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Michelle Tallquist, PHD

Faculty RankProfessor
InstitutionUniversity of Hawaii
DepartmentThe Center for Cardiovascular Research
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI
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    Collapse Research 
    Collapse research activities and funding
    R01HL074257     (TALLQUIST, MICHELLE D)Apr 1, 2009 - Jun 30, 2017
    PDGF Receptor Signaling in Mammalian Development
    Role: Principal Investigator

    K12HL143960     (SHIKUMA, CECILIA M.)Aug 1, 2018 - Jun 30, 2023
    Hawaii Interdisciplinary Mentored Career Development in HIV Co-Morbidities
    Role: Co-Principal Investigator

    R01HL144067     (TALLQUIST, MICHELLE D)Aug 11, 2018 - Jun 30, 2022
    Regulation of cardiac inflammation by fibroblasts
    Role: Principal Investigator

    R21HL156112     (TALLQUIST, MICHELLE D)Feb 1, 2021 - Jan 31, 2023
    The role of lung lipofibroblasts in alveolar differentiation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Francisco J, Zhang Y, Jeong JI, Mizushima W, Ikeda S, Ivessa A, Oka S, Zhai P, Tallquist MD, Del Re DP. Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition. JACC Basic Transl Sci. 2020 Sep; 5(9):931-945. PMID: 33015415.
    2. Tallquist MD. Developmental Pathways of Cardiac Fibroblasts. Cold Spring Harb Perspect Biol. 2020 04 01; 12(4). PMID: 31570334.
      Citations:    Fields:    
    3. Tallquist MD. Cardiac Fibroblast Diversity. Annu Rev Physiol. 2020 02 10; 82:63-78. PMID: 32040933.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    4. Wirka RC, Wagh D, Paik DT, Pjanic M, Nguyen T, Miller CL, Kundu R, Nagao M, Coller J, Koyano TK, Fong R, Woo YJ, Liu B, Montgomery SB, Wu JC, Zhu K, Chang R, Alamprese M, Tallquist MD, Kim JB, Quertermous T. Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis. Nat Med. 2019 08; 25(8):1280-1289. PMID: 31359001.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    5. Ivey MJ, Kuwabara JT, Riggsbee KL, Tallquist MD. Platelet-derived growth factor receptor-a is essential for cardiac fibroblast survival. . 2019 08 01; 317(2):H330-H344. PMID: 31125253.
    6. Park J, Ivey MJ, Deana Y, Riggsbee KL, Sörensen E, Schwabl V, Sjöberg C, Hjertberg T, Park GY, Swonger JM, Rosengreen T, Morty RE, Ahlbrecht K, Tallquist MD. The Tcf21 lineage constitutes the lung lipofibroblast population. Am J Physiol Lung Cell Mol Physiol. 2019 05 01; 316(5):L872-L885. PMID: 30675802.
      Citations: 6     Fields:    Translation:AnimalsCells
    7. Green CD, Ma Q, Manske GL, Shami AN, Zheng X, Marini S, Moritz L, Sultan C, Gurczynski SJ, Moore BB, Tallquist MD, Li JZ, Hammoud SS. A Comprehensive Roadmap of Murine Spermatogenesis Defined by Single-Cell RNA-Seq. Dev Cell. 2018 09 10; 46(5):651-667.e10. PMID: 30146481.
      Citations: 45     Fields:    Translation:AnimalsCells
    8. Tallquist MD. Cardiac fibroblasts: from origin to injury. Curr Opin Physiol. 2018 Feb; 1:75-79. PMID: 29527587.
    9. Ivey MJ, Kuwabara JT, Pai JT, Moore RE, Sun Z, Tallquist MD. Resident fibroblast expansion during cardiac growth and remodeling. J Mol Cell Cardiol. 2018 01; 114:161-174. PMID: 29158033.
      Citations: 30     Fields:    Translation:AnimalsCells
    10. Kuwabara JT, Tallquist MD. Tracking Adventitial Fibroblast Contribution to Disease: A Review of Current Methods to Identify Resident Fibroblasts. Arterioscler Thromb Vasc Biol. 2017 09; 37(9):1598-1607. PMID: 28705796.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    11. Tallquist MD, Molkentin JD. Redefining the identity of cardiac fibroblasts. Nat Rev Cardiol. 2017 Aug; 14(8):484-491. PMID: 28436487.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    12. Ivey MJ, Tallquist MD. Defining the Cardiac Fibroblast. Circ J. 2016 Oct 25; 80(11):2269-2276. PMID: 27746422.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    13. Ruiz-Camp J, Rodríguez-Castillo JA, Herold S, Mayer K, Vadász I, Tallquist MD, Seeger W, Ahlbrecht K, Morty RE. Tamoxifen dosing for Cre-mediated recombination in experimental bronchopulmonary dysplasia. Transgenic Res. 2017 02; 26(1):165-170. PMID: 27730498.
