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Ashktorab, Hassan

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overview	Gastroenterology cancer research group at HU Cancer Center Dr. Hassan Ashktorab is Professor in the Departments of Medicine. He serves, or has served as the member of gastrointestinal working group in the Howard University Cancer Center, executive member of The Howard University Cancer Center, Adjunct Professor at The Department of Genetics and Human Genetics and the Director of Microarray facility at Howard University and former Chair of College of Medicine Research committee. He is a member of the Editorial boards of PLoS One, Digestive Diseases and Science, World Journal of Gastroenterology and Gouvaresh and former Editorial Board member of Gut. He has been awarded several NIH grants including RO3, RO1 and DOD grants. He received the HU-COM Outstanding Researcher Award in 2011. He has been a member of different NIH study sections since 2005. Dr. Ashktorab’s group focus is on epigenetics, genetics and epidemiology of gastrointestinal cancers especially colorectal cancer. Gastroenterology Research: Gastroenterology laboratory is investigating the molecular mechanisms governing cellular proliferation, including epigenetic and genetic influence during oncogenic transformation and tumorigenesis. The long term goals include the identification and characterization of epigenetic factors such as DNA methylation, miRNA and histone modifications that play a central and direct role in the initiation and/or progression of human cancers, specifically gastric and colon cancer. This includes research on chromatin modification through methylation or acetylation of genes/histones that may play critical roles in the regulation of transcription of many genes, leading to alteration of cell function and cell cycle. In addition, the detection of DNA methylation biomarkers for both early detection and prognosis is part of our interests using Next Generation Sequencing (NGS). We have recently detected several epigenetic biomarkers that are hypermethylated significantly in tumors from African Americans compared to Caucasians. Dr. Ashktorab’s translational/clinical research focuses on the African American population, investigating genomic instability and gene silencing in patients with adenoma and colorectal cancer. This is a critical step for the understanding of the onset of cancer progression in African Americans with the goal of tackling this health disparity in this population. NGS is revolutionizing medicine and health care approaches. As it becomes cheaper and more accessible, more in-depth personalized genomic information will be available that dictates more appropriate and individualized approaches for both detection and treatment. Dr. Ashktorab’s NGS research recently identified novel mutations in African Americans with colorectal cancer which were highlighted in the Journal Cancer. His group is working toward biomarkers identification in early to late colorectal carcinogenesis. One of the genes that is an early marker in colorectal carcinogenesis is APC. This gene is part of WNT pathway and his group found novel mutations in African Americans with colorectal cancer which is highlighted in Cancer and PNAS 2015. The identification of these biomarkers will help in the detection, prognostic and treatment of the patients. The NGS research is followed by targeted exome sequencing for gene panels in detect colorectal cancer specifically in African Americans. Much of the sporadic colorectal cancer’s underlying genetic mutations (driver genes) are unknown in patients from specific ethnic groups such as African Americans. We also reported the identification of distinct novel variants from adenoma and CRC patients in mismatch repair (MMR) genes MHS3 and MSH6, and in PIK3CA. A new line of research was recently developed with Dr. Brim in the context of the role that the gut microbiota might play in the initiation and progression of colon neoplasia. Dr. Brim is a faculty at the Department of Pathology. Several publications have pointed to potential roles of specific bacteria in triggering genetic and epigenetic events such as those described in colon carcinogenesis. The primary goal of this line of research is to define specific bacteria that associate with higher risk of neoplasia. This will likely offer the opportunity to intervene at the gut microbiota’s level to reduce the risk of colon carcinogenesis. We are also collaborating with Dr. Laiyemo, a gastroenterologist and Dr. Nouraie Faculty at the College of medicine, on several epidemiological studies that seek to assess factors at play in the adherence to colonoscopy and treatment in minority patients. Along with our genetic, epigenetic, microbiomic and epidemiological studies that target colorectal cancer in African Americans, we are also investigating such a disease in other minorities such as Hispanics. We are also investigating other gastrointestinal diseases through several ongoing epidemiological studies such as hepatic fibrosis, hepatocellular carcinoma, gastroesophageal reflux disease, esophageal cancer and anal cancer in African Americans among several other projects. Please visit PubMed for the recent publications.

