MAP Kinase Kinase 4

"MAP Kinase Kinase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.

Descriptor ID	D048670
MeSH Number(s)	D08.811.913.696.620.682.700.565.400 D08.811.913.696.620.682.725.200.400 D12.644.360.440.400 D12.776.476.440.400
Concept/Terms	MAP Kinase Kinase 4 MAP Kinase Kinase 4 JN Kinase Kinase JNK Kinase Jun Amino-Terminal Kinase Kinase Jun Amino Terminal Kinase Kinase JNK-Activating Protein Kinase JNK Activating Protein Kinase Protein Kinase, JNK-Activating SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1 SAP Kinase Extracellular Signal Regulated Kinase Kinase 1 SEK1 Protein Kinase Protein Kinase, SEK1 Mitogen-Activated Protein Kinase Kinase 4 Mitogen Activated Protein Kinase Kinase 4 MEK4 Protein Kinase Protein Kinase, MEK4 JNKK1 Protein Kinase Kinase, JNKK1 Protein Protein Kinase, JNKK1 Stress-Activated Protein Kinase Kinase 1 Stress Activated Protein Kinase Kinase 1 SAPK-ERK Kinase 1 SAPK ERK Kinase 1 SAP Kinase Kinase 1

Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 4".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
MAP Kinase Kinase 4 [D08.811.913.696.620.682.700.565.400]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
MAP Kinase Kinase 4 [D08.811.913.696.620.682.725.200.400]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Mitogen-Activated Protein Kinase Kinases [D12.644.360.440]
MAP Kinase Kinase 4 [D12.644.360.440.400]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Mitogen-Activated Protein Kinase Kinases [D12.776.476.440]
MAP Kinase Kinase 4 [D12.776.476.440.400]

Below are MeSH descriptors whose meaning is related to "MAP Kinase Kinase 4".

Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "MAP Kinase Kinase 4" by people in this website by year, and whether "MAP Kinase Kinase 4" was a major or minor topic of these publications.

Bar chart showing 25 publications over 16 distinct years, with a maximum of 4 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	1	2
1999	0	1	1
2001	0	1	1
2004	0	1	1
2006	2	0	2
2007	0	2	2
2008	1	0	1
2009	0	1	1
2010	0	1	1
2011	0	4	4
2012	0	2	2
2013	1	0	1
2014	1	0	1
2015	0	2	2
2018	0	2	2
2020	1	0	1

Below are the most recent publications written about "MAP Kinase Kinase 4" by people in Profiles.

Chen X, Hao A, Li X, Ye K, Zhao C, Yang H, Ma H, Hu L, Zhao Z, Hu L, Ye F, Sun Q, Zhang H, Wang H, Yao X, Fang Z. Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression. Theranostics. 2020; 10(3):998-1015.

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Chen S, Zhao L, Sherchan P, Ding Y, Yu J, Nowrangi D, Tang J, Xia Y, Zhang JH. Activation of melanocortin receptor 4 with RO27-3225 attenuates neuroinflammation through AMPK/JNK/p38 MAPK pathway after intracerebral hemorrhage in mice. J Neuroinflammation. 2018 Apr 11; 15(1):106.

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Mondal T, Bag I, Sncvl P, Garikapati KR, Bhadra U, Pal Bhadra M. Two way controls of apoptotic regulators consign DmArgonaute-1 a better clasp on it. PLoS One. 2018; 13(1):e0190548.

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Peng B, Chai Y, Li Y, Liu X, Zhang J. CIP2A overexpression induces autoimmune response and enhances JNK signaling pathway in human lung cancer. BMC Cancer. 2015 Nov 11; 15:895.

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Bauer D, Redmon N, Mazzio E, Taka E, Reuben JS, Day A, Sadrud-Din S, Flores-Rozas H, Soliman KF, Darling-Reed S. Diallyl disulfide inhibits TNFa induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling. Cytokine. 2015 Sep; 75(1):117-26.

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Jang S, Javadov S. Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK. PLoS One. 2014; 9(11):e113526.

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Song NR, Lee E, Byun S, Kim JE, Mottamal M, Park JH, Lim SS, Bode AM, Lee HJ, Lee KW, Dong Z. Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Cancer Prev Res (Phila). 2013 Dec; 6(12):1293-303.

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Manaenko A, Sun X, Kim CH, Yan J, Ma Q, Zhang JH. PAR-1 antagonist SCH79797 ameliorates apoptosis following surgical brain injury through inhibition of ASK1-JNK in rats. Neurobiol Dis. 2013 Feb; 50:13-20.

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Piccini A, Borghi R, Guglielmotto M, Tamagno E, Cirmena G, Garuti A, Pollero V, Cammarata S, Fornaro M, Messa M, Colombo L, Salmona M, Perry G, Tabaton M. ?-amyloid 1-42 induces physiological transcriptional regulation of BACE1. J Neurochem. 2012 Sep; 122(5):1023-31.

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Sinha-Hikim I, Sinha-Hikim AP, Shen R, Kim HJ, Kim H, French SW, Vaziri ND, Vaziri ND, Crum AC, Crum A, Rajavashisth TB, Norris KC. A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice. Exp Mol Pathol. 2011 Aug; 91(1):419-28.

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