DEAD-box RNA Helicases

"DEAD-box RNA Helicases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A large family of RNA helicases that share a common protein motif with the single letter amino acid sequence D-E-A-D (Asp-Glu-Ala-Asp). In addition to RNA helicase activity, members of the DEAD-box family participate in other aspects of RNA metabolism and regulation of RNA function.

Descriptor ID	D053487
MeSH Number(s)	D08.811.913.696.445.735.720.249
Concept/Terms	DEAD-box RNA Helicases DEAD-box RNA Helicases DEAD box RNA Helicases Helicases, DEAD-box RNA RNA Helicases, DEAD-box DEAD Box Helicase p68 DEAD Box Helicase p68 p68 RNA Helicase Helicase, p68 RNA RNA Helicase, p68 p68 DEAD Box Protein

Below are MeSH descriptors whose meaning is more general than "DEAD-box RNA Helicases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Nucleotidyltransferases [D08.811.913.696.445]
RNA Nucleotidyltransferases [D08.811.913.696.445.735]
RNA Helicases [D08.811.913.696.445.735.720]
DEAD-box RNA Helicases [D08.811.913.696.445.735.720.249]

Below are MeSH descriptors whose meaning is related to "DEAD-box RNA Helicases".

Below are MeSH descriptors whose meaning is more specific than "DEAD-box RNA Helicases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DEAD-box RNA Helicases" by people in this website by year, and whether "DEAD-box RNA Helicases" was a major or minor topic of these publications.

Bar chart showing 15 publications over 12 distinct years, with a maximum of 2 publications in 2023 and 2024 and 2025

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	0	1	1
2009	0	1	1
2011	1	0	1
2012	1	0	1
2013	1	0	1
2014	0	1	1
2015	0	1	1
2018	1	0	1
2021	1	0	1
2023	0	2	2
2024	0	2	2
2025	2	0	2

Below are the most recent publications written about "DEAD-box RNA Helicases" by people in Profiles.

Daniels MH, Castro J, Lee YT, Gotur D, Knockenhauer KE, Grigoriu S, Lockbaum GJ, Cheong JE, Lu C, Brennan D, Buker SM, Liu J, Yao S, Sparling BA, Sickmier EA, Ribich S, Blakemore SJ, Silver SJ, Boriack-Sjodin PA, Duncan KW, Copeland RA. Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9. J Med Chem. 2025 May 08; 68(9):9537-9554.

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Castro J, Daniels MH, Brennan D, Johnston B, Gotur D, Lee YT, Knockenhauer KE, Lu C, Wu J, Nayak S, Collins C, Bansal R, Buker SM, Case A, Liu J, Yao S, Sparling BA, Sickmier EA, Silver SJ, Blakemore SJ, Boriack-Sjodin PA, Duncan KW, Ribich S, Copeland RA. A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair. Cancer Res. 2025 Feb 17; 85(4):758-776.

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Milano SN, Bayer LV, Ko JJ, Casella CE, Bratu DP. The role of ER exit sites in maintaining P-body organization and integrity during Drosophila melanogaster oogenesis. EMBO Rep. 2025 Jan; 26(2):494-520.

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Tseng AC, Nerurkar VR, Neupane KR, Kae H, Kaufusi PH. Membrane Retention of West Nile Virus NS5 Depends on NS1 or NS3 for Enzymatic Activity. Viruses. 2024 08 16; 16(8).

View in: PubMed
Narayan G, Gracia Mazuca LA, Cho SS, Mohl JE, Koculi E. RNA Post-transcriptional Modifications of an Early-Stage Large-Subunit Ribosomal Intermediate. Biochemistry. 2023 10 17; 62(20):2908-2915.

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Xiang Y, Huang W, Tan L, Chen T, He Y, Irving PS, Weeks KM, Zhang QC, Dong X. Pervasive downstream RNA hairpins dynamically dictate start-codon selection. Nature. 2023 09; 621(7978):423-430.

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Luo QJ, Zhang J, Li P, Wang Q, Zhang Y, Roy-Chaudhuri B, Xu J, Kay MA, Zhang QC. RNA structure probing reveals the structural basis of Dicer binding and cleavage. Nat Commun. 2021 06 07; 12(1):3397.

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Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang QC, Wang HW. Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell. 2018 05 17; 173(5):1191-1203.e12.

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Walter JE, Rosen LB, Csomos K, Rosenberg JM, Mathew D, Keszei M, Ujhazi B, Chen K, Lee YN, Tirosh I, Dobbs K, Al-Herz W, Cowan MJ, Puck J, Bleesing JJ, Grimley MS, Malech H, De Ravin SS, Gennery AR, Abraham RS, Joshi AY, Boyce TG, Butte MJ, Nadeau KC, Balboni I, Sullivan KE, Akhter J, Adeli M, El-Feky RA, El-Ghoneimy DH, Dbaibo G, Wakim R, Azzari C, Palma P, Cancrini C, Capuder K, Condino-Neto A, Costa-Carvalho BT, Oliveira JB, Roifman C, Buchbinder D, Kumanovics A, Franco JL, Niehues T, Schuetz C, Kuijpers T, Yee C, Chou J, Masaad MJ, Geha R, Uzel G, Gelman R, Holland SM, Recher M, Utz PJ, Browne SK, Notarangelo LD. Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J Clin Invest. 2015 Nov 02; 125(11):4135-48.

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Rupaimoole R, Wu SY, Pradeep S, Ivan C, Pecot CV, Gharpure KM, Nagaraja AS, Armaiz-Pena GN, McGuire M, Zand B, Dalton HJ, Filant J, Miller JB, Lu C, Sadaoui NC, Mangala LS, Taylor M, van den Beucken T, Koch E, Rodriguez-Aguayo C, Huang L, Bar-Eli M, Wouters BG, Radovich M, Ivan M, Calin GA, Zhang W, Lopez-Berestein G, Sood AK. Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression. Nat Commun. 2014 Oct 29; 5:5202.

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