      Citations: 4     Fields:    Translation:HumansAnimals
    14. Kanisicak O, Khalil H, Ivey MJ, Karch J, Maliken BD, Correll RN, Brody MJ, J Lin SC, Aronow BJ, Tallquist MD, Molkentin JD. Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nat Commun. 2016 07 22; 7:12260. PMID: 27447449.
      Citations: 184     Fields:    Translation:AnimalsCells
    15. Swonger JM, Liu JS, Ivey MJ, Tallquist MD. Genetic tools for identifying and manipulating fibroblasts in the mouse. Differentiation. 2016 Sep; 92(3):66-83. PMID: 27342817.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    16. McCarthy N, Liu JS, Richarte AM, Eskiocak B, Lovely CB, Tallquist MD, Eberhart JK. Pdgfra and Pdgfrb genetically interact during craniofacial development. Dev Dyn. 2016 06; 245(6):641-52. PMID: 26971580.
      Citations: 13     Fields:    Translation:AnimalsCells
    17. Pinto AR, Ilinykh A, Ivey MJ, Kuwabara JT, D'Antoni ML, Debuque R, Chandran A, Wang L, Arora K, Rosenthal NA, Tallquist MD. Revisiting Cardiac Cellular Composition. Circ Res. 2016 Feb 05; 118(3):400-9. PMID: 26635390.
      Citations: 275     Fields:    Translation:HumansAnimalsCells
    18. Vicente-Steijn R, Scherptong RW, Kruithof BP, Duim SN, Goumans MJ, Wisse LJ, Zhou B, Pu WT, Poelmann RE, Schalij MJ, Tallquist MD, Gittenberger-de Groot AC, Jongbloed MR. Regional differences in WT-1 and Tcf21 expression during ventricular development: implications for myocardial compaction. PLoS One. 2015; 10(9):e0136025. PMID: 26390289.
      Citations: 7     Fields:    Translation:AnimalsCells
    19. Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T. Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells that Contribute to the Fibrous Cap. Genom Data. 2015 Sep 01; 5:36-37. PMID: 26090325.
    20. Nurnberg ST, Cheng K, Raiesdana A, Kundu R, Miller CL, Kim JB, Arora K, Carcamo-Oribe I, Xiong Y, Tellakula N, Nanda V, Murthy N, Boisvert WA, Hedin U, Perisic L, Aldi S, Maegdefessel L, Pjanic M, Owens GK, Tallquist MD, Quertermous T. Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. PLoS Genet. 2015 May; 11(5):e1005155. PMID: 26020946.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    21. Ten Freyhaus H, Berghausen EM, Janssen W, Leuchs M, Zierden M, Murmann K, Klinke A, Vantler M, Caglayan E, Kramer T, Baldus S, Schermuly RT, Tallquist MD, Rosenkranz S. Genetic Ablation of PDGF-Dependent Signaling Pathways Abolishes Vascular Remodeling and Experimental Pulmonary Hypertension. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1236-45. PMID: 25745058.
      Citations: 10     Fields:    Translation:AnimalsCells
    22. Moore-Morris T, Tallquist MD, Evans SM. Sorting out where fibroblasts come from. Circ Res. 2014 Sep 12; 115(7):602-4. PMID: 25214570.
      Citations: 7     Fields:    Translation:AnimalsCells
    23. Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M. Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development. 2014 Jan; 141(2):281-95. PMID: 24335256.
      Citations: 19     Fields:    Translation:AnimalsCells
    24. Neubauer B, Machura K, Rupp V, Tallquist MD, Betsholtz C, Sequeira-Lopez ML, Ariel Gomez R, Wagner C. Development of renal renin-expressing cells does not involve PDGF-B-PDGFR-ß signaling. Physiol Rep. 2013 Oct; 1(5):e00132. PMID: 24303195.
      Citations: 6     Fields:    
    25. Wood MA, Acharya A, Finco I, Swonger JM, Elston MJ, Tallquist MD, Hammer GD. Fetal adrenal capsular cells serve as progenitor cells for steroidogenic and stromal adrenocortical cell lineages in M. musculus. Development. 2013 Nov; 140(22):4522-32. PMID: 24131628.
