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Deok-Soo Son
Title Associate Professor
Faculty Rank Tenure-Track
Degree PhD
Institution Meharry Medical College
Department Biochemistry and Cancer Biology
Clusters Cancer
Genes and Environmental Health/Toxicology
Obesity and Metabolic Syndromes
Women's Health and Reproductive Biology
Address
1005 Dr DB Todd Jr Blvd
City Nashville
State TN
Postal Code 37208
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1. Ignacio RMC, Dong YL, Kabir SM, Choi H, Lee ES, Wilson AJ, Beeghly-Fadiel A, Whalen MM, Son DS. CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. Oncotarget. 2018 Feb 09; 9(11):9751-9765.
2. Pajarillo E, Johnson J, Kim J, Karki P, Son DS, Aschner M, Lee E. 17ß-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology. 2018 Mar; 65:280-288.
3. Karki P, Hong P, Johnson J, Pajarillo E, Son DS, Aschner M, Lee EY. Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-?B Pathways. Mol Neurobiol. 2017 Aug 15.
4. Choi H, Ignacio RMC, Lee ES, Roby KF, Terranova PF, Son DS. Localization of Serum Amyloid A3 in the Mouse Ovary. Immune Netw. 2017 Aug; 17(4):261-268.
5. Johnson J, Pajarillo EAB, Taka E, Reams R, Son DS, Aschner M, Lee E. Valproate and sodium butyrate attenuate manganese-decreased locomotor activity and astrocytic glutamate transporters expression in mice. Neurotoxicology. 2018 Jan; 64:230-239.
6. Choi H, Ignacio RMC, Lee ES, Wilson AJ, Khabele D, Son DS. Augmented Serum Amyloid A1/2 Mediated by TNF-induced NF-?B in Human Serous Ovarian Epithelial Tumors. Immune Netw. 2017 Apr; 17(2):121-127.
7. Ignacio RM, Kabir SM, Lee ES, Adunyah SE, Son DS. NF-?B-Mediated CCL20 Reigns Dominantly in CXCR2-Driven Ovarian Cancer Progression. PLoS One. 2016; 11(10):e0164189.
8. Ignacio RM, Gibbs CR, Lee ES, Son DS. Differential Chemokine Signature between Human Preadipocytes and Adipocytes. Immune Netw. 2016 Jun; 16(3):189-94.
9. Karki P, Johnson J, Son DS, Aschner M, Lee E. Transcriptional Regulation of Human Transforming Growth Factor-a in Astrocytes. Mol Neurobiol. 2017 Mar; 54(2):964-976.
10. Wilson AJ, Fadare O, Beeghly-Fadiel A, Son DS, Liu Q, Zhao S, Saskowski J, Uddin MJ, Daniel C, Crews B, Lehmann BD, Pietenpol JA, Crispens MA, Marnett LJ, Khabele D. Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer. Oncotarget. 2015 Aug 28; 6(25):21353-68.
11. Karki P, Kim C, Smith K, Son DS, Aschner M, Lee E. Transcriptional Regulation of the Astrocytic Excitatory Amino Acid Transporter 1 (EAAT1) via NF-?B and Yin Yang 1 (YY1). J Biol Chem. 2015 Sep 25; 290(39):23725-37.
12. Khabele D, Kabir SM, Dong Y, Lee E, Rice VM, Son DS. Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF. J Cancer. 2014; 5(8):670-8.
13. Karki P, Webb A, Zerguine A, Choi J, Son DS, Lee E. Mechanism of raloxifene-induced upregulation of glutamate transporters in rat primary astrocytes. Glia. 2014 Aug; 62(8):1270-83.
14. Kim B, Wang S, Lee JM, Jeong Y, Ahn T, Son DS, Park HW, Yoo HS, Song YJ, Lee E, Oh YM, Lee SB, Choi J, Murray JC, Zhou Y, Song PH, Kim KA, Weiner LM. Synthetic lethal screening reveals FGFR as one of the combinatorial targets to overcome resistance to Met-targeted therapy. Oncogene. 2015 Feb 26; 34(9):1083-93.
15. Kabir SM, Lee ES, Son DS. Chemokine network during adipogenesis in 3T3-L1 cells: Differential response between growth and proinflammatory factor in preadipocytes vs. adipocytes. Adipocyte. 2014 Apr 01; 3(2):97-106.
16. Karki P, Webb A, Smith K, Johnson J, Lee K, Son DS, Aschner M, Lee E. Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes. Mol Cell Biol. 2014 Apr; 34(7):1280-9.
