"Vinculin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cytoskeletal protein associated with cell-cell and cell-matrix interactions. The amino acid sequence of human vinculin has been determined. The protein consists of 1066 amino acid residues and its gene has been assigned to chromosome 10.
| Descriptor ID |
D016596
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| MeSH Number(s) |
D12.776.220.990
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Vinculin".
Below are MeSH descriptors whose meaning is more specific than "Vinculin".
This graph shows the total number of publications written about "Vinculin" by people in this website by year, and whether "Vinculin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Vinculin" by people in Profiles.
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Hui B, Bu Z, Cheng X. Role of vinculin in the structural dynamics of cadherin-catenin complexes and its implications for F-actin binding. Protein Sci. 2025 Sep; 34(9):e70259.
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Callaway DJE, Nicholl ID, Shi B, Reyes G, Farago B, Bu Z. Nanoscale dynamics of the cadherin-catenin complex bound to vinculin revealed by neutron spin echo spectroscopy. Proc Natl Acad Sci U S A. 2024 Sep 24; 121(39):e2408459121.
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Shi B, Matsui T, Qian S, Weiss TM, Nicholl ID, Callaway DJE, Bu Z. An ensemble of cadherin-catenin-vinculin complex employs vinculin as the major F-actin binding mode. Biophys J. 2023 06 20; 122(12):2456-2474.
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Krokhotin A, Sarker M, Sevilla EA, Costantini LM, Griffith JD, Campbell SL, Dokholyan NV. Distinct Binding Modes of Vinculin Isoforms Underlie Their Functional Differences. Structure. 2019 10 01; 27(10):1527-1536.e3.
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Sarker M, Lee HT, Mei L, Krokhotin A, de Los Reyes SE, Yen L, Costantini LM, Griffith J, Dokholyan NV, Alushin GM, Campbell SL. Cardiomyopathy Mutations in Metavinculin Disrupt Regulation of Vinculin-Induced F-Actin Assemblies. J Mol Biol. 2019 04 05; 431(8):1604-1618.
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Kumar A, Nune KC, Misra RD. Electric field-mediated growth of osteoblasts - the significant impact of dynamic flow of medium. Biomater Sci. 2016 Jan; 4(1):136-44.
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Lele TP, Pendse J, Kumar S, Salanga M, Karavitis J, Ingber DE. Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells. J Cell Physiol. 2006 Apr; 207(1):187-94.
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Galloway PG, Perry G, Gambetti P. Hirano body filaments contain actin and actin-associated proteins. J Neuropathol Exp Neurol. 1987 Mar; 46(2):185-99.