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Nawal M. Boukli
Title Director of Biomedical Proteomics Facility
Faculty Rank Full Professor
Degree Ph.D.
Institution Universidad Central Del Caribe
Department Microbiology and Immunology
Clusters Cancer
Department of Microbiology and Immunology
Universidad Central del Caribe
P.O. Box 60327, PR, USA
City Bayamon
State PR
Postal Code 00960
Telephone 787-798-3001 ext. 2080
Fax 787-740-4300
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Awards and Honors icon

2005 San Juan Invited speaker, Addiction Technology Transfer Center Symposium. “Effect of the stress on the immu
2005 SANOFI-Aventis Invited speaker, high-throughput Proteomics: Protein Expression and Purification in the Postgenomi
2005 Natural Science Department, University of Puerto Rico, Aguadilla Keynote speaker: Fifth Student Scientific Research Symposium. “Proteomics in the Medical Field”
2006 National Hispanic Science Network on Drug Abuse 6th Annual Conference Presenter/Panel discussion member, Spoke about: “How to Develop Your Research Question”. Grant Wri
2009 Florida International University Invited speaker at the Institute of NeuroImmune Pharmacology
2018 Association of the Southeastern Association of Shared Resources (SEASR)/ABRF) Executive Board Member

Narrative icon

  Dr. Boukli is a Professor in the department of microbiology and immunology and is the Director of the Biomedical Proteomics Facility at the Universidad Central del Caribe, School of Medicine, PR, USA. Dr. Boukli got her Doctoral degree in Molecular Biology from the University of Geneva, Switzerland, where she worked in early molecular signaling events such as the type three secretion pathway in Rhyzobium bacteria. Dr. Boukli did her postdoctoral fellowship at the University of Missouri where she gained more expertise in proteomics technology. She then joined the Universidad Central Del Caribe where she organized a high-throughput Proteomic Core Facility. Dr. Boukli’s research uses the latest technologies, including quantitative proteomics multiplexing with isobaric tags approaches and molecular and flow cytometric analyses for the detection of biomarkers and molecular signatures in HIV, drug and alcohol of abuse, cancer and multiple sclerosis. Dr. Boukli has numerous peer-review articles and NIH funded grants on these and related topics. Dr. Boukli is also interested in how endoplasmic reticulum stress responses and cell fate decision can regulate the network of apoptotic and survival signal events in different cells and systems and the anti-cancer and anti-HIV mechanistic effects of natural compounds for cancer and HIV treatment as some of her publications demonstrate (Boukli et al, 2010, Boukli et al, 2011, Boukli et al, 2012, Rivera et al, and Boukli, 2016, Lopez et al, and Boukli, 2017, Rodriguez et al, and Boukli, 2018), see publications below).
In addition to her research pursuits, Dr. Boukli has been active in training young investigators, both individually (as a mentor and proteomics facility resource, post-doctoral fellows, medical students, Master and PhD trainees) and in the classroom (where she has developed a proteomics graduate-level course and several workshops on proteomics in clinical research). 

Language Skills:

• French (native)
• Arabic (native)
• English (Fluent, speaking, Fluent reading, Fluent writing)
• Spanish (Fluent, speaking, Fluent reading, Fluent writing)
• Italian (Fluent, speaking, Fluent reading, intermediate writing)

