Drug Synergism

"Drug Synergism" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The action of a drug in promoting or enhancing the effectiveness of another drug.

Descriptor ID	D004357
MeSH Number(s)	G07.690.773.968.477
Concept/Terms	Drug Synergism Drug Synergism Drug Synergisms Synergism, Drug Synergisms, Drug Drug Potentiation Drug Potentiation Drug Potentiations Potentiation, Drug Potentiations, Drug Drug Augmentation Drug Augmentation Augmentation, Drug Augmentations, Drug Drug Augmentations

Below are MeSH descriptors whose meaning is more general than "Drug Synergism".

Biological Sciences [G]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Drug Interactions [G07.690.773.968]
Drug Synergism [G07.690.773.968.477]

Below are MeSH descriptors whose meaning is related to "Drug Synergism".

Below are MeSH descriptors whose meaning is more specific than "Drug Synergism".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Drug Synergism" by people in this website by year, and whether "Drug Synergism" was a major or minor topic of these publications.

Bar chart showing 136 publications over 30 distinct years, with a maximum of 9 publications in 2010 and 2013 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	2	2
1997	0	3	3
1998	0	1	1
2000	0	2	2
2001	0	3	3
2002	0	3	3
2003	0	5	5
2004	1	3	4
2005	0	8	8
2006	0	4	4
2007	1	4	5
2008	0	4	4
2009	1	1	2
2010	0	9	9
2011	0	8	8
2012	0	7	7
2013	0	9	9
2014	1	7	8
2015	0	8	8
2016	0	8	8
2017	1	5	6
2018	1	8	9
2019	0	3	3
2020	0	4	4
2021	0	2	2
2022	0	2	2
2023	0	2	2
2024	2	1	3
2025	0	1	1
2026	0	1	1

Below are the most recent publications written about "Drug Synergism" by people in Profiles.

Gao Y, Chen W, Zarogoulidis P, Yallapu MM, Nikolic MV, Vaishnani DK, Zheng J, Nedeljkovic N, Ye K, Guo Y, Xu Q. Multiomics and experimental validation reveal theophylline's mechanism targeting IL1A/ACTB/TLR4 and identify synergistic drugs in hepatocellular carcinoma. J Pharmacol Exp Ther. 2026 Mar; 393(3):103836.

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Singh A, Natu A, Anthony F, Muthu H, Khade B, Smoot DT, Ashktorab H, Gupta S. The synergistic action of HDAC inhibitor with cisplatin impedes survival and proliferation of drug-tolerant persister in gastric and liver cancer cells. Clin Epigenetics. 2025 Oct 08; 17(1):168.

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Rosado-Qui?ones AM, Col?n-Lorenzo EE, Pala ZR, Bosch J, Kudyba K, Kudyba H, Leed SE, Roncal N, Baerga-Ortiz A, Roche-Lima A, Gerena Y, Fidock DA, Roth A, Vega-Rodr?guez J, Serrano AE. Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs. Antimicrob Agents Chemother. 2024 06 05; 68(6):e0164323.

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Salim A, Hennessy E, Sonneborn C, Hogue O, Biswas S, Mays M, Suneja A, Ahmed Z, Mata IF. Synergism of Anti-CGRP Monoclonal Antibodies and OnabotulinumtoxinA in the Treatment of Chronic Migraine: A Real-World Retrospective Chart Review. CNS Drugs. 2024 Jun; 38(6):481-491.

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Roche-Lima A, Rosado-Qui?ones AM, Feliu-Maldonado RA, Figueroa-Gispert MDM, D?az-Rivera J, D?az-Gonz?lez RG, Carrasquillo-Carrion K, Nieves BG, Col?n-Lorenzo EE, Serrano AE. Antimalarial Drug Combination Predictions Using the Machine Learning Synergy Predictor (MLSyPred?) tool. Acta Parasitol. 2024 Mar; 69(1):415-425.

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Peat TJ, Gaikwad SM, Dubois W, Gyabaah-Kessie N, Zhang S, Gorjifard S, Phyo Z, Andres M, Hughitt VK, Simpson RM, Miller MA, Girvin AT, Taylor A, Williams D, D'Antonio N, Zhang Y, Rajagopalan A, Flietner E, Wilson K, Zhang X, Shinn P, Klumpp-Thomas C, McKnight C, Itkin Z, Chen L, Kazandijian D, Zhang J, Michalowski AM, Simmons JK, Keats J, Thomas CJ, Mock BA. Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma. Cancer Lett. 2023 08 01; 568:216284.

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Xiao CY, Lan JE, Liu X, Sun ZL, Li XJ, Yin YH, Gibbons S, Mu Q. Acetylenic spiroketal enol ethers from Artemisia rupestris and their synergistic antibacterial effects on methicillin-resistant Staphylococcus aureus. Nat Prod Res. 2024 Feb-Mar; 38(4):589-593.

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Dasari S, Njiki S, Mbemi A, Yedjou CG, Tchounwou PB. Pharmacological Effects of Cisplatin Combination with Natural Products in Cancer Chemotherapy. Int J Mol Sci. 2022 Jan 28; 23(3).

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Kolawole OR, Kashfi K. NSAIDs and Cancer Resolution: New Paradigms beyond Cyclooxygenase. Int J Mol Sci. 2022 Jan 27; 23(3).

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Han HW, Patel KD, Kwak JH, Jun SK, Jang TS, Lee SH, Knowles JC, Kim HW, Lee HH, Lee JH. Selenium Nanoparticles as Candidates for Antibacterial Substitutes and Supplements against Multidrug-Resistant Bacteria. Biomolecules. 2021 07 14; 11(7).

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