      Citations: 27     Fields:    Translation:AnimalsCells
    26. Krautler NJ, Kana V, Kranich J, Tian Y, Perera D, Lemm D, Schwarz P, Armulik A, Browning JL, Tallquist M, Buch T, Oliveira-Martins JB, Zhu C, Hermann M, Wagner U, Brink R, Heikenwalder M, Aguzzi A. Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell. 2012 Jul 06; 150(1):194-206. PMID: 22770220.
      Citations: 128     Fields:    Translation:AnimalsCells
    27. Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature. 2012 May 13; 485(7400):599-604. PMID: 22660318.
      Citations: 456     Fields:    Translation:AnimalsCells
    28. Acharya A, Baek ST, Huang G, Eskiocak B, Goetsch S, Sung CY, Banfi S, Sauer MF, Olsen GS, Duffield JS, Olson EN, Tallquist MD. The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors. Development. 2012 Jun; 139(12):2139-49. PMID: 22573622.
      Citations: 153     Fields:    Translation:AnimalsCells
    29. Baek ST, Tallquist MD. Nf1 limits epicardial derivative expansion by regulating epithelial to mesenchymal transition and proliferation. Development. 2012 Jun; 139(11):2040-9. PMID: 22535408.
      Citations: 14     Fields:    Translation:AnimalsCells
    30. Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK. Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev Cell. 2012 Mar 13; 22(3):651-9. PMID: 22387002.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    31. Acharya A, Baek ST, Banfi S, Eskiocak B, Tallquist MD. Efficient inducible Cre-mediated recombination in Tcf21 cell lineages in the heart and kidney. Genesis. 2011 Nov; 49(11):870-7. PMID: 21432986.
      Citations: 63     Fields:    Translation:AnimalsCells
    32. Caglayan E, Vantler M, Leppänen O, Gerhardt F, Mustafov L, Ten Freyhaus H, Kappert K, Odenthal M, Zimmermann WH, Tallquist MD, Rosenkranz S. Disruption of platelet-derived growth factor-dependent phosphatidylinositol 3-kinase and phospholipase C? 1 activity abolishes vascular smooth muscle cell proliferation and migration and attenuates neointima formation in vivo. J Am Coll Cardiol. 2011 Jun 21; 57(25):2527-38. PMID: 21679854.
      Citations: 18     Fields:    Translation:AnimalsCells
    33. Smith CL, Baek ST, Sung CY, Tallquist MD. Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling. Circ Res. 2011 Jun 10; 108(12):e15-26. PMID: 21512159.
      Citations: 126     Fields:    Translation:AnimalsCells
    34. Smith CL, Tallquist MD. PDGF function in diverse neural crest cell populations. Cell Adh Migr. 2010 Oct-Dec; 4(4):561-6. PMID: 20657170.
      Citations: 20     Fields:    Translation:HumansAnimals
    35. Wu M, Smith CL, Hall JA, Lee I, Luby-Phelps K, Tallquist MD. Epicardial spindle orientation controls cell entry into the myocardium. Dev Cell. 2010 Jul 20; 19(1):114-25. PMID: 20643355.
      Citations: 43     Fields:    Translation:AnimalsCells
    36. Zhou L, Takayama Y, Boucher P, Tallquist MD, Herz J. LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One. 2009 Sep 09; 4(9):e6922. PMID: 19742316.
      Citations: 37     Fields:    Translation:AnimalsCells
    37. Zovein AC, Hofmann JJ, Lynch M, French WJ, Turlo KA, Yang Y, Becker MS, Zanetta L, Dejana E, Gasson JC, Tallquist MD, Iruela-Arispe ML. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell. 2008 Dec 04; 3(6):625-36. PMID: 19041779.
      Citations: 251     Fields:    Translation:AnimalsCells
    38. Mellgren AM, Smith CL, Olsen GS, Eskiocak B, Zhou B, Kazi MN, Ruiz FR, Pu WT, Tallquist MD. Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res. 2008 Dec 05; 103(12):1393-401. PMID: 18948621.
      Citations: 84     Fields:    Translation:AnimalsCells
    39. Tang W, Zeve D, Suh JM, Bosnakovski D, Kyba M, Hammer RE, Tallquist MD, Graff JM. White fat progenitor cells reside in the adipose vasculature. Science. 2008 Oct 24; 322(5901):583-6. PMID: 18801968.
      Citations: 415     Fields:    Translation:AnimalsCells
    40. French WJ, Creemers EE, Tallquist MD. Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol. 2008 Sep; 28(18):5646-57. PMID: 18606782.