Publications icon

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1. López SN, Rodríguez-Valentín M, Rivera M, Rodríguez M, Babu M, Cubano LA, Xiong H, Wang G, Kucheryavykh L, Boukli NM. HIV-1 Gp120 clade B/C induces a GRP78 driven cytoprotective mechanism in astrocytoma. Oncotarget. 2017 Sep 15; 8(40):68415-68438.
2. Rivera M, Ramos Y, Rodríguez-Valentín M, López-Acevedo S, Cubano LA, Zou J, Zhang Q, Wang G, Boukli NM. Targeting multiple pro-apoptotic signaling pathways with curcumin in prostate cancer cells. PLoS One. 2017; 12(6):e0179587.
3. Sepúlveda-Torres LDC, Rishishwar L, Rogers ML, Ríos-Olivares E, Boukli N, Jordan IK, Cubano LA. A decade of viral mutations and associated drug resistance in a population of HIV-1+ Puerto Ricans: 2002-2011. PLoS One. 2017; 12(5):e0177452.
4. Burton LJ, Rivera M, Hawsawi O, Zou J, Hudson T, Wang G, Zhang Q, Cubano L, Boukli N, Odero-Marah V. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. PLoS One. 2016; 11(10):e0164115.
5. Ricaurte M, Schizas NV, Ciborowski P, Boukli NM. Proteomic analysis of bleached and unbleached Acropora palmata, a threatened coral species of the Caribbean. Mar Pollut Bull. 2016 Jun 15; 107(1):224-232.
6. Soulié C, Fofana DB, Boukli N, Sayon S, Lambert-Niclot S, Wirden M, Simon A, Katlama C, Calvez V, Girard PM, Marcelin AG, Morand-Joubert L. Performance of genotypic algorithms for predicting tropism of HIV-1CRF02_AG subtype. J Clin Virol. 2016 Mar; 76:51-4.
7. Berríos VO, Boukli NM, Rodriguez JW, Negraes PD, Schwindt TT, Trujillo CA, Oliveira SL, Cubano LA, Ferchmin PA, Eterovic VA, Ulrich H, Martins AH. Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation. Neurochem Res. 2015 Oct; 40(10):2091-101.
8. Yang J, Hu D, Xia J, Liu J, Zhang G, Gendelman HE, Boukli NM, Xiong H. Enhancement of NMDA receptor-mediated excitatory postsynaptic currents by gp120-treated macrophages: implications for HIV-1-associated neuropathology. J Neuroimmune Pharmacol. 2013 Sep; 8(4):921-33.
9. Miranda MT, Suárez E, Abbas M, Chinea A, Tosado R, Mejías IA, Boukli N, Dunston GM. HLA class I & II alleles in multiple sclerosis patients from Puerto Rico. Bol Asoc Med P R. 2013; 105(1):18-23.
10. Boukli NM, Shetty V, Cubano L, Ricaurte M, Coelho-Dos-Reis J, Nickens Z, Shah P, Talal AH, Philip R, Jain P. Unique and differential protein signatures within the mononuclear cells of HIV-1 and HCV mono-infected and co-infected patients. Clin Proteomics. 2012 Sep 07; 9(1):11.
11. Sepúlveda-Torres Ldel C, De La Rosa A, Cumba L, Boukli N, Ríos-Olivares E, Cubano LA. Prevalence of Drug Resistance and Associated Mutations in a Population of HIV-1(+) Puerto Ricans: 2006-2010. AIDS Res Treat. 2012; 2012:934041.
12. Mazzio EA, Boukli N, Rivera N, Soliman KF. Pericellular pH homeostasis is a primary function of the Warburg effect: inversion of metabolic systems to control lactate steady state in tumor cells. Cancer Sci. 2012 Mar; 103(3):422-32.
13. Kurapati KR, Samikkannu T, Kadiyala DB, Zainulabedin SM, Gandhi N, Sathaye SS, Indap MA, Boukli N, Rodriguez JW, Nair MP. Combinatorial cytotoxic effects of Curcuma longa and Zingiber officinale on the PC-3M prostate cancer cell line. J Basic Clin Physiol Pharmacol. 2012; 23(4):139-46.
14. Boukli NM, Delgado B, Ricaurte M, Espino AM. Fasciola hepatica and Schistosoma mansoni: identification of common proteins by comparative proteomic analysis. J Parasitol. 2011 Oct; 97(5):852-61.
15. Boukli NM, Saiyed ZM, Ricaurte M, Rodriguez JW, Ríos Olivares E, Cubano LA, Nair MP. Implications of ER stress, the unfolded protein response, and pro- and anti-apoptotic protein fingerprints in human monocyte-derived dendritic cells treated with alcohol. Alcohol Clin Exp Res. 2010 Dec; 34(12):2081-8.
16. Cubano LA, Cumba L, del Sepúlveda-Torres LC, Boukli N, Ríos-Olivares E. Prevalence of drug resistance and associated mutations in a population of Hiv-1+ Puerto Ricans in 2005. Bol Asoc Med P R. 2010 Jul-Sep; 102(3):13-7.
17. Nair MP, Saiyed ZM, Nair N, Gandhi NH, Rodriguez JW, Boukli N, Provencio-Vasquez E, Malow RM, Miguez-Burbano MJ. Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells. J Neuroimmune Pharmacol. 2009 Mar; 4(1):129-39.
18. Cubano LA, Sepúlveda-Torres Ldel C, Sosa G, Boukli N, Robles R, Rodriguez JW, Guzmán L, Ríos-Olivares E. Prevalence of drug resistance and associated mutations in HIV-positive Puerto Ricans: sex variations. Ethn Dis. 2008; 18(2 Suppl 2):S2-132-6.
19. Rodríguez JW, Pagan NO, Ocasio MC, Ríos Z, Cubano LA, Boukli NM, Otero M, Hunter R, Nair MP, Rios-Olivares E. Induction of a Soluble Anti-HIV-1 factor (s) with IFN-?, IL-10, and ß-Chemokine Modulating Activity by an Influenza-Bacterial Polyantigenic Mixture. Am J Infect Dis. 2007; 3(4).
20. Ríos-Olivares E, Vilá LM, Reyes JC, Rodríguez JW, Colón JH, Pagán NO, Marrero A, Ríos-Orraca ZM, Boukli NM, Shapshak P, Robles RR. Impaired cytokine production and suppressed lymphocyte proliferation activity in HCV-infected cocaine and heroin ("speedball") users. Drug Alcohol Depend. 2006 Dec 01; 85(3):236-43.
21. Boukli NM, Sunderasan E, Bartsev A, Hochstrasser D, Perret X, Bjourson AJ, Krause A, Broughton WJ. Early legume responses to inoculation with Rhizobium sp. NGR234. J Plant Physiol. 2007 Jun; 164(6):794-806.
22. Skorpil P, Saad MM, Boukli NM, Kobayashi H, Ares-Orpel F, Broughton WJ, Deakin WJ. NopP, a phosphorylated effector of Rhizobium sp. strain NGR234, is a major determinant of nodulation of the tropical legumes Flemingia congesta and Tephrosia vogelii. Mol Microbiol. 2005 Sep; 57(5):1304-17.
23. Launay O, Roudière L, Boukli N, Dupont B, Prévoteau du Clary F, Patey O, David F, Lortholary O, Devidas A, Piketty C, Rey E, Urbinelli R, Allaert FA, Tréluyer JM, Caumes E. Assessment of cetirizine, an antihistamine, to prevent cutaneous reactions to nevirapine therapy: results of the viramune-zyrtec double-blind, placebo-controlled trial. Clin Infect Dis. 2004 Apr 15; 38(8):e66-72.
24. Bartsev AV, Deakin WJ, Boukli NM, McAlvin CB, Stacey G, Malnoë P, Broughton WJ, Staehelin C. NopL, an effector protein of Rhizobium sp. NGR234, thwarts activation of plant defense reactions. Plant Physiol. 2004 Feb; 134(2):871-9.
25. Bartsev AV, Boukli NM, Deakin WJ, Staehelin C, Broughton WJ. Purification and phosphorylation of the effector protein NopL from Rhizobium sp. NGR234. FEBS Lett. 2003 Nov 20; 554(3):271-4.
26. Meynard JL, Guiguet M, Rachline A, Boukli N, Bollens D, Gentil C, Frottier J, Morand-Joubert L. [Predictive factors of virologic response to antiretroviral treatment with a protease inhibitor in HIV infection]. Presse Med. 2001 Jan 13; 30(1):5-10.
27. Salmon-Céron D, Mazeron MC, Chaput S, Boukli N, Senechal B, Houhou N, Katlama C, Matheron S, Fillet AM, Gozlan J, Leport C, Jeantils V, Freymuth F, Costagliola D. Plasma cytomegalovirus DNA, pp65 antigenaemia and a low CD4 cell count remain risk factors for cytomegalovirus disease in patients receiving highly active antiretroviral therapy. AIDS. 2000 May 26; 14(8):1041-9.