17. Dong YL, Kabir SM, Lee ES, Son DS. CXCR2-driven ovarian cancer progression involves upregulation of proinflammatory chemokines by potentiating NF-?B activation via EGFR-transactivated Akt signaling. PLoS One. 2013; 8(12):e83789.
18. Cho M, Kabir SM, Dong Y, Lee E, Rice VM, Khabele D, Son DS. Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian Cancer Cells. J Cancer. 2013; 4(8):671-8.
19. Karki P, Webb A, Smith K, Lee K, Son DS, Aschner M, Lee E. cAMP response element-binding protein (CREB) and nuclear factor ?B mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes. J Biol Chem. 2013 Oct 04; 288(40):28975-86.
20. Son DS, Kabir SM, Dong Y, Lee E, Adunyah SE. Characteristics of chemokine signatures elicited by EGF and TNF in ovarian cancer cells. J Inflamm (Lond). 2013 Jun 25; 10(1):25.
21. Son DS, Kabir SM, Dong YL, Lee E, Adunyah SE. Inhibitory effect of tumor suppressor p53 on proinflammatory chemokine expression in ovarian cancer cells by reducing proteasomal degradation of I?B. PLoS One. 2012; 7(12):e51116.
22. Lee E, Sidoryk-Wêgrzynowicz M, Wang N, Webb A, Son DS, Lee K, Aschner M. GPR30 regulates glutamate transporter GLT-1 expression in rat primary astrocytes. J Biol Chem. 2012 Aug 03; 287(32):26817-28.
23. Lee E, Sidoryk-Wegrzynowicz M, Yin Z, Webb A, Son DS, Aschner M. Transforming growth factor-a mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia. 2012 Jul; 60(7):1024-36.
24. Son DS, Wilson AJ, Parl AK, Khabele D. The effects of the histone deacetylase inhibitor romidepsin (FK228) are enhanced by aspirin (ASA) in COX-1 positive ovarian cancer cells through augmentation of p21. Cancer Biol Ther. 2010 Jun 01; 9(11):928-35.
25. Son DS, Terranova PF, Roby KF. Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform. Endocrinology. 2010 Jul; 151(7):3407-19.
26. Lyshchik A, Hobbs SB, Fleischer AC, Khabele D, Son DS, Gore JC, Price RR. Ovarian volume measurements in mice with high-resolution ultrasonography. J Ultrasound Med. 2007 Oct; 26(10):1419-25.
27. Son DS, Parl AK, Rice VM, Khabele D. Keratinocyte chemoattractant (KC)/human growth-regulated oncogene (GRO) chemokines and pro-inflammatory chemokine networks in mouse and human ovarian epithelial cancer cells. Cancer Biol Ther. 2007 Aug; 6(8):1302-12.
28. Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM, Rice VM. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer Biol Ther. 2007 May; 6(5):795-801.
29. Son DS, Roby KF. Interleukin-1alpha-induced chemokines in mouse granulosa cells: impact on keratinocyte chemoattractant chemokine, a CXC subfamily. Mol Endocrinol. 2006 Nov; 20(11):2999-3013.
30. Kim JS, Jin DI, Lee JH, Son DS, Lee SH, Yi YJ, Park CS. Effects of teat number on litter size in gilts. Anim Reprod Sci. 2005 Nov; 90(1-2):111-6.
31. Roby KF, Son DS, Taylor CC, Montgomery-Rice V, Kirchoff J, Tang S, Terranova PF. Alterations in reproductive function in SRC tyrosine kinase knockout mice. Endocrine. 2005 Mar; 26(2):169-76.
32. Son DS, Roby KF, Terranova PF. Tumor necrosis factor-alpha induces serum amyloid A3 in mouse granulosa cells. Endocrinology. 2004 May; 145(5):2245-52.
33. Williams SR, Son DS, Terranova PF. Protein kinase C delta is activated in mouse ovarian surface epithelial cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicology. 2004 Jan 15; 195(1):1-17.
34. Son DS, Arai KY, Roby KF, Terranova PF. Tumor necrosis factor alpha (TNF) increases granulosa cell proliferation: dependence on c-Jun and TNF receptor type 1. Endocrinology. 2004 Mar; 145(3):1218-26.
35. Son DS, Roby KF, Rozman KK, Terranova PF. Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line. Toxicology. 2002 Jul 15; 176(3):229-43.
36. Son DS, Rozman KK. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces plasminogen activator inhibitor-1 through an aryl hydrocarbon receptor-mediated pathway in mouse hepatoma cell lines. Arch Toxicol. 2002 Jul; 76(7):404-13.