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Value

overview

Gastroenterology cancer research group at HU Cancer Center Dr. Hassan Ashktorab is Professor in the Departments of Medicine. He serves, or has served as the member of gastrointestinal working group in the Howard University Cancer Center, executive member of The Howard University Cancer Center, Adjunct Professor at The Department of Genetics and Human Genetics and the Director of Microarray facility at Howard University and former Chair of College of Medicine Research committee. He is a member of the Editorial boards of PLoS One, Digestive Diseases and Science, World Journal of Gastroenterology and Gouvaresh and former Editorial Board member of Gut. He has been awarded several NIH grants including RO3, RO1 and DOD grants. He received the HU-COM Outstanding Researcher Award in 2011. He has been a member of different NIH study sections since 2005. Dr. Ashktorab’s group focus is on epigenetics, genetics and epidemiology of gastrointestinal cancers especially colorectal cancer. Gastroenterology Research: Gastroenterology laboratory is investigating the molecular mechanisms governing cellular proliferation, including epigenetic and genetic influence during oncogenic transformation and tumorigenesis. The long term goals include the identification and characterization of epigenetic factors such as DNA methylation, miRNA and histone modifications that play a central and direct role in the initiation and/or progression of human cancers, specifically gastric and colon cancer. This includes research on chromatin modification through methylation or acetylation of genes/histones that may play critical roles in the regulation of transcription of many genes, leading to alteration of cell function and cell cycle. In addition, the detection of DNA methylation biomarkers for both early detection and prognosis is part of our interests using Next Generation Sequencing (NGS). We have recently detected several epigenetic biomarkers that are hypermethylated significantly in tumors from African Americans compared to Caucasians. Dr. Ashktorab’s translational/clinical research focuses on the African American population, investigating genomic instability and gene silencing in patients with adenoma and colorectal cancer. This is a critical step for the understanding of the onset of cancer progression in African Americans with the goal of tackling this health disparity in this population. NGS is revolutionizing medicine and health care approaches. As it becomes cheaper and more accessible, more in-depth personalized genomic information will be available that dictates more appropriate and individualized approaches for both detection and treatment. Dr. Ashktorab’s NGS research recently identified novel mutations in African Americans with colorectal cancer which were highlighted in the Journal Cancer. His group is working toward biomarkers identification in early to late colorectal carcinogenesis. One of the genes that is an early marker in colorectal carcinogenesis is APC. This gene is part of WNT pathway and his group found novel mutations in African Americans with colorectal cancer which is highlighted in Cancer and PNAS 2015. The identification of these biomarkers will help in the detection, prognostic and treatment of the patients. The NGS research is followed by targeted exome sequencing for gene panels in detect colorectal cancer specifically in African Americans. Much of the sporadic colorectal cancer’s underlying genetic mutations (driver genes) are unknown in patients from specific ethnic groups such as African Americans. We also reported the identification of distinct novel variants from adenoma and CRC patients in mismatch repair (MMR) genes MHS3 and MSH6, and in PIK3CA. A new line of research was recently developed with Dr. Brim in the context of the role that the gut microbiota might play in the initiation and progression of colon neoplasia. Dr. Brim is a faculty at the Department of Pathology. Several publications have pointed to potential roles of specific bacteria in triggering genetic and epigenetic events such as those described in colon carcinogenesis. The primary goal of this line of research is to define specific bacteria that associate with higher risk of neoplasia. This will likely offer the opportunity to intervene at the gut microbiota’s level to reduce the risk of colon carcinogenesis. We are also collaborating with Dr. Laiyemo, a gastroenterologist and Dr. Nouraie Faculty at the College of medicine, on several epidemiological studies that seek to assess factors at play in the adherence to colonoscopy and treatment in minority patients. Along with our genetic, epigenetic, microbiomic and epidemiological studies that target colorectal cancer in African Americans, we are also investigating such a disease in other minorities such as Hispanics. We are also investigating other gastrointestinal diseases through several ongoing epidemiological studies such as hepatic fibrosis, hepatocellular carcinoma, gastroesophageal reflux disease, esophageal cancer and anal cancer in African Americans among several other projects. Please visit PubMed for the recent publications.

