"Superantigens" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
| Descriptor ID |
D018089
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| MeSH Number(s) |
D23.050.820
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Superantigens".
Below are MeSH descriptors whose meaning is more specific than "Superantigens".
This graph shows the total number of publications written about "Superantigens" by people in this website by year, and whether "Superantigens" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Superantigens" by people in Profiles.
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Eppinger M, Rosovitz MJ, Fricke WF, Rasko DA, Kokorina G, Fayolle C, Lindler LE, Carniel E, Ravel J. The complete genome sequence of Yersinia pseudotuberculosis IP31758, the causative agent of Far East scarlet-like fever. PLoS Genet. 2007 Aug; 3(8):e142.
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Mondal TK, Bhatta D, Ray PK, Pal P. Synergistic immunopotentiating effects induced by T-cell and B-cell superantigen in mice. Immunol Invest. 2001 Aug; 30(3):169-80.