The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.

Descriptor ID	D016723
MeSH Number(s)	G11.427.213 G16.762.150
Concept/Terms	Bone Remodeling Bone Remodeling Remodeling, Bone Bone Turnover Bone Turnovers Turnover, Bone Turnovers, Bone

Below are MeSH descriptors whose meaning is more general than "Bone Remodeling".

Below are MeSH descriptors whose meaning is related to "Bone Remodeling".

Below are MeSH descriptors whose meaning is more specific than "Bone Remodeling".