Flagellin

"Flagellin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein with a molecular weight of 40,000 isolated from bacterial flagella. At appropriate pH and salt concentration, three flagellin monomers can spontaneously reaggregate to form structures which appear identical to intact flagella.

Descriptor ID	D005408
MeSH Number(s)	D12.776.097.380
Concept/Terms	Flagellin Flagellin

Below are MeSH descriptors whose meaning is more general than "Flagellin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Bacterial Proteins [D12.776.097]
Flagellin [D12.776.097.380]

Below are MeSH descriptors whose meaning is more specific than "Flagellin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Flagellin" by people in this website by year, and whether "Flagellin" was a major or minor topic of these publications.

Bar chart showing 12 publications over 11 distinct years, with a maximum of 2 publications in 1998

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	1	2
2000	0	1	1
2001	0	1	1
2005	0	1	1
2006	1	0	1
2011	0	1	1
2014	1	0	1
2015	1	0	1
2018	1	0	1
2019	1	0	1
2025	0	1	1

Below are the most recent publications written about "Flagellin" by people in Profiles.

Guo W, Zhang S, Park JH, Stanton V, Asp M, Herrera H, Tai JB, Yue J, Wang J, Guo J, Kumar R, Botting JM, Wu S, Yan J, Klose KE, Yildiz FH, Liu J. Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae. Nat Microbiol. 2025 Dec; 10(12):3305-3314.

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Stanton V, Himes B, Mejia-Santana A, Eppinger M, Romo J, Xing J, Zhulin IB, Cai H, Wang Y, Inniss Nl, Minasov G, Satchell KJF, Klose KE. The PAS domain of the polarly localized histidine kinase FlrB in Vibrio cholerae controls class III flagellar transcription and contributes to intestinal colonization. mBio. 2025 Nov 12; 16(11):e0237925.

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Sharma P, Levy O, Dowling DJ. The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice. Front Immunol. 2020; 11:171.

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Gries CM, Mohan RR, Morikis D, Lo DD. Crosslinked flagella as a stabilized vaccine adjuvant scaffold. BMC Biotechnol. 2019 07 18; 19(1):48.

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Echazarreta MA, Kepple JL, Yen LH, Chen Y, Klose KE. A Critical Region in the FlaA Flagellin Facilitates Filament Formation of the Vibrio cholerae Flagellum. J Bacteriol. 2018 08 01; 200(15).

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Wang H, Silva AJ, Benitez JA. 3-Amino 1,8-naphthalimide, a structural analog of the anti-cholera drug virstatin inhibits chemically-biased swimming and swarming motility in vibrios. Microbes Infect. 2017 06; 19(6):370-375.

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Bennett KM, Gorham RD, Gusti V, Trinh L, Morikis D, Lo DD. Hybrid flagellin as a T cell independent vaccine scaffold. BMC Biotechnol. 2015 Aug 12; 15:71.

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Cunningham AL, Dang KM, Yu JJ, Guentzel MN, Heidner HW, Klose KE, Arulanandam BP. Enhancement of vaccine efficacy by expression of a TLR5 ligand in the defined live attenuated Francisella tularensis subsp. novicida strain U112?iglB::fljB. Vaccine. 2014 Sep 08; 32(40):5234-40.

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Burch AY, Shimada BK, Mullin SW, Dunlap CA, Bowman MJ, Lindow SE. Pseudomonas syringae coordinates production of a motility-enabling surfactant with flagellar assembly. J Bacteriol. 2012 Mar; 194(6):1287-98.

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Xicohtencatl-Cort?s J, Lyons S, Chaparro AP, Hern?ndez DR, Salda?a Z, Ledesma MA, Rend?n MA, Gewirtz AT, Klose KE, Gir?n JA. Identification of proinflammatory flagellin proteins in supernatants of Vibrio cholerae O1 by proteomics analysis. Mol Cell Proteomics. 2006 Dec; 5(12):2374-83.

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