A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.

Descriptor ID	D053473
MeSH Number(s)	D12.644.360.024.131.500 D12.644.360.024.313.500 D12.644.360.075.358.500 D12.644.360.539.500.500 D12.776.157.057.006.500 D12.776.157.057.078.500 D12.776.476.024.139.500 D12.776.476.024.391.500 D12.776.476.075.358.500
Concept/Terms	Nod2 Signaling Adaptor Protein Nod2 Signaling Adaptor Protein CARD15 Protein Nucleotide Oligomerization Domain 2 Protein Caspase Recruitment Domain Protein 15

Below are MeSH descriptors whose meaning is more general than "Nod2 Signaling Adaptor Protein".

Below are MeSH descriptors whose meaning is related to "Nod2 Signaling Adaptor Protein".

Below are MeSH descriptors whose meaning is more specific than "Nod2 Signaling Adaptor Protein".