Motor Neuron Disease

"Motor Neuron Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)

Descriptor ID	D016472
MeSH Number(s)	C10.574.562 C10.668.467
Concept/Terms	Motor Neuron Disease Motor Neuron Disease Motor Neuron Diseases Neuron Disease, Motor Neuron Diseases, Motor Motor System Disease Motor System Diseases Familial Motor Neuron Disease Familial Motor Neuron Disease Motor Neuron Disease, Familial Lateral Sclerosis Lateral Sclerosis Lateral Scleroses Scleroses, Lateral Sclerosis, Lateral Primary Lateral Sclerosis Lateral Scleroses, Primary Lateral Sclerosis, Primary Primary Lateral Scleroses Scleroses, Primary Lateral Sclerosis, Primary Lateral Motor Neuron Disease, Upper Motor Neuron Disease, Upper Upper Motor Neuron Disease Motor Neuron Disease, Secondary Motor Neuron Disease, Secondary Secondary Motor Neuron Disease Anterior Horn Cell Disease Anterior Horn Cell Disease Motor Neuron Disease, Lower Motor Neuron Disease, Lower Lower Motor Neuron Disease

Below are MeSH descriptors whose meaning is more general than "Motor Neuron Disease".

Below are MeSH descriptors whose meaning is more specific than "Motor Neuron Disease".

publications

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This graph shows the total number of publications written about "Motor Neuron Disease" by people in this website by year, and whether "Motor Neuron Disease" was a major or minor topic of these publications.

Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 2006 and 2009 and 2013 and 2014 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	0	1	1
2009	1	0	1
2013	0	1	1
2014	1	0	1
2015	1	0	1

Below are the most recent publications written about "Motor Neuron Disease" by people in Profiles.

Strickland AV, Schabhüttl M, Offenbacher H, Synofzik M, Hauser NS, Brunner-Krainz M, Gruber-Sedlmayr U, Moore SA, Windhager R, Bender B, Harms M, Klebe S, Young P, Kennerson M, Garcia AS, Gonzalez MA, Züchner S, Schule R, Shy ME, Auer-Grumbach M. Mutation screen reveals novel variants and expands the phenotypes associated with DYNC1H1. J Neurol. 2015 Sep; 262(9):2124-34.

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Herrmann DN, Horvath R, Sowden JE, Gonzalez M, Gonzales M, Sanchez-Mejias A, Guan Z, Whittaker RG, Almodovar JL, Lane M, Bansagi B, Pyle A, Boczonadi V, Lochmüller H, Griffin H, Chinnery PF, Lloyd TE, Littleton JT, Zuchner S. Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. Am J Hum Genet. 2014 Sep 04; 95(3):332-9.

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Foley AR, Menezes MP, Pandraud A, Gonzalez MA, Al-Odaib A, Abrams AJ, Sugano K, Yonezawa A, Manzur AY, Burns J, Hughes I, McCullagh BG, Jungbluth H, Lim MJ, Lin JP, Megarbane A, Urtizberea JA, Shah AH, Antony J, Webster R, Broomfield A, Ng J, Mathew AA, O'Byrne JJ, Forman E, Scoto M, Prasad M, O'Brien K, Olpin S, Oppenheim M, Hargreaves I, Land JM, Wang MX, Carpenter K, Horvath R, Straub V, Lek M, Gold W, Farrell MO, Brandner S, Phadke R, Matsubara K, McGarvey ML, Scherer SS, Baxter PS, King MD, Clayton P, Rahman S, Reilly MM, Ouvrier RA, Christodoulou J, Züchner S, Muntoni F, Houlden H. Treatable childhood neuronopathy caused by mutations in riboflavin transporter RFVT2. Brain. 2014 Jan; 137(Pt 1):44-56.

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Mojsilovic-Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades SN, Zhou W, Liu Y, Neve RL, Taylor JP, Driscoll M, Clardy J, Merry D, Kalb RG. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 2009 Jun 24; 29(25):8236-47.

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Cardona AE, Pioro EP, Sasse ME, Kostenko V, Cardona SM, Dijkstra IM, Huang D, Kidd G, Dombrowski S, Dutta R, Lee JC, Cook DN, Jung S, Lira SA, Littman DR, Ransohoff RM. Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci. 2006 Jul; 9(7):917-24.

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