"Dopamine Antagonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
| Descriptor ID |
D018492
|
| MeSH Number(s) |
D27.505.519.625.150.175 D27.505.696.577.150.175
|
| Concept/Terms |
Dopamine Antagonists- Dopamine Antagonists
- Dopaminergic Antagonists
- Dopamine Blockers
- Blockers, Dopamine
- Antagonists, Dopamine Receptor
- Receptor Antagonists, Dopamine
- Antagonists, Dopaminergic
- Dopamine Receptor Antagonists
- Antagonists, Dopamine
|
Below are MeSH descriptors whose meaning is more general than "Dopamine Antagonists".
Below are MeSH descriptors whose meaning is more specific than "Dopamine Antagonists".
This graph shows the total number of publications written about "Dopamine Antagonists" by people in this website by year, and whether "Dopamine Antagonists" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1998 | 1 | 1 | 2 |
| 2000 | 0 | 1 | 1 |
| 2004 | 1 | 2 | 3 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 4 | 4 |
| 2008 | 0 | 2 | 2 |
| 2010 | 0 | 3 | 3 |
| 2011 | 0 | 1 | 1 |
| 2014 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 1 | 3 |
| 2020 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Dopamine Antagonists" by people in Profiles.
-
Giri R, Namballa HK, Emogaje V, Harding WW. Structure-Activity Relationship Studies on 6-Chloro-1-phenylbenzazepines Leads to the Identification of a New Dopamine D1 Receptor Antagonist. Molecules. 2023 Aug 11; 28(16).
-
Bennett A, Barrera E, Namballa H, Harding W, Ranaldi R. (-)-Stepholidine blocks expression, but not development, of cocaine conditioned place preference in rats. Neurosci Lett. 2020 08 24; 734:135151.
-
Giri R, Namballa HK, Sarker A, Alberts I, Harding WW. Synthesis and dopamine receptor pharmacological evaluations on ring C ortho halogenated 1-phenylbenzazepines. Bioorg Med Chem Lett. 2020 08 15; 30(16):127305.
-
Pal RK, Gadhiya S, Ramsey S, Cordone P, Wickstrom L, Harding WW, Kurtzman T, Gallicchio E. Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes. PLoS One. 2019; 14(9):e0222902.
-
Maguire GA, LaSalle L, Hoffmeyer D, Nelson M, Lochhead JD, Davis K, Burris A, Yaruss JS. Ecopipam as a pharmacologic treatment of stuttering. Ann Clin Psychiatry. 2019 08; 31(3):164-168.
-
Manvich DF, Petko AK, Branco RC, Foster SL, Porter-Stransky KA, Stout KA, Newman AH, Miller GW, Paladini CA, Weinshenker D. Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens. Neuropsychopharmacology. 2019 07; 44(8):1445-1455.
-
Manuszak M, Harding W, Gadhiya S, Ranaldi R. (-)-Stepholidine reduces cue-induced reinstatement of cocaine seeking and cocaine self-administration in rats. Drug Alcohol Depend. 2018 08 01; 189:49-54.
-
Galaj E, Harding W, Ranaldi R. Dopamine D1 and D3 receptor interactions in cocaine reward and seeking in rats. Psychopharmacology (Berl). 2016 Dec; 233(23-24):3881-3890.
-
Sampson D, Zhu XY, Eyunni SV, Etukala JR, Ofori E, Bricker B, Lamango NS, Setola V, Roth BL, Ablordeppey SY. Identification of a new selective dopamine D4 receptor ligand. Bioorg Med Chem. 2014 Jun 15; 22(12):3105-14.
-
Vallejo D, Habib MR, Delgado N, Vaasjo LO, Croll RP, Miller MW. Localization of tyrosine hydroxylase-like immunoreactivity in the nervous systems of Biomphalaria glabrata and Biomphalaria alexandrina, intermediate hosts for schistosomiasis. J Comp Neurol. 2014 Aug 01; 522(11):2532-52.