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Serguei Skatchkov
Title Co-Coordinator
Faculty Rank Professor
Degree Ph.D.
Institution Universidad Central Del Caribe
Department Department of Physiology
Clusters Other
Address
Universidad Central del Caribe
Call Box 60-237
City Bayamon
State PR
Postal Code 00960
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Awards and Honors icon

1992 Ministry for Science and Art of Saxony, Germany Research Grant for Visiting Scientist
1995 Leningrad State University in Field of Inventions, Russia First Prize
2001 Co-Chairman (with Dr. A. Reichenbach) of 2nd International Müller (Glial) Cell Meeting, Germany
2006 Organizer of Annual Neuroscience Conference, Bayamon, PR, USA
2007 San Juan, PR Government Award for Accomplishments in Science
2008 Cozzarelli Prize -2007 from National Academy of Sciences, PNAS Office
2009 invited consultant, International glial research program “EduGLIA”
2012 Organizer of 1st and 2nd GIBE Satellite Glial Symposia in Puerto Rico

Narrative icon

  I am a Distinguished Professor at the Department of Physiology with over 15 years of experience on immunocytochemistry techniques. I have developed my skills through continuous collaborations with European investigators while pursuing my independent research goals and I have acted as coordinator of the RCMI funded immunocytochemistry laboratory for over 10 years.

My research has been funded during the past 16 years by NIH-NIGMS-MBRS, NHI-NINDS-SNRP, NIH-NCRR-RCMI and more recently NIH-NINDS R01 mechanisms. I currently direct the Integrative Center for Glial Research at Universidad Central del Caribe, a Center that is devoted to the study of glial cells in health and disease. My work in this area began in 1976 when I was an MS student and my first publications in 1979-80 highlighted a role of retinal glial cells in generation of electrical field potentials and K+-buffering. From 1980 to 1992, I worked on glia in Russia where I mentored students and trained junior faculty. In 1992, I was invited as a visiting researcher in the laboratory of Dr. Andreas Reichenbach in Germany where I established 3 novel directions of research and strong foreign collaborations including my current participation in the EduGlia network. A year later, Dr. Richard Orkand invited me to come to Puerto Rico from Germany to conduct glial research on the island. In 1997, I accepted a faculty position at UCC where I have had continuous funding with grants focusing on glial function in retina and brain.

I have served as reviewer for glial manuscripts, am past president of the Puerto Rico Chapter of the Society for Neuroscience and have trained 20 students (7 undergraduate and 13 graduate students) and 9 post-doctoral researchers. In addition, I am a consultant and expert visiting scientist for EduGlia. EduGlia is a European consortium which has the goal of training promising young researchers for careers in basic as well as in translational glial research, including clinical applications and industry.

NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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2020Glial Cells and Polyamine Signaling in the Central Nervous System1R15NS116478-01
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2013Polyamines and Brain Signaling5R01NS065201-04
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2012Polyamines and Brain Signaling5R01NS065201-03
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2012Polyamines and Brain Signaling3R01NS065201-03S1
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2011Polyamines and Brain Signaling5R01NS065201-02
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2010Polyamines and Brain Signaling1R01NS065201-01A2
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2002NEUROSCIENCE IMMUNOCYTOCHEMISTRY LABORATORY5G12RR003035-17
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2002A9A: VOLTAGE DEPENDENT ION CHANNELS IN HIPPOCAMPUS &SPERMINE MODULATION: STROKE5G12RR003035-17
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2000NEUROSCIENCE IMMUNOCYTOCHEMISTRY LABORATORY5G12RR003035-15
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2000A9A: VOLTAGE DEPENDENT ION CHANNELS IN HIPPOCAMPUS &SPERMINE MODULATION: STROKE5G12RR003035-15
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1999A9A: VOLTAGE DEPENDENT ION CHANNELS IN HIPPOCAMPUS &SPERMINE MODULATION: STROKE5G12RR003035-14
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1999A9A: VOLTAGE DEPENDENT ION CHANNELS IN HIPPOCAMPUS &SPERMINE MODULATION: STROKE3G12RR003035-14S2
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1999A9A: VOLTAGE DEPENDENT ION CHANNELS IN HIPPOCAMPUS &SPERMINE MODULATION: STROKE3G12RR003035-14S1
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1999NEUROSCIENCE IMMUNOCYTOCHEMISTRY LABORATORY3G12RR003035-14S2
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1998A9A: VOLTAGE DEPENDENT ION CHANNELS IN HIPPOCAMPUS &SPERMINE MODULATION: STROKE5G12RR003035-13
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1997A4A: VOLTAGE DEPENDENT ION CHANNELS IN HIPPOCAMPUS &SPERMINE MODULATION: STROKE5G12RR003035-12

