1):37-40. PMID: 7606477.
      Citations: 7     Fields:    Translation:AnimalsCells
    37. Phelix CF, Liposits Z, Paull WK. Catecholamine-CRF synaptic interaction in a septal bed nucleus: afferents of neurons in the bed nucleus of the stria terminalis. Brain Res Bull. 1994; 33(1):109-19. PMID: 7903902.
      Citations: 25     Fields:    Translation:AnimalsCells
    38. Phelix CF, Liposits Z, Paull WK. Monoamine innervation of bed nucleus of stria terminalis: an electron microscopic investigation. Brain Res Bull. 1992 Jun; 28(6):949-65. PMID: 1379113.
      Citations: 33     Fields:    Translation:AnimalsCells
    39. Phelix CF, Liposits Z, Paull WK. Serotonin-CRF interaction in the bed nucleus of the stria terminalis: a light microscopic double-label immunocytochemical analysis. Brain Res Bull. 1992 Jun; 28(6):943-8. PMID: 1638421.
      Citations: 18     Fields:    Translation:Animals
    40. Phelix CF, Paull WK. Anterograde neuroanatomical tract tracing with central nervous system injections of immunoglobulin G: a light and electron microscopic evaluation. Brain Res Bull. 1991 Aug; 27(2):255-60. PMID: 1742614.
      Citations:    Fields:    Translation:AnimalsCells
    41. Milam SB, Klebe RJ, Triplett RG, Herbert D. Characterization of the extracellular matrix of the primate temporomandibular joint. J Oral Maxillofac Surg. 1991 Apr; 49(4):381-91. PMID: 1706426.
      Citations: 13     Fields:    Translation:Animals
    42. Phelix CF, Hartle DK. Systemic glutamate induces degeneration of a subpopulation of serotonin-immunoreactive neurons in the area postrema of rats. Neurosci Lett. 1990 Sep 04; 117(1-2):31-6. PMID: 2290618.
      Citations:    Fields:    Translation:AnimalsCells
    43. Phelix CF, Hartle DK. Systemic glutamate induces degeneration of a subpopulation of tyrosine hydroxylase-immunoreactive neurons in the rat area postrema. Brain Res. 1990 May 21; 516(2):335-40. PMID: 1973067.
      Citations: 1     Fields:    Translation:Animals
    44. Phelix CF, Krause WJ. Tyrosine hydroxylase- and corticotropin releasing factor-immunoreactivity in the olfactory bulb of the opossum (Didelphis virgianina). Z Mikrosk Anat Forsch. 1990; 104(4):650-6. PMID: 1981820.
      Citations:    Fields:    Translation:Animals
    45. Phelix CF, Paull WK. Demonstration of distinct corticotropin releasing factor--containing neuron populations in the bed nucleus of the stria terminalis. A light and electron microscopic immunocytochemical study in the rat. Histochemistry. 1990; 94(4):345-64. PMID: 2228733.
      Citations: 16     Fields:    Translation:AnimalsCells
    46. Lin PJ, Phelix C, Krause WJ. An immunohistochemical study of olfactory epithelium in the opossum before and after birth. Z Mikrosk Anat Forsch. 1988; 102(2):272-82. PMID: 3414149.
      Citations: 3     Fields:    Translation:Animals
    47. Liposits Z, Phelix C, Paull WK. Synaptic interaction of serotonergic axons and corticotropin releasing factor (CRF) synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A light and electron microscopic immunocytochemical study. Histochemistry. 1987; 86(6):541-9. PMID: 3497137.
      Citations: 28     Fields:    Translation:AnimalsCells
    48. Liposits Z, Sherman D, Phelix C, Paull WK. A combined light and electron microscopic immunocytochemical method for the simultaneous localization of multiple tissue antigens. Tyrosine hydroxylase immunoreactive innervation of corticotropin releasing factor synthesizing neurons in the paraventricular nucleus of the rat. Histochemistry. 1986; 85(2):95-106. PMID: 2875047.
      Citations: 31     Fields:    Translation:Animals
    49. Liposits Z, Phelix C, Paull WK. Adrenergic innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A combined light and electron microscopic immunocytochemical study. Histochemistry. 1986; 84(3):201-5. PMID: 3519543.
      Citations: 31     Fields:    Translation:AnimalsCells
    50. Liposits Z, Phelix C, Paull WK. Electron microscopic analysis of tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine-N-methyltransferase immunoreactive innervation of the hypothalamic paraventricular nucleus in the rat. Histochemistry. 1986; 84(2):105-20. PMID: 2872191.
      Citations: 16     Fields:    Translation:AnimalsCells
    51. Neeley SP, Cross AJ, Crow TJ, Johnson JA, Taylor GR. Herpes simplex virus encephalitis. Neuroanatomical and neurochemical selectivity. J Neurol Sci. 1985 Dec; 71(2-3):325-37. PMID: 3003257.
      Citations: 5     Fields:    Translation:AnimalsCells
    52. Paull WK, Phelix CF, Copeland M, Palmiter P, Gibbs FP, Middleton C. Immunohistochemical localization of corticotropin releasing factor (CRF) in the hypothalamus of the squirrel monkey, Saimiri sciureus. Peptides. 1984; 5 Suppl 1:45-51. PMID: 6384953.
      Citations: 3     Fields:    Translation:AnimalsCells
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