Interleukin-6

"Interleukin-6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.

Descriptor ID	D015850
MeSH Number(s)	D12.644.276.374.465.224 D12.776.467.374.465.202 D23.529.374.465.224
Concept/Terms	Interleukin-6 Interleukin-6 Interleukin 6 IL6 B-Cell Stimulatory Factor 2 B-Cell Stimulatory Factor-2 Differentiation Factor-2, B-Cell Differentiation Factor 2, B Cell B-Cell Differentiation Factor-2 B Cell Differentiation Factor 2 BSF-2 Hybridoma Growth Factor Growth Factor, Hybridoma IFN-beta 2 Plasmacytoma Growth Factor Growth Factor, Plasmacytoma Hepatocyte-Stimulating Factor Hepatocyte Stimulating Factor MGI-2 Myeloid Differentiation-Inducing Protein Differentiation-Inducing Protein, Myeloid Myeloid Differentiation Inducing Protein B-Cell Differentiation Factor B Cell Differentiation Factor Differentiation Factor, B-Cell Differentiation Factor, B Cell IL-6 Interferon beta-2 Interferon beta 2 beta-2, Interferon B Cell Stimulatory Factor-2 B Cell Stimulatory Factor 2

Below are MeSH descriptors whose meaning is more general than "Interleukin-6".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-6 [D12.644.276.374.465.224]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-6 [D12.776.467.374.465.202]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-6 [D23.529.374.465.224]

Below are MeSH descriptors whose meaning is related to "Interleukin-6".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-6".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-6" by people in this website by year, and whether "Interleukin-6" was a major or minor topic of these publications.

Bar chart showing 133 publications over 30 distinct years, with a maximum of 10 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1997	2	0	2
1998	1	2	3
1999	0	2	2
2000	1	0	1
2001	2	1	3
2002	1	2	3
2003	0	2	2
2004	1	1	2
2005	0	1	1
2006	1	5	6
2007	2	5	7
2008	3	2	5
2009	4	3	7
2010	1	5	6
2011	3	5	8
2012	5	3	8
2013	3	5	8
2014	2	8	10
2015	0	6	6
2016	0	5	5
2017	2	5	7
2018	1	1	2
2019	0	3	3
2020	0	2	2
2021	2	2	4
2022	0	7	7
2023	1	2	3
2024	3	2	5
2025	1	3	4

Below are the most recent publications written about "Interleukin-6" by people in Profiles.

Song S, Kim Z, Youn HJ, Cho J, Kim YS, Min JW, Choi SW, Franke AA, Jun S, Joung H, Lee JE. Dietary intake and plasma isoflavones are inversely associated with inflammatory markers in breast cancer survivors: A cross-sectional study. Nutr Res. 2025 Jun; 138:22-32.

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Ghanooni D, Carrico AW, Flentje A, Moreno PI, Harkness A, Dilworth S, Pahwa S, Pallikkuth S, Regan S, Aouizerat BE, Duncan DT. Neighborhood-level adversity and inflammation among sexual minority men living with HIV. Health Psychol. 2025 Mar; 44(3):188-196.

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Li T, Song X, Chen J, Li Y, Lin J, Li P, Yu S, Durojaye OA, Yang F, Liu X, Li J, Cheng S, Yao X, Ding X. Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway. Int J Biol Sci. 2025; 21(1):285-305.

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Lee KCY, Williams AL, Hara A, Khadka VS, Hayashi J, Shohet RV. Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart. Physiol Rep. 2025 Jan; 13(1):e70193.

View in: PubMed
Ryan AK, Rahman S, Williams RM. Optical Aptamer-Based Cytokine Nanosensor Detects Macrophage Activation by Bacterial Toxins. ACS Sens. 2024 07 26; 9(7):3697-3706.

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Gaikwad P, Rahman N, Parikh R, Crespo J, Cohen Z, Williams RM. Optical Nanosensor Passivation Enables Highly Sensitive Detection of the Inflammatory Cytokine Interleukin-6. ACS Appl Mater Interfaces. 2024 May 29; 16(21):27102-27113.

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Kim M, McCann JJ, Fortner J, Randall E, Chen C, Chen Y, Yaari Z, Wang Y, Koder RL, Heller DA. Quantum Defect Sensitization via Phase-Changing Supercharged Antibody Fragments. J Am Chem Soc. 2024 05 08; 146(18):12454-12462.

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Ouhara K, Takemura T, Taniguchi Y, Fujimori R, Tamura T, Akane Y, Matsuda S, Hamamoto Y, Shintani T, Kajiya M, Munenaga S, Iwata T, Fujita T, Mizuno N. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model. Oral Dis. 2024 11; 30(8):5294-5304.

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Zhu HT, Luo J, Peng Y, Cheng XF, Wu SZ, Zhao YD, Chang L, Sun ZJ, Dong DL. Nitazoxanide protects against experimental ulcerative colitis through improving intestinal barrier and inhibiting inflammation. Chem Biol Interact. 2024 May 25; 395:111013.

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Zhu N, Mealka M, Mitchel S, Milani C, Acu?a LM, Rogers E, Lahana AN, Huxford T. X-ray Crystallographic Study of Preferred Spacing by the NF-?B p50 Homodimer on ?B DNA. Biomolecules. 2023 08 26; 13(9).

View in: PubMed

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