Publications icon

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1. Rivera-Aponte DE, Melnik-Martínez KV, Malpica-Nieves CJ, Tejeda-Bayron F, Méndez-González MP, Skatchkov SN, Eaton MJ. Kir4.1 potassium channel regulation via microRNA-205 in astrocytes exposed to hyperglycemic conditions. Neuroreport. 2020 Apr 08; 31(6):450-455.
2. Méndez-González MP, Rivera-Aponte DE, Benedikt J, Maldonado-Martínez G, Tejeda-Bayron F, Skatchkov SN, Eaton MJ. Downregulation of Astrocytic Kir4.1 Potassium Channels Is Associated with Hippocampal Neuronal Hyperexcitability in Type 2 Diabetic Mice. Brain Sci. 2020 Jan 30; 10(2).
3. Khmelinskii I, Skatchkov SN, Makarov VI. Macro-scale transport of the excitation energy along a metal nanotrack: exciton-plasmon energy transfer mechanism. Sci Rep. 2019 Jan 14; 9(1):98.
4. Agte S, Savvinov A, Karl A, Zayas-Santiago A, Ulbricht E, Makarov VI, Reichenbach A, Bringmann A, Skatchkov SN. Müller glial cells contribute to dim light vision in the spectacled caiman (Caiman crocodilus fuscus): Analysis of retinal light transmission. Exp Eye Res. 2018 08; 173:91-108.
5. Rivera-Pagán AF, Méndez-González MP, Rivera-Aponte DE, Malpica-Nieves CJ, Melnik-Martínez KV, Zayas-Santiago A, Maldonado-Martínez G, Shuba YM, Skatchkov SN, Eaton MJ. A-Kinase-Anchoring Protein (AKAP150) is expressed in Astrocytes and Upregulated in Response to Ischemia. Neuroscience. 2018 08 01; 384:54-63.
6. Karl A, Agte S, Zayas-Santiago A, Makarov FN, Rivera Y, Benedikt J, Francke M, Reichenbach A, Skatchkov SN, Bringmann A. Retinal adaptation to dim light vision in spectacled caimans (Caiman crocodilus fuscus): Analysis of retinal ultrastructure. Exp Eye Res. 2018 08; 173:160-178.
7. Kucheryavykh LY, Benedikt J, Cubano LA, Skatchkov SN, Bukauskas FF, Kucheryavykh YV. Polyamines preserve connexin 43-mediated gap junctional communication during intracellular hypercalcemia and acidosis. Neuroreport. 2017 Mar 01; 28(4):208-213.
8. Méndez-González MP, Kucheryavykh YV, Zayas-Santiago A, Vélez-Carrasco W, Maldonado-Martínez G, Cubano LA, Nichols CG, Skatchkov SN, Eaton MJ. Novel KCNJ10 Gene Variations Compromise Function of Inwardly Rectifying Potassium Channel 4.1. J Biol Chem. 2016 Apr 01; 291(14):7716-26.
9. Olsen ML, Khakh BS, Skatchkov SN, Zhou M, Lee CJ, Rouach N. New Insights on Astrocyte Ion Channels: Critical for Homeostasis and Neuron-Glia Signaling. J Neurosci. 2015 Oct 14; 35(41):13827-35.
10. Rivera-Aponte DE, Méndez-González MP, Rivera-Pagán AF, Kucheryavykh YV, Kucheryavykh LY, Skatchkov SN, Eaton MJ. Hyperglycemia reduces functional expression of astrocytic Kir4.1 channels and glial glutamate uptake. Neuroscience. 2015 Dec 03; 310:216-23.
11. Rolón-Reyes K, Kucheryavykh YV, Cubano LA, Inyushin M, Skatchkov SN, Eaton MJ, Harrison JK, Kucheryavykh LY. Microglia Activate Migration of Glioma Cells through a Pyk2 Intracellular Pathway. PLoS One. 2015; 10(6):e0131059.
12. Skatchkov SN, Bukauskas FF, Benedikt J, Inyushin M, Kucheryavykh YV. Intracellular spermine prevents acid-induced uncoupling of Cx43 gap junction channels. Neuroreport. 2015 Jun 17; 26(9):528-32.
13. Rivera-Pagán AF, Rivera-Aponte DE, Melnik-Martínez KV, Zayas-Santiago A, Kucheryavykh LY, Martins AH, Cubano LA, Skatchkov SN, Eaton MJ. Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia. PLoS One. 2015; 10(4):e0125195.