One or more keywords matched the following items that are connected to Ashktorab, Hassan

Item Type	Name
Grant	Mechanisms of Growth Inhibition by Helicobacter Pylor
Grant	METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
Academic Article	A 50-year review of colorectal cancer in African Americans: implications for prevention and treatment.
Academic Article	Distinct genetic alterations in colorectal cancer.
Academic Article	MTHFR C677T and A1298C variant genotypes and the risk of microsatellite instability among Iranian colorectal cancer patients.
Academic Article	ITIH3 is a potential biomarker for early detection of gastric cancer.
Academic Article	Upregulation of plasma C9 protein in gastric cancer patients.
Academic Article	NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
Academic Article	The impact of C-MYC gene expression on gastric cancer cell.
Academic Article	Cathepsin S mediates gastric cancer cell migration and invasion via a putative network of metastasis-associated proteins.
Academic Article	SLC5A8 gene, a transporter of butyrate: a gut flora metabolite, is frequently methylated in African American colon adenomas.
Academic Article	Esophageal carcinoma in African Americans: a five-decade experience.
Academic Article	Distinct high-profile methylated genes in colorectal cancer.
Academic Article	Outcome of colonoscopy in elderly African-American patients.
Academic Article	Effects of Helicobacter pylori on proliferation of gastric epithelial cells in vitro.
Academic Article	CD44-SLC1A2 gene fusions in gastric cancer.
Academic Article	SEL1L, an UPR response protein, a potential marker of colonic cell transformation.
Academic Article	Linkage disequilibrium and haplotype analysis of COX-2 and risk of colorectal adenoma development.
Academic Article	Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor ? activation pathway in gastric cancer.
Academic Article	SILAC-based quantitative proteomic analysis of gastric cancer secretome.
Academic Article	Gastrokine 1 regulates NF-?B signaling pathway and cytokine expression in gastric cancers.
Academic Article	ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability.
Academic Article	Role of life events in the presence of colon polyps among African Americans.
Academic Article	Toward a comprehensive and systematic methylome signature in colorectal cancers.
Academic Article	Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans.
Academic Article	MicroRNA-211 expression promotes colorectal cancer cell growth in vitro and in vivo by targeting tumor suppressor CHD5.
Academic Article	LARP7 is a potential tumor suppressor gene in gastric cancer.
Academic Article	Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.
Academic Article	Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients.
Academic Article	Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.
Academic Article	Short- and long-term risk of colorectal adenoma recurrence among whites and blacks.
Academic Article	GKN1-miR-185-DNMT1 axis suppresses gastric carcinogenesis through regulation of epigenetic alteration and cell cycle.
Academic Article	Prevalence of colorectal neoplasia among young African Americans and Hispanic Americans.
Academic Article	Epigenetic silencing of CHD5, a novel tumor-suppressor gene, occurs in early colorectal cancer stages.
Academic Article	MicroRNA 135a suppresses lymph node metastasis through down-regulation of ROCK1 in early gastric cancer.
Academic Article	An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors.
Academic Article	BMI and the risk of colorectal adenoma in African-Americans.
Academic Article	Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans.
Academic Article	The effect of Helicobacter pylori CagA on the HER-2 copy number and expression in gastric cancer.
Academic Article	DNA Methylation and Colorectal Cancer.
Academic Article	GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity.
Academic Article	DNA methylome profiling identifies novel methylated genes in African American patients with colorectal neoplasia.
Academic Article	nc886, a non-coding RNA of anti-proliferative role, is suppressed by CpG DNA methylation in human gastric cancer.
Academic Article	A role for RUNX3 in inflammation-induced expression of IL23A in gastric epithelial cells.
Academic Article	Gastrokine 1 inhibits the carcinogenic potentials of Helicobacter pylori CagA.
