"Guanidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
| Descriptor ID |
D019791
|
| MeSH Number(s) |
D02.078.370.472
|
| Concept/Terms |
Guanidine Hydrochloride- Guanidine Hydrochloride
- Hydrochloride, Guanidine
- Guanidinium Chloride
- Chloride, Guanidinium
- Guanidium Chloride
- Chloride, Guanidium
- Guanidine Monohydrochloride
- Monohydrochloride, Guanidine
|
Below are MeSH descriptors whose meaning is more general than "Guanidine".
Below are MeSH descriptors whose meaning is more specific than "Guanidine".
This graph shows the total number of publications written about "Guanidine" by people in this website by year, and whether "Guanidine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 1 | 2 |
| 1998 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Guanidine" by people in Profiles.
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Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN. A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. ACS Chem Biol. 2019 06 21; 14(6):1183-1194.
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Baker MR, Li QX. Guanidination of tryptic peptides without desalting for matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry analysis. Anal Chem. 2013 Sep 17; 85(18):8873-80.
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Xu G, Narayan M, Welker E, Scheraga HA. Characterization of the fast-forming intermediate, des [30-75], in the reductive unfolding of onconase. Biochemistry. 2004 Mar 23; 43(11):3246-54.
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S?nchez SA, Brunet JE, Jameson DM, Lagos R, Monasterio O. Tubulin equilibrium unfolding followed by time-resolved fluorescence and fluorescence correlation spectroscopy. Protein Sci. 2004 Jan; 13(1):81-8.
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Narayan M, Welker E, Wanjalla C, Xu G, Scheraga HA. Shifting the competition between the intramolecular Reshuffling reaction and the direct oxidation reaction during the oxidative folding of kinetically trapped disulfide-insecure intermediates. Biochemistry. 2003 Sep 16; 42(36):10783-9.
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Narayan M, Welker E, Scheraga HA. Characterizing the unstructured intermediates in oxidative folding. Biochemistry. 2003 Jun 17; 42(23):6947-55.
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Louis JM, Georgescu RE, Tasayco ML, Tcherkasskaya O, Gronenborn AM. Probing the structure and stability of a hybrid protein: the human-E. coli thioredoxin chimera. Biochemistry. 2001 Sep 18; 40(37):11184-92.
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Bishop SM, Ross JB, Kohanski RA. Autophosphorylation dependent destabilization of the insulin receptor kinase domain: tryptophan-1175 reports changes in the catalytic cleft. Biochemistry. 1999 Mar 09; 38(10):3079-89.
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Nugent CI, Johnson KL, Sarnow P, Kirkegaard K. Functional coupling between replication and packaging of poliovirus replicon RNA. J Virol. 1999 Jan; 73(1):427-35.
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Georgescu RE, Li JH, Goldberg ME, Tasayco ML, Chaffotte AF. Proline isomerization-independent accumulation of an early intermediate and heterogeneity of the folding pathways of a mixed alpha/beta protein, Escherichia coli thioredoxin. Biochemistry. 1998 Jul 14; 37(28):10286-97.