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Scott Kuwada
Title Professor of Medicine, Chief, Div. of Gastroenterology
Faculty Rank Professor
Degree MD
Institution University of Hawaii
Department Medicine
Clusters Cancer
651 Ilalo St
City Honolulu
State HI
Postal Code 96813
Telephone 808-692-1550
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1. Samadder NJ, Kuwada SK, Boucher KM, Byrne K, Kanth P, Samowitz W, Jones D, Tavtigian SV, Westover M, Berry T, Jasperson K, Pappas L, Smith L, Sample D, Burt RW, Neklason DW. Association of Sulindac and Erlotinib vs Placebo With Colorectal Neoplasia in Familial Adenomatous Polyposis: Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol. 2018 05 01; 4(5):671-677.
2. Samadder NJ, Neklason DW, Boucher KM, Byrne KR, Kanth P, Samowitz W, Jones D, Tavtigian SV, Done MW, Berry T, Jasperson K, Pappas L, Smith L, Sample D, Davis R, Topham MK, Lynch P, Strait E, McKinnon W, Burt RW, Kuwada SK. Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial. JAMA. 2016 Mar 22-29; 315(12):1266-75.
3. Kaalekahi JM, Gandhi KR, Chen JJ, Kuwada SK. Colonoscopy Screening among Native Hawaiians at Queen''s Medical Center between August 2011 and January 2013. Hawaii J Med Public Health. 2016 Jan; 75(1):13-7.
4. Shen Y, Zificsak CA, Shea JE, Lao X, Bollt O, Li X, Lisko JG, Theroff JP, Scaife CL, Ator MA, Ruggeri BA, Dorsey BD, Kuwada SK. Design, synthesis, and biological evaluation of sulfonyl acrylonitriles as novel inhibitors of cancer metastasis and spread. J Med Chem. 2015 Feb 12; 58(3):1140-58.
5. Xu C, Li X, Topham MK, Kuwada SK. Regulation of sonic hedgehog expression by integrin ß1 and epidermal growth factor receptor in intestinal epithelium. IUBMB Life. 2014 Oct; 66(10):694-703.
6. Lopez KT, Kuwada SK, Wong LL. Consequences of needle tract seeding of hepatocellular cancer after liver transplant. Clin Transplant. 2013 Jul-Aug; 27(4):E400-6.
7. Gammon A, Jasperson K, Pilarski R, Prior T, Kuwada S. PTEN mosaicism with features of Cowden syndrome. Clin Genet. 2013 Dec; 84(6):593-5.
8. Li X, Kuang J, Shen Y, Majer MM, Nelson CC, Parsawar K, Heichman KA, Kuwada SK. The atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cells. J Biol Chem. 2012 Jun 29; 287(27):23171-83.
9. Zificsak CA, Shen Y, Lisko JG, Theroff JP, Lao X, Bollt O, Li X, Dorsey BD, Kuwada SK. Synthesis and biological evaluation of sulfonyl acrylonitriles as novel inhibitors to peritoneal carcinomatosis. Bioorg Med Chem Lett. 2012 Mar 01; 22(5):1850-3.
10. Kuwada SK, Burt R. A rationale for mTOR inhibitors as chemoprevention agents in Peutz-Jeghers syndrome. Fam Cancer. 2011 Sep; 10(3):469-72.
11. Shen Y, Herde R, Doxey BW, Xu C, Gray PD, Kuwada SK. Pharmacologic downregulation of c-FLIP(L) restores juxtacrine death receptor-mediated apoptosis in cancer cells in a peritoneal carcinomatosis model. Int J Cancer. 2012 Apr 01; 130(7):1494-503.
12. Neklason DW, Tuohy TM, Stevens J, Otterud B, Baird L, Kerber RA, Samowitz WS, Kuwada SK, Leppert MF, Burt RW. Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer. J Med Genet. 2010 Oct; 47(10):692-9.
13. Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Mol Cell Biol. 2010 Mar; 30(6):1341-56.