Abstracts icon


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1. Lariguet, P., Pankhurst, C.E., Porch, T., Silue, S., Boukli, N.M., Ishitani, M., Rao, I.M., Beebe, S., Triplett, E.W., Baudoin, J.P., Blair, M.W., and Broughton, W.J. . “Tilling Beans for Changes in Nodule and Seed Development as well as Tolerance to Aluminium”. In Proc. Phaseomics IV. 2005; 252:175-179.

Non-Print Materials icon


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1. Rao, K., Boukli, N., Samikkannu, T., Cubano, L., Dakshayani, K, Nair, M. . Profiling in PC-3M Prostate Cancer Cell Line and Cytotoxic Effects of Cucurma Longa. 2011.

Original Articles icon


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1. Rodríguez, J.W., Rodríguez, L.A., Font, G., Nieves, K., Cubano, L.A., Boukli, N., Otero, M., Hunter, R., Nair, M.P., and Ríos-Olivares, E. . Co-Expression of Apoptosis-Related Molecules on Activated CD8+CD38+ T-Cells is Associated with HIV-1 Disease Progression. American Journal of Infectious Disease. 2007; 4(3):208-216.
2. Boukli, N. M., Deakin, J.W., Kambara, K., Kobayashi, H., Marie, C., Perret, X., Le Quéré, A., Reuhs, B., Saad, M., Schumpp, O., Skorpil, P., Staehelin, C., Streit, W., and Broughton, W.J. . Springer Verlag, Berlin. “Rhizobial Control of Host-specificity”. Proceedings of the 14th International Congress on Nitrogen Fixation". 2005; 217-218.
3. Boukli, N.M., W.J. Deakin, K. Kambara, H. Kobayashi, C. Marie, X. Perret, A. Le Quéré, B. Reuhs*, M. Saad, O. Schumpp, P. Skorpil, C. Staehelin, W. Streit, & W.J. Broughton. . "Cell and Molecular Biology of Plant Root-Hairs". Springer-Verlag, Tokyo. 2004; 79-91.
4. Naturally Derived Anti-HIV Polysaccharide Peptide (PSP) Triggers a Toll-Like Receptor 4-Dependent Antiviral Immune Response.

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