Academic Article	Identification of novel mutations by exome sequencing in African American colorectal cancer patients.
Academic Article	Gastrokine 1 inhibits gastrin-induced cell proliferation.
Academic Article	Next-generation sequencing in African Americans with colorectal cancer.
Academic Article	Race and colorectal cancer screening compliance among persons with a family history of cancer.
Academic Article	Lymph nodes' evaluation in relation to colorectal cancer staging among African Americans.
Academic Article	Prevalence and features of colorectal lesions among Hispanics: A hospital-based study.
Academic Article	Colorectal Cancer in Young African Americans: Is It Time to Revisit Guidelines and Prevention?
Academic Article	Targeted Exome Sequencing Outcome Variations of Colorectal Tumors within and across Two Sequencing Platforms.
Academic Article	Fecal Bacteria Act as Novel Biomarkers for Noninvasive Diagnosis of Colorectal Cancer.
Academic Article	Heterodimeric interaction between GKN2 and TFF1 entails synergistic antiproliferative and pro-apoptotic effects on gastric cancer cells.
Academic Article	IL1B-CGTC haplotype is associated with colorectal cancer in admixed individuals with increased African ancestry.
Academic Article	Atrial Fibrillation and Colonic Neoplasia in African Americans.
Academic Article	Genetic Basis for Colorectal Cancer Disparities.
Academic Article	A meta-analysis of MSI frequency and race in colorectal cancer.
Academic Article	Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk.
Academic Article	Can optical diagnosis of small colon polyps be accurate? Comparing standard scope without narrow banding to high definition scope with narrow banding.
Academic Article	Reduced Representation Bisulfite Sequencing Determination of Distinctive DNA Hypermethylated Genes in the Progression to Colon Cancer in African Americans.
Academic Article	Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness.
Academic Article	Genomics of Colorectal Cancer in African Americans.
Academic Article	Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer.
Academic Article	Epigenomic Promoter Alterations Amplify Gene Isoform and Immunogenic Diversity in Gastric Adenocarcinoma.
Academic Article	PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer.
Academic Article	Histone isoform H2A1H promotes attainment of distinct physiological states by altering chromatin dynamics.
Academic Article	Verteporfin inhibits gastric cancer cell growth by suppressing adhesion molecule FAT1.
Academic Article	Distinctive DNA mismatch repair and APC rare variants in African Americans with colorectal neoplasia.
Academic Article	A Comparison Between Cell, Protein and Peptide-Based Approaches for Selection of Nanobodies Against CD44 from a Synthetic Library.
Academic Article	Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.
Academic Article	KMT2C Mutations in Diffuse-Type Gastric Adenocarcinoma Promote Epithelial-to-Mesenchymal Transition.
Academic Article	GPNMB methylation: a new marker of potentially carcinogenic colon lesions.
Academic Article	Multiple genetic mutations caused by NKX6.3 depletion contribute to gastric tumorigenesis.
Academic Article	Inhibition of miR-194 suppresses the Wnt/?-catenin signalling pathway in gastric cancer.
Academic Article	Novel circular RNA circNF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16.
Academic Article	Racial Disparity in Gastrointestinal Cancer Risk.
Academic Article	Adiponectin, Leptin, IGF-1, and Tumor Necrosis Factor Alpha As Potential Serum Biomarkers for Non-Invasive Diagnosis of Colorectal Adenoma in African Americans.
Academic Article	YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC.
Academic Article	Screening and Identification of Peptides Specifically Targeted to Gastric Cancer Cells from a Phage Display Peptide Library
Academic Article	Gastrokine 1 protein is a potential theragnostic target for gastric cancer.
Academic Article	Correction: Verteporfin inhibits gastric cancer cell growth by suppressing adhesion molecule FAT1.
Academic Article	NKX6.3 protects against gastric mucosal atrophy by downregulating ?-amyloid production.
Academic Article	Driver genes exome sequencing reveals distinct variants in African Americans with colorectal neoplasia.
