Alternative Splicing

"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.

Descriptor ID	D017398
MeSH Number(s)	G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
Concept/Terms	Alternative Splicing Alternative Splicing Alternative Splicings Splicings, Alternative Alternate Splicing Alternate Splicings Splicing, Alternate Splicings, Alternate RNA Splicing, Alternative Alternative RNA Splicing Alternative RNA Splicings RNA Splicings, Alternative Splicing, Alternative RNA Splicings, Alternative RNA Splicing, Alternative Nested Transcripts Nested Transcripts Nested Transcript Transcript, Nested Transcripts, Nested

Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
RNA Processing, Post-Transcriptional [G02.111.760]
RNA Splicing [G02.111.760.700]
Alternative Splicing [G02.111.760.700.100]
Metabolism [G03]
RNA Processing, Post-Transcriptional [G03.839]
RNA Splicing [G03.839.700]
Alternative Splicing [G03.839.700.100]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
RNA Processing, Post-Transcriptional [G05.308.700]
RNA Splicing [G05.308.700.700]
Alternative Splicing [G05.308.700.700.100]

Below are MeSH descriptors whose meaning is related to "Alternative Splicing".

Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.

Bar chart showing 65 publications over 25 distinct years, with a maximum of 6 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1998	3	0	3
1999	2	2	4
2000	1	0	1
2001	2	1	3
2002	0	1	1
2003	1	1	2
2004	1	2	3
2005	0	4	4
2006	1	0	1
2007	0	2	2
2009	0	3	3
2010	1	2	3
2011	1	1	2
2012	2	4	6
2013	2	1	3
2014	1	2	3
2015	0	1	1
2016	1	4	5
2017	1	2	3
2018	1	2	3
2019	0	2	2
2021	1	1	2
2022	0	2	2
2023	2	0	2

Below are the most recent publications written about "Alternative Splicing" by people in Profiles.

Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L. Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nat Commun. 2023 Nov 25; 14(1):7732.

View in: PubMed
Acu?a ML, Garc?a-Morin A, Orozco-Sep?lveda R, Ontiveros C, Flores A, Diaz AV, Guti?rrez-Zubiate I, Patil AR, Alvarado LA, Roy S, Russell WK, Rosas-Acosta G. Alternative splicing of the SUMO1/2/3 transcripts affects cellular SUMOylation and produces functionally distinct SUMO protein isoforms. Sci Rep. 2023 02 09; 13(1):2309.

View in: PubMed
Zhang R, Kuo R, Coulter M, Calixto CPG, Entizne JC, Guo W, Marquez Y, Milne L, Riegler S, Matsui A, Tanaka M, Harvey S, Gao Y, Wie?ner-Kroh T, Paniagua A, Crespi M, Denby K, Hur AB, Huq E, Jantsch M, Jarmolowski A, Koester T, Laubinger S, Li QQ, Gu L, Seki M, Staiger D, Sunkar R, Szweykowska-Kulinska Z, Tu SL, Wachter A, Waugh R, Xiong L, Zhang XN, Conesa A, Reddy ASN, Barta A, Kalyna M, Brown JWS. A high-resolution single-molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis. Genome Biol. 2022 07 07; 23(1):149.

View in: PubMed
Hardwick SA, Hu W, Joglekar A, Fan L, Collier PG, Foord C, Balacco J, Lanjewar S, Sampson MM, Koopmans F, Prjibelski AD, Mikheenko A, Belchikov N, Jarroux J, Lucas AB, Palkovits M, Luo W, Milner TA, Ndhlovu LC, Smit AB, Trojanowski JQ, Lee VMY, Fedrigo O, Sloan SA, Tomb?cz D, Ross ME, Jarvis E, Boldogkoi Z, Gan L, Tilgner HU. Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue. Nat Biotechnol. 2022 07; 40(7):1082-1092.

View in: PubMed
Williams AL, Walton CB, Pinell B, Khadka VS, Dunn B, Lee K, Anagaran MCT, Avelar A, Shohet RV. Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2?. Sci Rep. 2021 06 23; 11(1):13116.

View in: PubMed
Zhang YZ, Lin J, Ren Z, Chen CX, Miki D, Xie SS, Zhang J, Chang YN, Jiang J, Yan J, Li QQ, Zhu JK, Duan CG. Genome-wide distribution and functions of the AAE complex in epigenetic regulation in Arabidopsis. J Integr Plant Biol. 2021 Apr; 63(4):707-722.

View in: PubMed
Krokhotin A, Sarker M, Sevilla EA, Costantini LM, Griffith JD, Campbell SL, Dokholyan NV. Distinct Binding Modes of Vinculin Isoforms Underlie Their Functional Differences. Structure. 2019 10 01; 27(10):1527-1536.e3.

View in: PubMed
Olender J, Wang BD, Ching T, Garmire LX, Garofano K, Ji Y, Knox T, Latham P, Nguyen K, Rhim J, Lee NH. A Novel FGFR3 Splice Variant Preferentially Expressed in African American Prostate Cancer Drives Aggressive Phenotypes and Docetaxel Resistance. Mol Cancer Res. 2019 10; 17(10):2115-2125.

View in: PubMed
Fedoriw A, Rajapurkar SR, O'Brien S, Gerhart SV, Mitchell LH, Adams ND, Rioux N, Lingaraj T, Ribich SA, Pappalardi MB, Shah N, Laraio J, Liu Y, Butticello M, Carpenter CL, Creasy C, Korenchuk S, McCabe MT, McHugh CF, Nagarajan R, Wagner C, Zappacosta F, Annan R, Concha NO, Thomas RA, Hart TK, Smith JJ, Copeland RA, Moyer MP, Campbell J, Stickland K, Mills J, Jacques-O'Hagan S, Allain C, Johnston D, Raimondi A, Porter Scott M, Waters N, Swinger K, Boriack-Sjodin A, Riera T, Shapiro G, Chesworth R, Prinjha RK, Kruger RG, Barbash O, Mohammad HP. Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss. Cancer Cell. 2019 07 08; 36(1):100-114.e25.

View in: PubMed
He KY, Li X, Kelly TN, Liang J, Cade BE, Assimes TL, Becker LC, Beitelshees AL, Bress AP, Chang YC, Chen YI, de Vries PS, Fox ER, Franceschini N, Furniss A, Gao Y, Guo X, Haessler J, Hwang SJ, Irvin MR, Kalyani RR, Liu CT, Liu C, Martin LW, Montasser ME, Muntner PM, Mwasongwe S, Palmas W, Reiner AP, Shimbo D, Smith JA, Snively BM, Yanek LR, Boerwinkle E, Correa A, Cupples LA, He J, Kardia SLR, Kooperberg C, Mathias RA, Mitchell BD, Psaty BM, Vasan RS, Rao DC, Rich SS, Rotter JI, Wilson JG, Chakravarti A, Morrison AC, Levy D, Arnett DK, Redline S, Zhu X. Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data. Hum Genet. 2019 Feb; 138(2):199-210.

View in: PubMed

People

Explore

Similar Concepts

Top Journals