"Tetrahydroisoquinolines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.
| Descriptor ID |
D044005
|
| MeSH Number(s) |
D03.633.100.531.820
|
| Concept/Terms |
Tetrahydroisoquinolines- Tetrahydroisoquinolines
- Tetrahydro-Isoquinolines
- Tetrahydro Isoquinolines
- 1,2,3,4-Tetrahydroisoquinolines
|
Below are MeSH descriptors whose meaning is more general than "Tetrahydroisoquinolines".
Below are MeSH descriptors whose meaning is more specific than "Tetrahydroisoquinolines".
This graph shows the total number of publications written about "Tetrahydroisoquinolines" by people in this website by year, and whether "Tetrahydroisoquinolines" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 3 | 0 | 3 |
| 2009 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
| 2021 | 2 | 1 | 3 |
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Below are the most recent publications written about "Tetrahydroisoquinolines" by people in Profiles.
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Gangapuram M, Mazzio EA, Redda KK, Soliman KFA. Transcriptome Profile Analysis of Triple-Negative Breast Cancer Cells in Response to a Novel Cytostatic Tetrahydroisoquinoline Compared to Paclitaxel. Int J Mol Sci. 2021 Jul 19; 22(14).
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Cordone P, Namballa HK, Muniz B, Pal RK, Gallicchio E, Harding WW. New tetrahydroisoquinoline-based D3R ligands with an o-xylenyl linker motif. Bioorg Med Chem Lett. 2021 06 15; 42:128047.
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Gangapuram M, Eyunni S, Zhang W, Redda KK. Design and Synthesis of Tetrahydroisoquinoline Derivatives as Anti-Angiogenesis and Anti-Cancer Agents. Anticancer Agents Med Chem. 2021; 21(18):2505-2511.
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Gangapuram M, Jean R, Mazzio E, Badisa R, Eyunni S, Goodman CB, Redda KK, Soliman KF. Substituted Tetrahydroisoquinolines as Microtubule-destabilizing Agents in Triple Negative Human Breast Cancer Cells. Anticancer Res. 2016 10; 36(10):5043-5052.
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Ofori E, Zhu XY, Etukala JR, Bricker BA, Ablordeppey SY. Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors. Bioorg Med Chem. 2016 11 15; 24(22):5730-5740.
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Felicilda-Reynaldo RF. A review of anticholinergic medications for overactive bladder symptoms. Medsurg Nurs. 2013 Mar-Apr; 22(2):119-23.
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Karla PK, Earla R, Boddu SH, Johnston TP, Pal D, Mitra A. Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells. Curr Eye Res. 2009 Jan; 34(1):1-9.
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Song Y, Xu J, Hamme A, Liu YM. Capillary liquid chromatography-tandem mass spectrometry of tetrahydroisoquinoline derived neurotoxins: a study on the blood-brain barrier of rat brain. J Chromatogr A. 2006 Jan 27; 1103(2):229-34.
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Song Y, Feng Y, Leblanc MH, Castagloni N, Liu YM. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline passes through the blood-brain barrier of rat brain: an in vivo microdialysis study. Neurosci Lett. 2006 Feb 27; 395(1):63-6.
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Quan Z, Song Y, Saulsberry A, Sheng Y, Liu YM. Capillary electrophoresis for diastereomers of (R,S)-tetrahydroisoquinoline-3-carboxylic acid derivatized with (R)-4-nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole: effect of molecular geometries. J Chromatogr Sci. 2005 Mar; 43(3):121-5.