Guanine Nucleotide Exchange Factors

"Guanine Nucleotide Exchange Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.

Descriptor ID	D020662
MeSH Number(s)	D12.644.360.325.300 D12.776.476.325.300
Concept/Terms	Guanine Nucleotide Exchange Factors Guanine Nucleotide Exchange Factors Guanine-Nucleotide-Releasing Factor Guanine Nucleotide Releasing Factor GDP Dissociation Factor GDP-GTP Exchange Protein GDP GTP Exchange Protein GDP Dissociation Stimulators GDP-GTP Reversing Factors Factors, GDP-GTP Reversing GDP GTP Reversing Factors Reversing Factors, GDP-GTP Guanine Nucleotide Releasing Factors GDP Exchange Factors Exchange Factors, GDP Factors, GDP Exchange Guanine Nucleotide Exchange Factor

Below are MeSH descriptors whose meaning is more general than "Guanine Nucleotide Exchange Factors".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
GTP-Binding Protein Regulators [D12.644.360.325]
Guanine Nucleotide Exchange Factors [D12.644.360.325.300]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
GTP-Binding Protein Regulators [D12.776.476.325]
Guanine Nucleotide Exchange Factors [D12.776.476.325.300]

Below are MeSH descriptors whose meaning is related to "Guanine Nucleotide Exchange Factors".

Below are MeSH descriptors whose meaning is more specific than "Guanine Nucleotide Exchange Factors".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Guanine Nucleotide Exchange Factors" by people in this website by year, and whether "Guanine Nucleotide Exchange Factors" was a major or minor topic of these publications.

Bar chart showing 26 publications over 17 distinct years, with a maximum of 3 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
2001	1	0	1
2002	1	0	1
2003	1	2	3
2004	0	1	1
2005	2	0	2
2007	0	1	1
2010	1	0	1
2011	2	0	2
2012	1	1	2
2013	1	1	2
2014	2	0	2
2016	1	1	2
2017	0	1	1
2018	1	0	1
2022	0	2	2
2023	1	0	1

Below are the most recent publications written about "Guanine Nucleotide Exchange Factors" by people in Profiles.

Slika H, Mansour H, Nasser SA, Shaito A, Kobeissy F, Orekhov AN, Pintus G, Eid AH. Epac as a tractable therapeutic target. Eur J Pharmacol. 2023 Apr 15; 945:175645.

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Medina JI, Cruz-Collazo A, Del Mar Maldonado M, Gascot TM, Borrero-Garcia LD, Cooke M, Kazanietz MG, O'Farril EH, Vlaar CP, Dharmawardhane S. Characterization of Novel Derivatives of MBQ-167, an inhibitor of the GTP-binding proteins Rac/Cdc42. Cancer Res Commun. 2022 12; 2(12):1711-1726.

View in: PubMed
Durkee-Shock J, Zhang A, Liang H, Wright H, Magnusson J, Garabedian E, Marsh RA, Sullivan KE, Keller MD. Morbidity, Mortality, and Therapeutics in Combined Immunodeficiency: Data From the USIDNET Registry. J Allergy Clin Immunol Pract. 2022 05; 10(5):1334-1341.e6.

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Bao X, Liu H, Liu X, Ruan K, Zhang Y, Zhang Z, Hu Q, Liu Y, Akram S, Zhang J, Gong Q, Wang W, Yuan X, Li J, Zhao L, Dou Z, Tian R, Yao X, Wu J, Shi Y. Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation. J Mol Cell Biol. 2018 02 01; 10(1):18-32.

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Fan R, Enkhjargal B, Camara R, Yan F, Gong L, Tang J, Chen Y, Zhang JH. Critical role of EphA4 in early brain injury after subarachnoid hemorrhage in rat. Exp Neurol. 2017 10; 296:41-48.

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Wang BD, Ceniccola K, Hwang S, Andrawis R, Horvath A, Freedman JA, Olender J, Knapp S, Ching T, Garmire L, Patel V, Garcia-Blanco MA, Patierno SR, Lee NH. Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer. Nat Commun. 2017 06 30; 8:15921.

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Wilson JM, Prokop JW, Lorimer E, Ntantie E, Williams CL. Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B. J Mol Biol. 2016 12 04; 428(24 Pt B):4929-4945.

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B?ez-Vega PM, Echevarr?a Vargas IM, Valiyeva F, Encarnaci?n-Rosado J, Roman A, Flores J, Marcos-Mart?nez MJ, Vivas-Mej?a PE. Targeting miR-21-3p inhibits proliferation and invasion of ovarian cancer cells. Oncotarget. 2016 Jun 14; 7(24):36321-36337.

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Tehrani N, Del Rosario J, Dominguez M, Kalb R, Mano I. The insulin/IGF signaling regulators cytohesin/GRP-1 and PIP5K/PPK-1 modulate susceptibility to excitotoxicity in C. elegans. PLoS One. 2014; 9(11):e113060.

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Sharma A, Fonseca LL, Rajani C, Yanagida JK, Endo Y, Cline JM, Stone JC, Ji J, Ramos JW, Lorenzo PS. Targeted deletion of RasGRP1 impairs skin tumorigenesis. Carcinogenesis. 2014 May; 35(5):1084-91.

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