      Citations: 19     Fields:    Translation:AnimalsCells
    41. Pickett EA, Olsen GS, Tallquist MD. Disruption of PDGFRalpha-initiated PI3K activation and migration of somite derivatives leads to spina bifida. Development. 2008 Feb; 135(3):589-98. PMID: 18192285.
      Citations: 20     Fields:    Translation:AnimalsCells
    42. Richarte AM, Mead HB, Tallquist MD. Cooperation between the PDGF receptors in cardiac neural crest cell migration. Dev Biol. 2007 Jun 15; 306(2):785-96. PMID: 17499702.
      Citations: 32     Fields:    Translation:AnimalsCells
    43. Chen Y, Balasubramaniyan V, Peng J, Hurlock EC, Tallquist M, Li J, Lu QR. Isolation and culture of rat and mouse oligodendrocyte precursor cells. Nat Protoc. 2007; 2(5):1044-51. PMID: 17546009.
      Citations: 142     Fields:    Translation:AnimalsCells
    44. Tallquist M, Kazlauskas A. PDGF signaling in cells and mice. Cytokine Growth Factor Rev. 2004 Aug; 15(4):205-13. PMID: 15207812.
      Citations: 149     Fields:    Translation:AnimalsCells
    45. Tallquist MD, French WJ, Soriano P. Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development. PLoS Biol. 2003 Nov; 1(2):E52. PMID: 14624252.
      Citations: 77     Fields:    Translation:AnimalsCells
    46. Tallquist MD, Soriano P. Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development. 2003 Feb; 130(3):507-18. PMID: 12490557.
      Citations: 99     Fields:    Translation:Animals
    47. Morris SM, Tallquist MD, Rock CO, Cooper JA. Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport. EMBO J. 2002 Apr 02; 21(7):1555-64. PMID: 11927540.
      Citations: 74     Fields:    Translation:Animals
    48. Mishina Y, Hanks MC, Miura S, Tallquist MD, Behringer RR. Generation of Bmpr/Alk3 conditional knockout mice. Genesis. 2002 Feb; 32(2):69-72. PMID: 11857780.
      Citations: 122     Fields:    Translation:Animals
    49. Yun TJ, Tallquist MD, Aicher A, Rafferty KL, Marshall AJ, Moon JJ, Ewings ME, Mohaupt M, Herring SW, Clark EA. Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. J Immunol. 2001 Feb 01; 166(3):1482-91. PMID: 11160187.
      Citations: 41     Fields:    Translation:AnimalsCells
    50. Tallquist MD, Klinghoffer RA, Heuchel R, Mueting-Nelsen PF, Corrin PD, Heldin CH, Johnson RJ, Soriano P. Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways. Genes Dev. 2000 Dec 15; 14(24):3179-90. PMID: 11124809.
      Citations: 21     Fields:    Translation:AnimalsCells
    51. Tallquist MD, Weismann KE, Hellström M, Soriano P. Early myotome specification regulates PDGFA expression and axial skeleton development. Development. 2000 Dec; 127(23):5059-70. PMID: 11060232.
      Citations: 107     Fields:    Translation:HumansAnimals
    52. Tallquist MD, Soriano P. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis. 2000 Feb; 26(2):113-5. PMID: 10686601.
      Citations: 200     Fields:    Translation:Animals
    53. Kuhns ST, Tallquist MD, Johnson AJ, Mendez-Fernandez Y, Pease LR. T cell receptor interactions with class I heavy-chain influence T cell selection. Proc Natl Acad Sci U S A. 2000 Jan 18; 97(2):756-60. PMID: 10639152.
      Citations:    Fields:    Translation:HumansAnimalsCells
    54. Tallquist MD, Soriano P, Klinghoffer RA. Growth factor signaling pathways in vascular development. Oncogene. 1999 Dec 20; 18(55):7917-32. PMID: 10630644.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    55. Andrews A, Balciunaite E, Leong FL, Tallquist M, Soriano P, Refojo M, Kazlauskas A. Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci. 1999 Oct; 40(11):2683-9. PMID: 10509666.
      Citations: 44     Fields:    Translation:AnimalsCells
    56. Heuchel R, Berg A, Tallquist M, Ahlén K, Reed RK, Rubin K, Claesson-Welsh L, Heldin CH, Soriano P. Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11410-5. PMID: 10500190.
      Citations: 40     Fields:    Translation:AnimalsCells
    57. Garcia KC, Tallquist MD, Pease LR, Brunmark A, Scott CA, Degano M, Stura EA, Peterson PA, Wilson IA, Teyton L. Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization. Proc Natl Acad Sci U S A. 1997 Dec 09; 94(25):13838-43. PMID: 9391114.
      Citations: 50     Fields:    Translation:AnimalsCells
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