Steroid 12-alpha-Hydroxylase
"Steroid 12-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.
| Descriptor ID |
D013253
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| MeSH Number(s) |
D08.244.453.900.500 D08.244.453.915.730 D08.811.682.690.708.170.900.500 D08.811.682.690.708.170.915.730 D12.776.422.220.453.900.500 D12.776.422.220.453.915.730
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| Concept/Terms |
Steroid 12-alpha-Hydroxylase- Steroid 12-alpha-Hydroxylase
- Steroid 12 alpha Hydroxylase
- Steroid 12-Monooxygenase
- Steroid 12-Hydroxylase
- Steroid-12-Hydroxylase
- Steroid 12 Hydroxylase
- CYP8B1
- Sterol 12 alpha-Hydroxylase
- 12 alpha-Hydroxylase, Sterol
- Sterol 12 alpha Hydroxylase
- alpha-Hydroxylase, Sterol 12
- Sterol 12-alpha-Hydroxylase
- 12-alpha-Hydroxylase
- 12 alpha Hydroxylase
- 12alpha-Hydroxylase
- 12alpha Hydroxylase
- Cytochrome P450 8B1
- Steroid-12-Monooxygenase
- Steroid 12 Monooxygenase
- Cytochrome P450 CYP8B1
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Below are MeSH descriptors whose meaning is more general than "Steroid 12-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Steroid 12-alpha-Hydroxylase".
This graph shows the total number of publications written about "Steroid 12-alpha-Hydroxylase" by people in this website by year, and whether "Steroid 12-alpha-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Steroid 12-alpha-Hydroxylase" by people in Profiles.
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Offei SD, Arman HD, Baig MO, Chavez LS, Paladini CA, Yoshimoto FK. Chemical synthesis of 7-oxygenated 12a-hydroxy steroid derivatives to enable the biochemical characterization of cytochrome P450 8B1, the oxysterol 12a-hydroxylase enzyme implicated in cardiovascular health and obesity. Steroids. 2018 12; 140:185-195.
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Gyamfi MA, Wan YJ. Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis. J Biol Chem. 2009 Apr 03; 284(14):9321-30.