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overview I am an Associate Professor of Biochemistry and Molecular Biology at Howard University, Washington D.C. I obtained my PhD in Molecular Biology from Queen Mary & Westfield College (University of London, UK) where I carried out studies using Cre-loxP site-specific recombination system to design chromosomal translation in transgenic animal model. I carried out my post-doctoral training at Baylor College of Medicine, Houston TX where I undertook research studies of the molecular mechanisms underlying dys-regulation of receptor tyrosine signaling in prostate cancer. I subsequently joined Howard University cancer Center in 2007 as an Assistant Professor and become an Associate Professor in 2011. Currently, I serve as a Principle Investigator of a prostate cancer research laboratory. The focus of my research is 3 fold: First, to understand the role of epigenetic alterations in regulating gene expression in prostate cancer. Second, to evaluate and implement tools for quantitative DNA methylation analysis in support of differences in prostate cancer tumor biology and prostate cancer disparity and finally, to understand how DNA methylation changes can be explored as potential biomarkers (ethnic sensitive biomarkers) for the early detection of cancer and/or progression of the disease.
One or more keywords matched the following items that are connected to Kwabi-Addo, Bernard
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Academic Article Transcriptional and post-transcriptional regulation of Sprouty1, a receptor tyrosine kinase inhibitor in prostate cancer.
Academic Article Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men.
Academic Article Relationship between tumor DNA methylation status and patient characteristics in African-American and European-American women with breast cancer.
Academic Article Absence of PTEN/MMAC1 pseudogene in mice.
Academic Article Humanizing p-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose.
Academic Article Identification of novel DNA-methylated genes that correlate with human prostate cancer and high-grade prostatic intraepithelial neoplasia.
Academic Article DNA methylation profile associated with rapid decline in kidney function: findings from the CRIC study.
Academic Article Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer.
Academic Article Correlating blood-based DNA methylation markers and prostate cancer risk in African-American men.
Academic Article Association of Genetic Ancestry With DNA Methylation Changes in Prostate Cancer Disparity.
Academic Article Androgen-induced Epigenetic Profiles of Polycomb and Trithorax Genes in Prostate Cancer Cells.
Academic Article The expression of Sprouty1, an inhibitor of fibroblast growth factor signal transduction, is decreased in human prostate cancer.
Academic Article Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.
Academic Article A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination.
Academic Article Allele-specific methylation of a functional CTCF binding site upstream of MEG3 in the human imprinted domain of 14q32.
Academic Article Age-related DNA methylation changes in normal human prostate tissues.
Academic Article Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
Academic Article DNA methylation and aberrant expression of Sprouty1 in human prostate cancer.
Academic Article Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling.
Concept DNA
Concept DNA Mutational Analysis
Concept DNA-Binding Proteins
Concept Sequence Analysis, DNA
Concept DNA Primers
Concept DNA Methylation
Academic Article DNA methylation and exposure to violence among African American young adult males.
Academic Article Sex differences in saliva-based DNA methylation changes and environmental stressor in young African American adults.
Academic Article Aerobic Exercise Training-Induced Changes on DNA Methylation in Mild Cognitively Impaired Elderly African Americans: Gene, Exercise, and Memory Study - GEMS-I.
Academic Article Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer.
Academic Article Mechanism of Antitumor Effects of Saffron in Human Prostate Cancer Cells.
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