"Cathepsin K" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.
| Descriptor ID |
D056657
|
| MeSH Number(s) |
D08.811.277.656.224.405 D08.811.277.656.262.500.156 D08.811.277.656.300.200.156
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cathepsin K".
Below are MeSH descriptors whose meaning is more specific than "Cathepsin K".
This graph shows the total number of publications written about "Cathepsin K" by people in this website by year, and whether "Cathepsin K" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cathepsin K" by people in Profiles.
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Boskey AL, Gelb BD, Pourmand E, Kudrashov V, Doty SB, Spevak L, Schaffler MB. Ablation of cathepsin k activity in the young mouse causes hypermineralization of long bone and growth plates. Calcif Tissue Int. 2009 Mar; 84(3):229-39.
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Li CY, Jepsen KJ, Majeska RJ, Zhang J, Ni R, Gelb BD, Schaffler MB. Mice lacking cathepsin K maintain bone remodeling but develop bone fragility despite high bone mass. J Bone Miner Res. 2006 Jun; 21(6):865-75.