14. Zueva L, Rivera Y, Kucheryavykh L, Skatchkov SN, Eaton MJ, Sanabria P, Inyushin M. Electron microscopy in rat brain slices reveals rapid accumulation of Cisplatin on ribosomes and other cellular components only in glia. Chemother Res Pract. 2014; 2014:174039.
15. Huertas A, Wessinger WD, Kucheryavykh YV, Sanabria P, Eaton MJ, Skatchkov SN, Rojas LV, Maldonado-Martínez G, Inyushin MY. Quinine enhances the behavioral stimulant effect of cocaine in mice. Pharmacol Biochem Behav. 2015 Feb; 129:26-33.
16. Zueva L, Makarov V, Zayas-Santiago A, Golubeva T, Korneeva E, Savvinov A, Eaton M, Skatchkov S, Inyushin M. Müller cell alignment in bird fovea: possible role in vision. J Neurosci Neuroeng. 2014 12 01; 3(2):85-91.
17. Skatchkov SN, Woodbury-Fariña MA, Eaton M. The role of glia in stress: polyamines and brain disorders. Psychiatr Clin North Am. 2014 Dec; 37(4):653-78.
18. Zayas-Santiago A, Agte S, Rivera Y, Benedikt J, Ulbricht E, Karl A, Dávila J, Savvinov A, Kucheryavykh Y, Inyushin M, Cubano LA, Pannicke T, Veh RW, Francke M, Verkhratsky A, Eaton MJ, Reichenbach A, Skatchkov SN. Unidirectional photoreceptor-to-Müller glia coupling and unique K+ channel expression in Caiman retina. PLoS One. 2014; 9(5):e97155.
19. Kucheryavykh LY, Rolón-Reyes K, Kucheryavykh YV, Skatchkov S, Eaton MJ, Sanabria P, Wessinger WD, Inyushin M. Glioblastoma development in mouse brain: general reduction of OCTs and mislocalization of OCT3 transporter and subsequent uptake of ASP+ substrate to the nuclei. J Neurosci Neuroeng. 2014 Feb; 3(1):3-9.
20. Makarov V, Kucheryavykh L, Kucheryavykh Y, Rivera A, Eaton MJ, Skatchkov SN, Inyushin M. Transport Reversal during Heteroexchange: A Kinetic Study. J Biophys. 2013; 2013:683256.
21. Abushik PA, Sibarov DA, Eaton MJ, Skatchkov SN, Antonov SM. Kainate-induced calcium overload of cortical neurons in vitro: Dependence on expression of AMPAR GluA2-subunit and down-regulation by subnanomolar ouabain. Cell Calcium. 2013 Aug; 54(2):95-104.
22. Sala-Rabanal M, Li DC, Dake GR, Kurata HT, Inyushin M, Skatchkov SN, Nichols CG. Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3. Mol Pharm. 2013 Apr 01; 10(4):1450-8.
23. Benedikt J, Inyushin M, Kucheryavykh YV, Rivera Y, Kucheryavykh LY, Nichols CG, Eaton MJ, Skatchkov SN. Intracellular polyamines enhance astrocytic coupling. Neuroreport. 2012 Dec 05; 23(17):1021-5.
24. Kucheryavykh LY, Kucheryavykh YV, Rolón-Reyes K, Skatchkov SN, Eaton MJ, Cubano LA, Inyushin M. Visualization of implanted GL261 glioma cells in living mouse brain slices using fluorescent 4-(4-(dimethylamino)-styryl)-N-methylpyridinium iodide (ASP+). Biotechniques. 2012 Nov; 53(5):305-9.
25. Inyushin MY, Huertas A, Kucheryavykh YV, Kucheryavykh LY, Tsydzik V, Sanabria P, Eaton MJ, Skatchkov SN, Rojas LV, Wessinger WD. L-DOPA Uptake in Astrocytic Endfeet Enwrapping Blood Vessels in Rat Brain. Parkinsons Dis. 2012; 2012:321406.
26. Seidel KN, Derst C, Salzmann M, Höltje M, Priller J, Markgraf R, Heinemann SH, Heilmann H, Skatchkov SN, Eaton MJ, Veh RW, Prüss H. Expression of the voltage- and Ca2+-dependent BK potassium channel subunits BKß1 and BKß4 in rodent astrocytes. Glia. 2011 Jun; 59(6):893-902.
27. Inyushin M, Kucheryavykh LY, Kucheryavykh YV, Nichols CG, Buono RJ, Ferraro TN, Skatchkov SN, Eaton MJ. Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. Epilepsia. 2010 Sep; 51(9):1707-13.
28. Sala-Rabanal M, Kucheryavykh LY, Skatchkov SN, Eaton MJ, Nichols CG. Molecular mechanisms of EAST/SeSAME syndrome mutations in Kir4.1 (KCNJ10). J Biol Chem. 2010 Nov 12; 285(46):36040-8.
