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Wei-Kung Wang
Title Associate Professor
Faculty Rank
Degree M.D., Sc.D.
Institution University of Hawaii
Department Department of Tropical Medicine, Medical Microbiology and Pharmacology
Clusters Infectious and Immunological Diseases
John A. Burns School of Medicine
651 Ilalo Street, BSB225E
City Honolulu
State HI
Postal Code 96813
Telephone 808 692-1667
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  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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2018Mature virus-like particles as a new strategy for dengue virus vaccines5R01AI110769-05
2018Serodiagnostic tests to distinguish Zika virus from other flaviviruses1R21AI135292-01A1
2017Mature virus-like particles as a new strategy for dengue virus vaccines5R01AI110769-04
2016Mature virus-like particles as a new strategy for dengue virus vaccines5R01AI110769-03
2015Mature virus-like particles as a new strategy for dengue virus vaccines5R01AI110769-02
2014Mature virus-like particles as a new strategy for dengue virus vaccines1R01AI110769-01

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1. Wang WK, Gubler DJ. Potential Point-of-Care Testing for Dengue Virus in the Field. J Clin Microbiol. 2018 May; 56(5).
2. Tsai WY, Youn HH, Brites C, Tsai JJ, Tyson J, Pedroso C, Drexler JF, Stone M, Simmons G, Busch MP, Lanteri M, Stramer SL, Balmaseda A, Harris E, Wang WK. Distinguishing Secondary Dengue Virus Infection From Zika Virus Infection With Previous Dengue by a Combination of 3 Simple Serological Tests. Clin Infect Dis. 2017 Nov 13; 65(11):1829-1836.
3. Tsai WY, Lin HE, Wang WK. Complexity of Human Antibody Response to Dengue Virus: Implication for Vaccine Development. Front Microbiol. 2017; 8:1372.
4. Hsieh SC, Wu YC, Zou G, Nerurkar VR, Shi PY, Wang WK. Highly conserved residues in the helical domain of dengue virus type 1 precursor membrane protein are involved in assembly, precursor membrane (prM) protein cleavage, and entry. J Biol Chem. 2014 Nov 28; 289(48):33149-60.
5. Hsieh SC, Tsai WY, Nerurkar VR, Wang WK. Characterization of the ectodomain of the envelope protein of dengue virus type 4: expression, membrane association, secretion and particle formation in the absence of precursor membrane protein. PLoS One. 2014; 9(6):e100641.
6. Lai CY, Williams KL, Wu YC, Knight S, Balmaseda A, Harris E, Wang WK. Analysis of cross-reactive antibodies recognizing the fusion loop of envelope protein and correlation with neutralizing antibody titers in Nicaraguan dengue cases. PLoS Negl Trop Dis. 2013; 7(9):e2451.
7. Tsai WY, Lai CY, Wu YC, Lin HE, Edwards C, Jumnainsong A, Kliks S, Halstead S, Mongkolsapaya J, Screaton GR, Wang WK. High-avidity and potently neutralizing cross-reactive human monoclonal antibodies derived from secondary dengue virus infection. J Virol. 2013 Dec; 87(23):12562-75.
8. Tsai WY, Hsieh SC, Lai CY, Lin HE, Nerurkar VR, Wang WK. C-terminal helical domains of dengue virus type 4 E protein affect the expression/stability of prM protein and conformation of prM and E proteins. PLoS One. 2012; 7(12):e52600.
9. Rao KV, Beri GD, Wang WW. Trimming of a migrated metal stent for malignant colonic stricture using argon plasma coagulation. World J Gastrointest Endosc. 2010 Feb 16; 2(2):75-6.
10. Wang WK, Chen HL, Yang CF, Hsieh SC, Juan CC, Chang SM, Yu CC, Lin LH, Huang JH, King CC. Slower rates of clearance of viral load and virus-containing immune complexes in patients with dengue hemorrhagic fever. Clin Infect Dis. 2006 Oct 15; 43(8):1023-30.
11. Wang WK, Chao DY, Lin SR, King CC, Chang SC. Concurrent infections by two dengue virus serotypes among dengue patients in Taiwan. J Microbiol Immunol Infect. 2003 Jun; 36(2):89-95.
12. Wang WK, Chao DY, Kao CL, Wu HC, Liu YC, Li CM, Lin SC, Ho ST, Huang JH, King CC. High levels of plasma dengue viral load during defervescence in patients with dengue hemorrhagic fever: implications for pathogenesis. Virology. 2003 Jan 20; 305(2):330-8.
13. Wang WK, Sung TL, Tsai YC, Kao CL, Chang SM, King CC. Detection of dengue virus replication in peripheral blood mononuclear cells from dengue virus type 2-infected patients by a reverse transcription-real-time PCR assay. J Clin Microbiol. 2002 Dec; 40(12):4472-8.
14. Wang WK, Sung TL, Lee CN, Lin TY, King CC. Sequence diversity of the capsid gene and the nonstructural gene NS2B of dengue-3 virus in vivo. Virology. 2002 Nov 10; 303(1):181-91.
15. Wang WK, Lin SR, Lee CM, King CC, Chang SC. Dengue type 3 virus in plasma is a population of closely related genomes: quasispecies. J Virol. 2002 May; 76(9):4662-5.
16. Wang WK, Lee CN, Kao CL, Lin YL, King CC. Quantitative competitive reverse transcription-PCR for quantification of dengue virus RNA. J Clin Microbiol. 2000 Sep; 38(9):3306-10.
17. Wang W, Liu LQ, Higuchi CM, Chen H. Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells. Biochem Pharmacol. 1998 Jul 15; 56(2):189-95.
18. Wang W. Radioimmunoassay determination of formononetin in murine plasma and mammary glandular tissue. Proc Soc Exp Biol Med. 1998 Mar; 217(3):281-7.
19. Wang W, Liu LQ, Higuchi CM. Mucosal polyamine measurements and colorectal cancer risk. J Cell Biochem. 1996 Nov 01; 63(2):252-7.
20. Wang W, Kucuk O, Franke AA, Liu LQ, Custer LJ, Higuchi CM. Reproducibility of erythrocyte polyamine measurements and correlation with plasma micronutrients in an antioxidant vitamin intervention study. J Cell Biochem. 1996 Jul; 62(1):19-26.
21. Wang W, Higuchi CM. Induction of NAD(P)H:quinone reductase by vitamins A, E and C in Colo205 colon cancer cells. Cancer Lett. 1995 Nov 27; 98(1):63-9.
22. Higuchi CM, Wang W. Comodulation of cellular polyamines and proliferation: biomarker application to colorectal mucosa. J Cell Biochem. 1995 Feb; 57(2):256-61.

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