14. Wang SJ, Furusho M, D''Sa C, Kuwada S, Conti L, Morest DK, Bansal R. Inactivation of fibroblast growth factor receptor signaling in myelinating glial cells results in significant loss of adult spiral ganglion neurons accompanied by age-related hearing impairment. J Neurosci Res. 2009 Nov 15; 87(15):3428-37.
15. Kuwada SK. Stopping cancer cells in their tracks... Hawaii Med J. 2009 Nov; 68(10):259-60.
16. LaBarbera DV, Modzelewska K, Glazar AI, Gray PD, Kaur M, Liu T, Grossman D, Harper MK, Kuwada SK, Moghal N, Ireland CM. The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells. Anticancer Drugs. 2009 Jul; 20(6):425-36.
17. Neklason DW, Thorpe BL, Ferrandez A, Tumbapura A, Boucher K, Garibotti G, Kerber RA, Solomon CH, Samowitz WS, Fang JC, Mineau GP, Leppert MF, Burt RW, Kuwada SK. Colonic adenoma risk in familial colorectal cancer--a study of six extended kindreds. Am J Gastroenterol. 2008 Oct; 103(10):2577-84.
18. Mackenzie SH, Go M, Chadwick B, Thomas K, Fang J, Kuwada S, Lamphier S, Hilden K, Peterson K. Eosinophilic oesophagitis in patients presenting with dysphagia--a prospective analysis. Aliment Pharmacol Ther. 2008 Nov 01; 28(9):1140-6.
19. Majer M, Akerley W, Kuwada SK. Oncologists'' current opinion on the treatment of colon carcinoma. Anticancer Agents Med Chem. 2007 Sep; 7(5):492-503.
20. Mackenzie SH, Fang JC, Kuwada SK. Severe upper-GI bleeding in a patient with PEG tube placement by the radiologic push method. Gastrointest Endosc. 2007 May; 65(6):935-7.
21. Kuwada SK. Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody. Curr Opin Mol Ther. 2007 Feb; 9(1):92-8.
22. Jones RG, Li X, Gray PD, Kuang J, Clayton F, Samowitz WS, Madison BB, Gumucio DL, Kuwada SK. Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol. 2006 Nov 06; 175(3):505-14.
23. Ferrández A, Pho L, Solomon C, Samowitz WS, Kuwada SK, Knecht TP, Gilfeather M, Burt RW. An evidence-based, multidisciplinary approach to the clinical considerations, management, and surveillance of adrenal lesions in familial adenomatous polyposis: report of three cases. Dis Colon Rectum. 2006 Nov; 49(11):1781-90.
24. Maul JS, Warner NR, Kuwada SK, Burt RW, Cannon-Albright LA. Extracolonic cancers associated with hereditary nonpolyposis colorectal cancer in the Utah Population Database. Am J Gastroenterol. 2006 Jul; 101(7):1591-6.
25. Arber N, Kuwada S, Leshno M, Sjodahl R, Hultcrantz R, Rex D. Sporadic adenomatous polyp regression with exisulind is effective but toxic: a randomised, double blind, placebo controlled, dose-response study. Gut. 2006 Mar; 55(3):367-73.
26. Alonso-Coello P, Wong RF, Kuwada SK. Other strategies for evaluating rectal bleeding in younger patients. J Fam Pract. 2005 Aug; 54(8):688-9; author reply 689.
27. Doxey BW, Kuwada SK, Burt RW. Inherited polyposis syndromes: molecular mechanisms, clinicopathology, and genetic testing. Clin Gastroenterol Hepatol. 2005 Jul; 3(7):633-41.
28. Kuwada SK, Kuang J, Li X. Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells. J Biol Chem. 2005 May 13; 280(19):19027-35.
29. Wong RF, Khosla R, Moore JH, Kuwada SK. Consider colonoscopy for young patients with hematochezia. J Fam Pract. 2004 Nov; 53(11):879-84.
30. Burt RW, Leppert MF, Slattery ML, Samowitz WS, Spirio LN, Kerber RA, Kuwada SK, Neklason DW, Disario JA, Lyon E, Hughes JP, Chey WY, White RL. Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. Gastroenterology. 2004 Aug; 127(2):444-51.