29. Inyushin M, Kucheryaykh Y, Kucheryavykh L, Sanabria P, Jiménez-Rivera C, Struganova I, Eaton M, Skatchkov S. Membrane potential and pH-dependent accumulation of decynium-22 (1,1''-diethyl-2,2''-cyanine iodide) flourencence through OCT transporters in astrocytes. Bol Asoc Med P R. 2010 Jul-Sep; 102(3):5-12.
30. Kucheryavykh LY, Kucheryavykh YV, Inyushin M, Shuba YM, Sanabria P, Cubano LA, Skatchkov SN, Eaton MJ. Ischemia Increases TREK-2 Channel Expression in Astrocytes: Relevance to Glutamate Clearance. Open Neurosci J. 2009 Jan 01; 3:40-47.
31. Acevedo-Torres K, Berríos L, Rosario N, Dufault V, Skatchkov S, Eaton MJ, Torres-Ramos CA, Ayala-Torres S. Mitochondrial DNA damage is a hallmark of chemically induced and the R6/2 transgenic model of Huntington''s disease. DNA Repair (Amst). 2009 Jan 01; 8(1):126-36.
32. Kucheryavykh YV, Shuba YM, Antonov SM, Inyushin MY, Cubano L, Pearson WL, Kurata H, Reichenbach A, Veh RW, Nichols CG, Eaton MJ, Skatchkov SN. Complex rectification of Müller cell Kir currents. Glia. 2008 May; 56(7):775-90.
33. Franze K, Grosche J, Skatchkov SN, Schinkinger S, Foja C, Schild D, Uckermann O, Travis K, Reichenbach A, Guck J. Muller cells are living optical fibers in the vertebrate retina. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8287-92.
34. Kucheryavykh YV, Pearson WL, Kurata HT, Eaton MJ, Skatchkov SN, Nichols CG. Polyamine permeation and rectification of Kir4.1 channels. Channels (Austin). 2007 May-Jun; 1(3):172-8.
35. Pearson WL, Skatchkov SN, Eaton MJ, Nichols CG. C-terminal determinants of Kir4.2 channel expression. J Membr Biol. 2006; 213(3):187-93.
36. Kucheryavykh YV, Kucheryavykh LY, Nichols CG, Maldonado HM, Baksi K, Reichenbach A, Skatchkov SN, Eaton MJ. Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes. Glia. 2007 Feb; 55(3):274-81.
37. Bringmann A, Pannicke T, Grosche J, Francke M, Wiedemann P, Skatchkov SN, Osborne NN, Reichenbach A. Müller cells in the healthy and diseased retina. Prog Retin Eye Res. 2006 Jul; 25(4):397-424.
38. Krivoi II, Drabkina TM, Kravtsova VV, Vasiliev AN, Eaton MJ, Skatchkov SN, Mandel F. On the functional interaction between nicotinic acetylcholine receptor and Na+,K+-ATPase. Pflugers Arch. 2006 Sep; 452(6):756-65.
39. Skatchkov SN, Eaton MJ, Shuba YM, Kucheryavykh YV, Derst C, Veh RW, Wurm A, Iandiev I, Pannicke T, Bringmann A, Reichenbach A. Tandem-pore domain potassium channels are functionally expressed in retinal (Müller) glial cells. Glia. 2006 Feb; 53(3):266-76.
40. Schopf S, Ruge H, Bringmann A, Reichenbach A, Skatchkov SN. Switch of K+ buffering conditions in rabbit retinal Müller glial cells during postnatal development. Neurosci Lett. 2004 Jul 29; 365(3):167-70.
41. Eaton MJ, Veh RW, Makarov F, Shuba YM, Reichenbach A, Skatchkov SN. Tandem-pore K(+) channels display an uneven distribution in amphibian retina. Neuroreport. 2004 Feb 09; 15(2):321-4.
42. Raap M, Biedermann B, Braun P, Milenkovic I, Skatchkov SN, Bringmann A, Reichenbach A. Diversity of Kir channel subunit mRNA expressed by retinal glial cells of the guinea-pig. Neuroreport. 2002 Jun 12; 13(8):1037-40.
43. Skatchkov SN, Rojas L, Eaton MJ, Orkand RK, Biedermann B, Bringmann A, Pannicke T, Veh RW, Reichenbach A. Functional expression of Kir 6.1/SUR1-K(ATP) channels in frog retinal Müller glial cells. Glia. 2002 May; 38(3):256-67.
44. Eaton MJ, Skatchkov SN, Brune A, Biedermann B, Veh RW, Reichenbach A. SURI and Kir6.1 subunits of K(ATP)-channels are co-localized in retinal glial (Müller) cells. Neuroreport. 2002 Jan 21; 13(1):57-60.
