"Serum Response Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A MADS domain-containing transcription factor that binds to the SERUM RESPONSE ELEMENT in the promoter-enhancer region of many genes. It is one of the four founder proteins that structurally define the superfamily of MADS DOMAIN PROTEINS.
| Descriptor ID |
D026362
|
| MeSH Number(s) |
D12.776.260.400.249.875 D12.776.930.397.875
|
| Concept/Terms |
Serum Response Factor- Serum Response Factor
- Response Factor, Serum
- Transcription Factor SRF
- c-fos Serum Response Factor
- c fos Serum Response Factor
|
Below are MeSH descriptors whose meaning is more general than "Serum Response Factor".
Below are MeSH descriptors whose meaning is more specific than "Serum Response Factor".
This graph shows the total number of publications written about "Serum Response Factor" by people in this website by year, and whether "Serum Response Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Serum Response Factor" by people in Profiles.
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Knipe RS, Nurunnabi M, Probst CK, Spinney JJ, Abe E, Bose RJC, Ha K, Logue A, Nguyen T, Servis R, Drummond M, Haring A, Brazee PL, Medoff BD, McCarthy JR. Myofibroblast-specific inhibition of the Rho kinase-MRTF-SRF pathway using nanotechnology for the prevention of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2023 02 01; 324(2):L190-L198.
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Newaz M, Yousefipour Z. Acrolein-induced inflammatory signaling in vascular smooth muscle cells requires activation of serum response factor (SRF) and NF?B. J Basic Clin Physiol Pharmacol. 2013; 24(4):287-97.
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Koike MA, Lin AJ, Pham J, Nguyen E, Yeh JJ, Rahimian R, Tromberg BJ, Choi B, Green KN, LaFerla FM. APP knockout mice experience acute mortality as the result of ischemia. PLoS One. 2012; 7(8):e42665.
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Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, Yezdani M, Reddy ES, Rao VN. c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. Oncogene. 2001 Mar 15; 20(11):1357-67.
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Chaudhary J, Skinner MK. Basic helix-loop-helix proteins can act at the E-box within the serum response element of the c-fos promoter to influence hormone-induced promoter activation in Sertoli cells. Mol Endocrinol. 1999 May; 13(5):774-86.
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Rao VN, Reddy ES. Delta elk-1, a variant of elk-1, fails to interact with the serum response factor and binds to DNA with modulated specificity. Cancer Res. 1993 Jan 15; 53(2):215-20.
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Rao VN, Reddy ES. elk-1 domains responsible for autonomous DNA binding, SRE:SRF interaction and negative regulation of DNA binding. Oncogene. 1992 Nov; 7(11):2335-40.