37. Mizuyachi K, Son DS, Rozman KK, Terranova PF. Alteration in ovarian gene expression in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin: reduction of cyclooxygenase-2 in the blockage of ovulation. Reprod Toxicol. 2002 May-Jun; 16(3):299-307.
38. Petroff BK, Gao X, Ohshima K, Shi F, Son DS, Roby KF, Rozman KK, Watanabe G, Taya K, Terranova PF. Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on serum inhibin concentrations and inhibin immunostaining during follicular development in female Sprague-Dawley rats. Reprod Toxicol. 2002 Mar-Apr; 16(2):97-105.
39. Kuroha M, Son DS, Shimoda M. Effects of altered plasma alpha-1-acid glycoprotein levels on pharmacokinetics of some basic antibiotics in pigs: simulation analysis. J Vet Pharmacol Ther. 2001 Dec; 24(6):423-31.
40. Kim IH, Son DS, Yeon SH, Choi SH, Park SB, Ryu IS, Suh GH, Lee DW, Lee CS, Lee HJ, Yoon JT. Effect of dominant follicle removal before superstimulation on follicular growth, ovulation and embryo production in Holstein cows. Theriogenology. 2001 Mar 01; 55(4):937-45.
41. Koo DB, Kang YK, Choi YH, Park JS, Han SK, Park IY, Kim SU, Lee KK, Son DS, Chang WK, Han YM. In vitro development of reconstructed porcine oocytes after somatic cell nuclear transfer. Biol Reprod. 2000 Oct; 63(4):986-92.
42. Son DS, Ikenoue N, Tagawa Y, Shimoda M, Kokue E. Non-linear pharmacokinetics of ofloxacin after a single intravenous bolus dose in pigs. J Vet Pharmacol Ther. 2000 Oct; 23(5):311-5.
43. Roby KF, Son DS, Terranova PF. Alterations of events related to ovarian function in tumor necrosis factor receptor type I knockout mice. Biol Reprod. 1999 Dec; 61(6):1616-21.
44. Son DS, Ushinohama K, Gao X, Taylor CC, Roby KF, Rozman KK, Terranova PF. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) blocks ovulation by a direct action on the ovary without alteration of ovarian steroidogenesis: lack of a direct effect on ovarian granulosa and thecal-interstitial cell steroidogenesis in vitro. Reprod Toxicol. 1999 Nov-Dec; 13(6):521-30.
45. Gao X, Son DS, Terranova PF, Rozman KK. Toxic equivalency factors of polychlorinated dibenzo-p-dioxins in an ovulation model: validation of the toxic equivalency concept for one aspect of endocrine disruption. Toxicol Appl Pharmacol. 1999 Jun 01; 157(2):107-16.
46. Kim IH, Son DS, Lee HJ, Yang BC, Lee DW, Suh GH, Lee KW, Jung SC. Bacteria in semen used for IVF affect embryo viability but can be removed by stripping cumulus cells by vortexing. Theriogenology. 1998 Jul 15; 50(2):293-300.
47. Son DS, Osabe M, Shimoda M, Kokue E. Contribution of alpha 1-acid glycoprotein to species difference in lincosamides-plasma protein binding kinetics. J Vet Pharmacol Ther. 1998 Feb; 21(1):34-40.
48. Shimoda M, Okamoto K, Sikazwe G, Fujii C, Son DS. Deacetylation as a determinant of sulphonamide pharmacokinetics in pigs. Vet Q. 1997 Nov; 19(4):186-91.
49. Son DS, Hariya S, Shimoda M, Kokue E. Contribution of alpha 1-acid glycoprotein to plasma protein binding of some basic antimicrobials in pigs. J Vet Pharmacol Ther. 1996 Jun; 19(3):176-83.
50. Son DS, Shimoda M, Kokve E. Implication of altered levels of plasma alpha(1)-acid glycoprotein and its derived sialic acid on plasma protein binding of trimethoprim in pigs in physiological and pathological states. Vet Q. 1996 Mar; 18(1):10-3.
51. Kinoshita T, Son DS, Shimoda M, Kokue E. Impact of age-related alteration of plasma alpha 1-acid glycoprotein concentration on erythromycin pharmacokinetics in pigs. Am J Vet Res. 1995 Mar; 56(3):362-5.
52. Tagawa Y, Kokue E, Shimoda M, Son DS. Alpha 1-acid glycoprotein-binding as a factor in age-related changes in the pharmacokinetics of trimethoprim in piglets. Vet Q. 1994 Mar; 16(1):13-7.

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Ovarian Neoplasms
NF-kappa B
Chemokines
Granulosa Cells
Tumor Necrosis Factor-alpha
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