45. Bolshakov KV, Essin KV, Buldakova SL, Dorofeeva NA, Skatchkov SN, Eaton MJ, Tikhonov DB, Magazanik LG. Characterization of acid-sensitive ion channels in freshly isolated rat brain neurons. Neuroscience. 2002; 110(4):723-30.
46. Thomzig A, Wenzel M, Karschin C, Eaton MJ, Skatchkov SN, Karschin A, Veh RW. Kir6.1 is the principal pore-forming subunit of astrocyte but not neuronal plasma membrane K-ATP channels. Mol Cell Neurosci. 2001 Dec; 18(6):671-90.
47. Skatchkov SN, Thomzig A, Eaton MJ, Biedermann B, Eulitz D, Bringmann A, Pannicke T, Veh RW, Reichenbach A. Kir subfamily in frog retina: specific spatial distribution of Kir 6.1 in glial (Müller) cells. Neuroreport. 2001 May 25; 12(7):1437-41.
48. Bringmann A, Skatchkov SN, Faude F, Enzmann V, Reichenbach A. Farnesol modulates membrane currents in human retinal glial cells. J Neurosci Res. 2000 Nov 01; 62(3):396-402.
49. Bringmann A, Skatchkov SN, Pannicke T, Biedermann B, Wolburg H, Orkand RK, Reichenbach A. Müller glial cells in anuran retina. Microsc Res Tech. 2000 Sep 01; 50(5):384-93.
50. Skatchkov SN, Eaton MJ, Krusek J, Veh RW, Biedermann B, Bringmann A, Pannicke T, Orkand RK, Reichenbach A. Spatial distribution of spermine/spermidine content and K(+)-current rectification in frog retinal glial (Müller) cells. Glia. 2000 Jul; 31(1):84-90.
51. Bringmann A, Pannicke T, Reichenbach A, Skatchkov SN. Ca(2+) channel-mediated currents in retinal glial (Müller) cells of the toad (Bufo marinus). Neurosci Lett. 2000 Mar 10; 281(2-3):155-8.
52. Skatchkov SN, Krusek J, Reichenbach A, Orkand RK. Potassium buffering by Müller cells isolated from the center and periphery of the frog retina. Glia. 1999 Aug; 27(2):171-80.
53. Bringmann A, Schopf S, Faude F, Skatchkov SN, Enzmann V, Reichenbach A. The activity of a transient potassium current in retinal glial (Müller) cells depends on extracellular calcium. J Hirnforsch. 1999; 39(4):539-50.
54. Bringmann A, Skatchkov SN, Biedermann B, Faude F, Reichenbach A. Alterations of potassium channel activity in retinal Müller glial cells induced by arachidonic acid. Neuroscience. 1998 Oct; 86(4):1291-306.
55. Biedermann B, Skatchkov SN, Brunk I, Bringmann A, Pannicke T, Bernstein HG, Faude F, Germer A, Veh R, Reichenbach A. Spermine/spermidine is expressed by retinal glial (Müller) cells and controls distinct K+ channels of their membrane. Glia. 1998 Jul; 23(3):209-20.
56. Knabe W, Skatchkov S, Kuhn HJ. "Lens mitochondria" in the retinal cones of the tree-shrew Tupaia belangeri. Vision Res. 1997 Feb; 37(3):267-71.
57. Reichenbach A, Faude F, Enzmann V, Bringmann A, Pannicke T, Francke M, Biedermann B, Kuhrt H, Stolzenburg JU, Skatchkov SN, Heinemann U, Wiedemann P, Reichelt W. The Müller (glial) cell in normal and diseased retina: a case for single-cell electrophysiology. Ophthalmic Res. 1997; 29(5):326-40.
58. Skatchkov SN, Vyklicky L, Clasen T, Orkand RK. Effect of cutting the optic nerve on K+ currents in endfeet of Muller cells isolated from frog retina. Neurosci Lett. 1996 Apr 19; 208(2):81-4.
59. Skatchkov SN, Vyklický L, Orkand RK. Potassium currents in endfeet of isolated Müller cells from the frog retina. Glia. 1995 Sep; 15(1):54-64.
60. Skatchkov S, Brösamle C, Vyklický L, Kuffler DP, Orkand RK. NMDA receptors on adult frog spinal motoneurons in culture. Neurosci Lett. 1994 Aug 01; 176(2):251-4.

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