"Sodium Channel Blockers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
| Descriptor ID |
D026941
|
| MeSH Number(s) |
D27.505.519.562.750 D27.505.954.411.720
|
| Concept/Terms |
Sodium Channel Blockers- Sodium Channel Blockers
- Sodium Channel Inhibitors
- Channel Inhibitors, Sodium
- Inhibitors, Sodium Channel
- Channel Blockers, Sodium
|
Below are MeSH descriptors whose meaning is more general than "Sodium Channel Blockers".
Below are MeSH descriptors whose meaning is more specific than "Sodium Channel Blockers".
This graph shows the total number of publications written about "Sodium Channel Blockers" by people in this website by year, and whether "Sodium Channel Blockers" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 0 | 3 | 3 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sodium Channel Blockers" by people in Profiles.
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Zou L, Xue Y, Jones M, Heinbockel T, Ying M, Zhan X. The Effects of Quinine on Neurophysiological Properties of Dopaminergic Neurons. Neurotox Res. 2018 07; 34(1):62-73.
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Wang ZJ, Tabakoff B, Levinson SR, Heinbockel T. Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions. Acta Pharmacol Sin. 2015 Jul; 36(7):791-9.
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Jim?nez-Rivera CA, Figueroa J, V?zquez-Torres R, V?lez-Hernandez ME, Schwarz D, Vel?squez-Martinez MC, Arencibia-Albite F. Presynaptic inhibition of glutamate transmission by a2 receptors in the VTA. Eur J Neurosci. 2012 May; 35(9):1406-15.
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Epstein M, Calhoun DA. Aldosterone blockers (mineralocorticoid receptor antagonism) and potassium-sparing diuretics. J Clin Hypertens (Greenwich). 2011 Sep; 13(9):644-8.
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Karbat I, Ilan N, Zhang JZ, Cohen L, Kahn R, Benveniste M, Scheuer T, Catterall WA, Gordon D, Gurevitz M. Partial agonist and antagonist activities of a mutant scorpion beta-toxin on sodium channels. J Biol Chem. 2010 Oct 01; 285(40):30531-8.
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Farhang B, Pietruszewski L, Lutfy K, Wagner EJ. The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons. Neuropharmacology. 2010 Sep; 59(3):190-200.
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Barraza D, Kita H, Wilson CJ. Slow spike frequency adaptation in neurons of the rat subthalamic nucleus. J Neurophysiol. 2009 Dec; 102(6):3689-97.
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Goldberg JA, Teagarden MA, Foehring RC, Wilson CJ. Nonequilibrium calcium dynamics regulate the autonomous firing pattern of rat striatal cholinergic interneurons. J Neurosci. 2009 Jul 01; 29(26):8396-407.
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Jiang Q, Li MH, Papasian CJ, Branigan D, Xiong ZG, Wang JQ, Chu XP. Characterization of acid-sensing ion channels in medium spiny neurons of mouse striatum. Neuroscience. 2009 Aug 04; 162(1):55-66.
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Holford M, Zhang MM, Gowd KH, Azam L, Green BR, Watkins M, Ownby JP, Yoshikami D, Bulaj G, Olivera BM. Pruning nature: Biodiversity-derived discovery of novel sodium channel blocking conotoxins from Conus bullatus. Toxicon. 2009 Jan; 53(1):90-8.