Academic Article	Can the rate and location of sessile serrated polyps be part of colorectal Cancer disparity in African Americans?
Academic Article	CDX1 Expression Induced by CagA-Expressing Helicobacter pylori Promotes Gastric Tumorigenesis.
Academic Article	Using Patients' Social Network to Improve Compliance to Outpatient Screening Colonoscopy Appointments Among Blacks: A Randomized Clinical Trial.
Academic Article	KRAS mutation and abnormal expression of Cripto-1 as two potential candidate biomarkers for detection of colorectal cancer development.
Academic Article	Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer.
Academic Article	miRNA-192 and -215 activate Wnt/?-catenin signaling pathway in gastric cancer via APC.
Academic Article	Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer.
Academic Article	Molecular Signatures of JMJD10/MINA53 in Gastric Cancer.
Academic Article	Molecular Characterization of Sessile Serrated Adenoma/Polyps From a Large African American Cohort.
Academic Article	HNF4a pathway mapping identifies wild-type IDH1 as a targetable metabolic node in gastric cancer.
Academic Article	Genipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer.
Academic Article	Elevated Risk for Sessile Serrated Polyps in African Americans with Endometrial Polyps.
Academic Article	Genipin increases oxaliplatin-induced cell death through autophagy in gastric cancer.
Academic Article	Uptake and tumor-suppressive pathways of exosome-associated GKN1 protein in gastric epithelial cells.
Academic Article	Altered ARID1A expression in colorectal cancer.
Academic Article	Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells.
Academic Article	In vivo and in vitro activation of caspase-8 and -3 associated with Helicobacter pylori infection.
Academic Article	Helicobacter pylori inhibits gastric cell cycle progression.
Academic Article	High incidence of microsatellite instability in colorectal cancer from African Americans.
Academic Article	p53 and p14 increase sensitivity of gastric cells to H. pylori-induced apoptosis.
Academic Article	Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori.
Academic Article	Association between Helicobacter pylori Infection in gastric cancer, ulcers and gastritis in Iranian patients.
Academic Article	Clinicopathological features and microsatellite instability (MSI) in colorectal cancers from African Americans.
Academic Article	Apoptosis induced by aspirin and 5-fluorouracil in human colonic adenocarcinoma cells.
Academic Article	Helicobacter pylori endemic and gastric disease.
Academic Article	Folate status and risk of colorectal polyps in African Americans.
Academic Article	Transactivation of the EGFR by AP-1 is induced by Helicobacter pylori in gastric cancer.
Academic Article	Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects.
Academic Article	H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria.
Academic Article	Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans.
Academic Article	Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study.
Academic Article	Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans.
Academic Article	Global histone H4 acetylation and HDAC2 expression in colon adenoma and carcinoma.
Concept	Anus Neoplasms
Concept	Colonic Neoplasms
Concept	Digestive System Neoplasms
Concept	DNA, Neoplasm
Concept	Esophageal Neoplasms
Concept	Liver Neoplasms
Concept	Neoplasm Invasiveness
Concept	Neoplasm Metastasis
Concept	Neoplasm Proteins
Concept	Neoplasm Recurrence, Local
Concept	Neoplasm Staging
Concept	Neoplasm Transplantation
Concept	Neoplasms
Concept	Prostatic Neoplasms
Concept	RNA, Neoplasm
Concept	Stomach Neoplasms
Concept	Tumor Cells, Cultured
Concept	Tumor Necrosis Factor-alpha
Concept	Colorectal Neoplasms
Concept	Genes, Tumor Suppressor
Concept	Tumor Suppressor Protein p53
Concept	Tumor Suppressor Proteins
Concept	Tumor Suppressor Protein p14ARF
Concept	Cell Line, Tumor
Concept	Genes, Neoplasm
Concept	Early Detection of Cancer
Academic Article	Saffron Crudes and Compounds Restrict MACC1-Dependent Cell Proliferation and Migration of Colorectal Cancer Cells.
Academic Article	SUFU mediates EMT and Wnt/?-catenin signaling pathway activation promoted by miRNA-324-5p in human gastric cancer.
