DNA Gyrase

"DNA Gyrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.

Descriptor ID	D027081
MeSH Number(s)	D08.811.399.403.741.149 D12.776.097.237
Concept/Terms	DNA Gyrase DNA Gyrase DNA-Gyrase DNA Gyrase B Subunit DNA Gyrase B Subunit GyrB Protein DNA Gyrase A Subunit DNA Gyrase A Subunit GyrA Protein

Below are MeSH descriptors whose meaning is more general than "DNA Gyrase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Isomerases [D08.811.399]
DNA Topoisomerases [D08.811.399.403]
DNA Topoisomerases, Type II [D08.811.399.403.741]
DNA Gyrase [D08.811.399.403.741.149]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Bacterial Proteins [D12.776.097]
DNA Gyrase [D12.776.097.237]

Below are MeSH descriptors whose meaning is more specific than "DNA Gyrase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA Gyrase" by people in this website by year, and whether "DNA Gyrase" was a major or minor topic of these publications.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 2001 and 2004 and 2006 and 2007 and 2011 and 2015 and 2016 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2001	1	0	1
2004	0	1	1
2006	0	1	1
2007	0	1	1
2011	0	1	1
2015	0	1	1
2016	0	1	1
2020	0	1	1

Below are the most recent publications written about "DNA Gyrase" by people in Profiles.

Fern?ndez-Coll L, Maciag-Dorszynska M, Tailor K, Vadia S, Levin PA, Szalewska-Palasz A, Cashel M. The Absence of (p)ppGpp Renders Initiation of Escherichia coli Chromosomal DNA Synthesis Independent of Growth Rates. mBio. 2020 03 10; 11(2).

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Denman S, Plummer S, Kirk S, Peace A, McDonald JE. Isolation studies reveal a shift in the cultivable microbiome of oak affected with Acute Oak Decline. Syst Appl Microbiol. 2016 Oct; 39(7):484-490.

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Sanabria-R?os DJ, Rivera-Torres Y, Rosario J, Gutierrez R, Torres-Garc?a Y, Montano N, Ort?z-Soto G, R?os-Olivares E, Rodr?guez JW, Carballeira NM. Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5067-71.

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Medalla F, Sj?lund-Karlsson M, Shin S, Harvey E, Joyce K, Theobald L, Nygren BN, Pecic G, Gay K, Austin J, Stuart A, Blanton E, Mintz ED, Whichard JM, Barzilay EJ. Ciprofloxacin-resistant Salmonella enterica Serotype Typhi, United States, 1999-2008. Emerg Infect Dis. 2011 Jun; 17(6):1095-8.

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Campbell S, Harada RM, Li QX. Ferrimonas senticii sp. nov., a novel gammaproteobacterium isolated from the mucus of a puffer fish caught in Kaneohe Bay, Hawai'i. Int J Syst Evol Microbiol. 2007 Nov; 57(Pt 11):2670-2673.

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Tran TP, Ellsworth EL, Sanchez JP, Watson BM, Stier MA, Showalter HD, Domagala JM, Shapiro MA, Joannides ET, Gracheck SJ, Nguyen DQ, Bird P, Yip J, Sharadendu A, Ha C, Ramezani S, Wu X, Singh R. Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors. Bioorg Med Chem Lett. 2007 Mar 01; 17(5):1312-20.

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Gibreel A, Tracz DM, Nonaka L, Ngo TM, Connell SR, Taylor DE. Incidence of antibiotic resistance in Campylobacter jejuni isolated in Alberta, Canada, from 1999 to 2002, with special reference to tet(O)-mediated tetracycline resistance. Antimicrob Agents Chemother. 2004 Sep; 48(9):3442-50.

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Zheng X, Johnson C, Lu Y, Yanagihara R, Hollingshead S, Crain M, Benjamin W, Waites KB. Clinical isolates of Streptococcus pneumoniae resistant to levofloxacin contain mutations in both gyrA and parC genes. Int J Antimicrob Agents. 2001 Oct; 18(4):373-8.

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