Tight Junctions

"Tight Junctions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cell-cell junctions that seal adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. (Alberts et al., Molecular Biology of the Cell, 2nd ed, p22)

Descriptor ID	D019108
MeSH Number(s)	A11.284.149.165.420.820
Concept/Terms	Tight Junctions Tight Junctions Junction, Tight Junctions, Tight Tight Junction Zonula Occludens Occluden, Zonula Occludens, Zonula Zonula Occluden Occluding Junctions Junction, Occluding Junctions, Occluding Occluding Junction

Below are MeSH descriptors whose meaning is more general than "Tight Junctions".

Anatomy [A]
Cells [A11]
Cellular Structures [A11.284]
Cell Membrane [A11.284.149]
Cell Membrane Structures [A11.284.149.165]
Intercellular Junctions [A11.284.149.165.420]
Tight Junctions [A11.284.149.165.420.820]

Below are MeSH descriptors whose meaning is related to "Tight Junctions".

Below are MeSH descriptors whose meaning is more specific than "Tight Junctions".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tight Junctions" by people in this website by year, and whether "Tight Junctions" was a major or minor topic of these publications.

Bar chart showing 21 publications over 14 distinct years, with a maximum of 3 publications in 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2007	0	1	1
2008	1	0	1
2009	2	1	3
2010	0	2	2
2011	1	1	2
2012	1	1	2
2013	1	0	1
2014	0	1	1
2016	0	1	1
2018	1	0	1
2019	0	2	2
2020	0	1	1
2021	0	2	2

Below are the most recent publications written about "Tight Junctions" by people in Profiles.

Bony BA, Tarudji AW, Miller HA, Gowrikumar S, Roy S, Curtis ET, Gee CC, Vecchio A, Dhawan P, Kievit FM. Claudin-1-Targeted Nanoparticles for Delivery to Aging-Induced Alterations in the Blood-Brain Barrier. ACS Nano. 2021 Nov 23; 15(11):18520-18531.

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Wang B, Qian JY, Tang TT, Lin LL, Yu N, Guo HL, Ni WJ, Lv LL, Wen Y, Li ZL, Wu M, Cao JY, Liu BC. VDR/Atg3 Axis Regulates Slit Diaphragm to Tight Junction Transition via p62-Mediated Autophagy Pathway in Diabetic Nephropathy. Diabetes. 2021 11; 70(11):2639-2651.

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Nahid MA, Campbell CE, Fong KSK, Barnhill JC, Washington MA. An evaluation of the impact of clinical bacterial isolates on epithelial cell monolayer integrity by the electric Cell-Substrate Impedance Sensing (ECIS) method. J Microbiol Methods. 2020 02; 169:105833.

View in: PubMed
Ruffner MA, Song L, Maurer K, Shi L, Carroll MC, Wang JX, Muir AB, Spergel JM, Sullivan KE. Toll-like receptor 2 stimulation augments esophageal barrier integrity. Allergy. 2019 12; 74(12):2449-2460.

View in: PubMed
Stone NE, Nunnally AE, Jimenez V, Cope EK, Sahl JW, Sheridan K, Hornstra HM, Vinocur J, Settles EW, Headley KC, Williamson CHD, Rideout JR, Bolyen E, Caporaso JG, Terriquez J, Monroy FP, Busch JD, Keim P, Wagner DM. Domestic canines do not display evidence of gut microbial dysbiosis in the presence of Clostridioides (Clostridium) difficile, despite cellular susceptibility to its toxins. Anaerobe. 2019 Aug; 58:53-72.

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Manda B, Mir H, Gangwar R, Meena AS, Amin S, Shukla PK, Dalal K, Suzuki T, Rao R. Phosphorylation hotspot in the C-terminal domain of occludin regulates the dynamics of epithelial junctional complexes. J Cell Sci. 2018 04 06; 131(7).

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Kumar M, Nerurkar VR. In Vitro and In Vivo Blood-Brain Barrier Models to Study West Nile Virus Pathogenesis. Methods Mol Biol. 2016; 1435:103-13.

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Reaves DK, Fagan-Solis KD, Dunphy K, Oliver SD, Scott DW, Fleming JM. The role of lipolysis stimulated lipoprotein receptor in breast cancer and directing breast cancer cell behavior. PLoS One. 2014; 9(3):e91747.

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Chen H, Hu Y, Fang Y, Djukic Z, Yamamoto M, Shaheen NJ, Orlando RC, Chen X. Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Gut. 2014 May; 63(5):711-9.

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Vaziri ND, Yuan J, Norris K. Role of urea in intestinal barrier dysfunction and disruption of epithelial tight junction in chronic kidney disease. Am J Nephrol. 2013; 37(1):1-6.

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