"Protein Kinase C-epsilon" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein kinase C subtype that was originally characterized as a CALCIUM-independent, serine-threonine kinase that is activated by PHORBOL ESTERS and DIACYLGLYCEROLS. It is targeted to specific cellular compartments in response to extracellular signals that activate G-PROTEIN-COUPLED RECEPTORS; TYROSINE KINASE RECEPTORS; and intracellular protein tyrosine kinase.
| Descriptor ID |
D051744
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.725.750
|
| Concept/Terms |
Protein Kinase C-epsilon- Protein Kinase C-epsilon
- Kinase C-epsilon, Protein
- PKC-epsilon Serine Threonine Kinase
- PKC epsilon Serine Threonine Kinase
- Protein Kinase C epsilon
- PKC epsilon
|
Below are MeSH descriptors whose meaning is more general than "Protein Kinase C-epsilon".
Below are MeSH descriptors whose meaning is more specific than "Protein Kinase C-epsilon".
This graph shows the total number of publications written about "Protein Kinase C-epsilon" by people in this website by year, and whether "Protein Kinase C-epsilon" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2011 | 0 | 3 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein Kinase C-epsilon" by people in Profiles.
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Zuo G, Zhang T, Huang L, Araujo C, Peng J, Travis Z, Okada T, Ocak U, Zhang G, Tang J, Lu X, Zhang JH. Activation of TGR5 with INT-777 attenuates oxidative stress and neuronal apoptosis via cAMP/PKCe/ALDH2 pathway after subarachnoid hemorrhage in rats. Free Radic Biol Med. 2019 11 01; 143:441-453.
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McBride DW, Reis C, Zhang JH, Applegate R, Tang J. Remote Limb Ischemic Preconditioning Attenuates Cerebrovascular Depression During Sinusoidal Galvanic Vestibular Stimulation via a1-Adrenoceptor-Protein Kinase Ce-Endothelial NO Synthase Pathway in Rats. J Am Heart Assoc. 2018 03 24; 7(7).
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Nu?ez RE, Javadov S, Escobales N. Angiotensin II-preconditioning is associated with increased PKCe/PKCd ratio and prosurvival kinases in mitochondria. Clin Exp Pharmacol Physiol. 2017 Dec; 44(12):1201-1212.
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Huang J, Guo J, Beigi F, Hodgkinson CP, Facundo HT, Zhang Z, Espinoza-Derout J, Zhou X, Pratt RE, Mirotsou M, Dzau VJ. HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. J Mol Cell Cardiol. 2014 Jan; 66:157-64.
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Chen X, Guo Z, Okoro EU, Zhang H, Zhou L, Lin X, Rollins AT, Yang H. Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2. J Biol Chem. 2012 Feb 03; 287(6):3751-9.
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Shankar E, Vykhovanets EV, Vykhovanets OV, Maclennan GT, Singh R, Bhaskaran N, Shukla S, Gupta S. High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-?B. Prostate. 2012 Feb; 72(3):233-43.
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Nasser MW, Marjoram RJ, Brown SL, Richardson RM. Cross-desensitization among CXCR1, CXCR2, and CCR5: role of protein kinase C-epsilon. J Immunol. 2005 Jun 01; 174(11):6927-33.
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Sakwe AM, Rask L, Gylfe E. Protein kinase C modulates agonist-sensitive release of Ca2+ from internal stores in HEK293 cells overexpressing the calcium sensing receptor. J Biol Chem. 2005 Feb 11; 280(6):4436-41.
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Sakwe AM, Larsson M, Rask L. Involvement of protein kinase C-alpha and -epsilon in extracellular Ca(2+) signalling mediated by the calcium sensing receptor. Exp Cell Res. 2004 Jul 15; 297(2):560-73.
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Cao Z, Wang Y, Reid EA, McShepard G, Kemp M, Newkirk RF, Townsel JG. The quantitative distribution of a putative PKC epsilon mRNA in Limulus central nervous system by modified competitive RT-PCR. J Neurosci Methods. 2001 Feb 15; 105(2):193-9.