Academic Article	Association of Patients' Perception of Quality of Healthcare Received and Colorectal Cancer Screening Uptake: An Analysis of 2 National Surveys in the USA.
Academic Article	Association of Human Papillomavirus Genotype 16 Lineages With Anal Cancer Histologies Among African Americans.
Academic Article	Histone methyltransferase SET8 is regulated by miR-192/215 and induces oncogene-induced senescence via p53-dependent DNA damage in human gastric carcinoma cells.
Academic Article	Analysis of ?-catenin association with obesity in African Americans with premalignant and malignant colorectal lesions.
Academic Article	Lymphatic metastasis-related TBL1XR1 enhances stemness and metastasis in gastric cancer stem-like cells by activating ERK1/2-SOX2 signaling.
Academic Article	Association of Colonic Diverticula with Colorectal Adenomas and Cancer.
Academic Article	Helicobacter pylori-induced gastric cancer is orchestrated by MRCK?-mediated Siah2 phosphorylation.
Academic Article	Dual activation of Hedgehog and Wnt/?-catenin signaling pathway caused by downregulation of SUFU targeted by miRNA-150 in human gastric cancer.
Academic Article	Blood-Based Liquid Biopsies: A Noninvasive and Cost-Effective Tool for Improved Risk Assessment and Identification of Lymph Node Metastasis in Patients With Submucosal T1 Colorectal Cancer.
Academic Article	Trends in the Incidence of Hepatocellular Carcinoma in Washington DC: A Single Institutional Cohort Study (1959-2013).
Academic Article	MiRNA-20b/SUFU/Wnt axis accelerates gastric cancer cell proliferation, migration and EMT.
Academic Article	Saffron and Its Major Ingredients' Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite Instability.
Academic Article	Integrating microbiomics in cancer management.
Academic Article	Hyperactivation of MEK/ERK pathway by Ca2+ /calmodulin-dependent protein kinase kinase 2?promotes cellular proliferation by activating cyclin-dependent kinases?and minichromosome maintenance protein?in gastric cancer cells.
Academic Article	PIWI interacting RNAs perspectives: a new avenues in future cancer investigations.
Academic Article	Colorectal cancer subtyping.
Academic Article	A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/?-catenin signaling pathway to promote gastric cancer progression.
Academic Article	Vimentin binds to a novel tumor suppressor protein, GSPT1-238aa, encoded by circGSPT1 with a selective encoding priority to halt autophagy in gastric carcinoma.
Academic Article	The scaffolding protein flot2 promotes cytoneme-based transport of wnt3 in gastric cancer.
Academic Article	Predictors of Mortality in Hospitalized African American Covid-19 Cancer Patients.
Academic Article	Inflammation, microbiome and colorectal cancer disparity in African-Americans: Are there bugs in the genetics?
Academic Article	Saffron, Its Active Components, and Their Association with DNA and Histone Modification: A Narrative Review of Current Knowledge.
Academic Article	Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer.
Grant	Inactivation of MSH3 in Colorectal Cancer and Race
Academic Article	Correction: Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer.
Academic Article	Comprehensive molecular phenotyping of ARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities.
Academic Article	High-throughput sequencing and in-silico analysis confirm pathogenicity of novel MSH3 variants in African American colorectal cancer.
Academic Article	IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing.
Academic Article	Ceramide promotes lytic reactivation of Epstein-Barr virus in gastric carcinoma.
Academic Article	Mechanism of Antitumor Effects of Saffron in Human Prostate Cancer Cells.
Academic Article	Circulating Nucleic Acids in Colorectal Cancer: Diagnostic and Prognostic Value.
Academic Article	Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression.
Academic Article	Kinesin family member B18 is related to gastric mucin phenotype and contributes to gastric cancer progression by regulating epithelial-mesenchymal transition.
Academic Article	Retraction Note: Lymphatic metastasis-related TBL1XR1 enhances stemness and metastasis in gastric cancer stem-like cells by activating ERK1/2-SOX2 signaling.

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Neoplasms