31. Kuwada SK, Scaife CL, Kuang J, Li X, Wong RF, Florell SR, Coffey RJ, Gray PD. Effects of trastuzumab on epidermal growth factor receptor-dependent and -independent human colon cancer cells. Int J Cancer. 2004 Mar 20; 109(2):291-301.
32. Neklason DW, Solomon CH, Dalton AL, Kuwada SK, Burt RW. Intron 4 mutation in APC gene results in splice defect and attenuated FAP phenotype. Fam Cancer. 2004; 3(1):35-40.
33. Rice PL, Kelloff J, Sullivan H, Driggers LJ, Beard KS, Kuwada S, Piazza G, Ahnen DJ. Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells. Mol Cancer Ther. 2003 Sep; 2(9):885-92.
34. Scaife CL, Kuang J, Wills JC, Trowbridge DB, Gray P, Manning BM, Eichwald EJ, Daynes RA, Kuwada SK. Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res. 2002 Dec 01; 62(23):6870-8.
35. Wills JC, Kuwada SK, Burt RW. "Hot spots" can burn you. Am J Gastroenterol. 2002 Mar; 97(3):757-8.
36. Clayton F, Kotler DP, Kuwada SK, Morgan T, Stepan C, Kuang J, Le J, Fantini J. Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy. Am J Pathol. 2001 Nov; 159(5):1933-9.
37. Kuwada SK, Burt RW. Prevention of colorectal cancer. Eur J Surg Suppl. 2001; (586):40-2.
38. Kuwada SK, Li X. Integrin alpha5/beta1 mediates fibronectin-dependent epithelial cell proliferation through epidermal growth factor receptor activation. Mol Biol Cell. 2000 Jul; 11(7):2485-96.
39. Kuwada SK. Carcinoid tumors. Semin Gastrointest Dis. 2000 Jul; 11(3):157-61.
40. Kuwada SK. Colorectal cancer 2000. Education and screening are essential if outcomes are to improve. Postgrad Med. 2000 May 01; 107(5):96-8, 101-4, 107.
41. Fox JR, Kuwada SK. Today''s approach to esophageal cancer. What is the role of the primary care physician? Postgrad Med. 2000 May 01; 107(5):109-14.
42. Damstrup L, Kuwada SK, Dempsey PJ, Brown CL, Hawkey CJ, Poulsen HS, Wiley HS, Coffey RJ. Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. Br J Cancer. 1999 Jun; 80(7):1012-9.
43. Kuwada SK, Li XF, Damstrup L, Dempsey PJ, Coffey RJ, Wiley HS. The dynamic expression of the epidermal growth factor receptor and epidermal growth factor ligand family in a differentiating intestinal epithelial cell line. Growth Factors. 1999; 17(2):139-53.
44. Kuwada SK, Lund KA, Li XF, Cliften P, Amsler K, Opresko LK, Wiley HS. Differential signaling and regulation of apical vs. basolateral EGFR in polarized epithelial cells. Am J Physiol. 1998 12; 275(6):C1419-28.
45. Rodriguez-Larrain JM, Ziebert JJ, Kfoury AG, Kuwada S, Taylor DO, Renlund DG. Incidence of adenomatous colorectal polyps in cardiac transplant recipients. Transplantation. 1997 Aug 15; 64(3):528-30.
46. Kuwada SK, Burt RW. The clinical features of the hereditary and nonhereditary polyposis syndromes. Surg Oncol Clin N Am. 1996 Jul; 5(3):553-67.
47. Kuwada SK, Balm R, Gostout CJ. The risk of withdrawing chronic anticoagulation because of acute GI bleeding. Am J Gastroenterol. 1996 Jun; 91(6):1116-9.
48. Kuwada SK, Alexander GL. Long-term outcome of endoscopic dilation of nonmalignant pyloric stenosis. Gastrointest Endosc. 1995 Jan; 41(1):15-7.
49. Kuwada SK, Patel VM, Hollinger FB, Lin HJ, Yarbough PO, Wiesner RH, Kaese D, Rakela J. Non-A, non-B fulminant hepatitis is also non-E and non-C. Am J Gastroenterol. 1994 Jan; 89(1):57-61.

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