Chemokine CCL21

"Chemokine CCL21" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.

Descriptor ID	D054421
MeSH Number(s)	D12.644.276.374.200.110.890 D12.776.467.374.200.110.890 D23.125.300.110.890 D23.469.200.110.890 D23.529.374.200.110.890
Concept/Terms	Chemokine CCL21 Chemokine CCL21 CCL21, Chemokine 6Ckine SLC Chemokine Chemokine, SLC Exodus-2 Chemokine Chemokine, Exodus-2 Exodus 2 Chemokine Secondary Lymphoid-Tissue Chemokine Chemokine, Secondary Lymphoid-Tissue Lymphoid-Tissue Chemokine, Secondary Secondary Lymphoid Tissue Chemokine Thymus-Derived Chemotactic Agent 4 Thymus Derived Chemotactic Agent 4 CCL21 Chemokine Chemokine, CCL21

Below are MeSH descriptors whose meaning is more general than "Chemokine CCL21".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Chemokines [D12.644.276.374.200]
Chemokines, CC [D12.644.276.374.200.110]
Chemokine CCL21 [D12.644.276.374.200.110.890]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Chemokines [D12.776.467.374.200]
Chemokines, CC [D12.776.467.374.200.110]
Chemokine CCL21 [D12.776.467.374.200.110.890]
Biological Factors [D23]
Chemotactic Factors [D23.125]
Chemokines [D23.125.300]
Chemokines, CC [D23.125.300.110]
Chemokine CCL21 [D23.125.300.110.890]
Inflammation Mediators [D23.469]
Chemokines [D23.469.200]
Chemokines, CC [D23.469.200.110]
Chemokine CCL21 [D23.469.200.110.890]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Chemokines [D23.529.374.200]
Chemokines, CC [D23.529.374.200.110]
Chemokine CCL21 [D23.529.374.200.110.890]

Below are MeSH descriptors whose meaning is related to "Chemokine CCL21".

Below are MeSH descriptors whose meaning is more specific than "Chemokine CCL21".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Chemokine CCL21" by people in this website by year, and whether "Chemokine CCL21" was a major or minor topic of these publications.

Bar chart showing 9 publications over 6 distinct years, with a maximum of 3 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	1	0	1
2009	1	0	1
2010	2	1	3
2012	0	1	1
2013	0	1	1
2021	1	1	2

Below are the most recent publications written about "Chemokine CCL21" by people in Profiles.

Cardona CI, Rodriguez A, Torres VC, Sanchez A, Torres A, Vazquez AE, Wagler AE, Brissette MA, Bill CA, Vines CM. C-C Chemokine Receptor 7 Promotes T-Cell Acute Lymphoblastic Leukemia Invasion of the Central Nervous System via ?2-Integrins. Int J Mol Sci. 2024 Sep 06; 25(17).

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Feng Y, Zhong X, Ni HF, Wang C, Tang TT, Wang LT, Song KY, Tang RN, Liu H, Liu BC, Lv LL. Urinary small extracellular vesicles derived CCL21 mRNA as biomarker linked with pathogenesis for diabetic nephropathy. J Transl Med. 2021 08 17; 19(1):355.

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Bastow CR, Bunting MD, Kara EE, McKenzie DR, Caon A, Devi S, Tolley L, Mueller SN, Frazer IH, Harvey N, Condina MR, Young C, Hoffmann P, McColl SR, Comerford I. Scavenging of soluble and immobilized CCL21 by ACKR4 regulates peripheral dendritic cell emigration. Proc Natl Acad Sci U S A. 2021 04 27; 118(17).

View in: PubMed
McGovern KE, Nance JP, David CN, Harrison RES, Noor S, Worth D, Landrith TA, Obenaus A, Carson MJ, Morikis D, Wilson EH. SPARC coordinates extracellular matrix remodeling and efficient recruitment to and migration of antigen-specific T cells in the brain following infection. Sci Rep. 2021 02 25; 11(1):4549.

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Carson MJ, Wilson EH. Visualizing chemokine-dependent T cell activation and migration in response to central nervous system infection. Methods Mol Biol. 2013; 1013:171-83.

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Shannon LA, McBurney TM, Wells MA, Roth ME, Calloway PA, Bill CA, Islam S, Vines CM. CCR7/CCL19 controls expression of EDG-1 in T cells. J Biol Chem. 2012 Apr 06; 287(15):11656-64.

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Shannon LA, Calloway PA, Welch TP, Vines CM. CCR7/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1/2 in primary T lymphocytes. J Biol Chem. 2010 Dec 10; 285(50):38781-7.

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Ploix CC, Noor S, Crane J, Masek K, Carter W, Lo DD, Wilson EH, Carson MJ. CNS-derived CCL21 is both sufficient to drive homeostatic CD4+ T cell proliferation and necessary for efficient CD4+ T cell migration into the CNS parenchyma following Toxoplasma gondii infection. Brain Behav Immun. 2011 Jul; 25(5):883-96.

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Noor S, Habashy AS, Nance JP, Clark RT, Nemati K, Carson MJ, Wilson EH. CCR7-dependent immunity during acute Toxoplasma gondii infection. Infect Immun. 2010 May; 78(5):2257-63.

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Ploix C, Zuberi RI, Liu FT, Carson MJ, Lo DD. Induction and effector phase of allergic lung inflammation is independent of CCL21/CCL19 and LT-beta. Int J Med Sci. 2009; 6(2):85-92.

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