"Leupeptins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of acylated oligopeptides produced by Actinomycetes that function as protease inhibitors. They have been known to inhibit to varying degrees trypsin, plasmin, KALLIKREINS, papain and the cathepsins.
| Descriptor ID |
D007976
|
| MeSH Number(s) |
D12.644.456.580
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Leupeptins".
Below are MeSH descriptors whose meaning is more specific than "Leupeptins".
This graph shows the total number of publications written about "Leupeptins" by people in this website by year, and whether "Leupeptins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1999 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
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click here.
Below are the most recent publications written about "Leupeptins" by people in Profiles.
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Dugue R, Hassen GW, Shulman A, Goodman JH, Michelson H, Serrano P, Chauhan S, Ling DSF. Controlled cortical impact-induced neurodegeneration decreases after administration of the novel calpain-inhibitor Gabadur. Brain Res Bull. 2018 09; 142:368-373.
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Burroughs AF, Eluhu S, Whalen D, Goodwin JS, Sakwe AM, Arinze IJ. PML-Nuclear Bodies Regulate the Stability of the Fusion Protein Dendra2-Nrf2 in the Nucleus. Cell Physiol Biochem. 2018; 47(2):800-816.
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Velma V, Broome HJ, Hebert MD. Regulated specific proteolysis of the Cajal body marker protein coilin. Chromosoma. 2012 Dec; 121(6):629-42.
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Benavides M, Chow-Tsang LF, Zhang J, Zhong H. The novel interaction between microspherule protein Msp58 and ubiquitin E3 ligase EDD regulates cell cycle progression. Biochim Biophys Acta. 2013 Jan; 1833(1):21-32.
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Pasten C, Rosa R, Ortiz S, Gonz?lez S, Garc?a-Arrar?s JE. Characterization of proteolytic activities during intestinal regeneration of the sea cucumber, Holothuria glaberrima. Int J Dev Biol. 2012; 56(9):681-91.
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Liou GY, Zhang H, Miller EM, Seibold SA, Chen W, Gallo KA. Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling. Biochem J. 2010 Apr 14; 427(3):435-43.
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Meller R, Cameron JA, Torrey DJ, Clayton CE, Ordonez AN, Henshall DC, Minami M, Schindler CK, Saugstad JA, Simon RP. Rapid degradation of Bim by the ubiquitin-proteasome pathway mediates short-term ischemic tolerance in cultured neurons. J Biol Chem. 2006 Mar 17; 281(11):7429-36.
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Liu B, Yu X, Luo K, Yu Y, Yu XF. Influence of primate lentiviral Vif and proteasome inhibitors on human immunodeficiency virus type 1 virion packaging of APOBEC3G. J Virol. 2004 Feb; 78(4):2072-81.
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Rice PL, Kelloff J, Sullivan H, Driggers LJ, Beard KS, Kuwada S, Piazza G, Ahnen DJ. Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells. Mol Cancer Ther. 2003 Sep; 2(9):885-92.
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Wang HF, Figueiredo Pereira ME, Correia MA. Cytochrome P450 3A degradation in isolated rat hepatocytes: 26S proteasome inhibitors as probes. Arch Biochem Biophys. 1999 May 01; 365(1):45-53.