Alternative Splicing

"Alternative Splicing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.

Descriptor ID	D017398
MeSH Number(s)	G02.111.760.700.100 G03.839.700.100 G05.308.700.700.100
Concept/Terms	Alternative Splicing Alternative Splicing Alternative Splicings Splicings, Alternative Alternate Splicing Alternate Splicings Splicing, Alternate Splicings, Alternate RNA Splicing, Alternative Alternative RNA Splicing Alternative RNA Splicings RNA Splicings, Alternative Splicing, Alternative RNA Splicings, Alternative RNA Splicing, Alternative Nested Transcripts Nested Transcripts Nested Transcript Transcript, Nested Transcripts, Nested

Below are MeSH descriptors whose meaning is more general than "Alternative Splicing".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
RNA Processing, Post-Transcriptional [G02.111.760]
RNA Splicing [G02.111.760.700]
Alternative Splicing [G02.111.760.700.100]
Metabolism [G03]
RNA Processing, Post-Transcriptional [G03.839]
RNA Splicing [G03.839.700]
Alternative Splicing [G03.839.700.100]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
RNA Processing, Post-Transcriptional [G05.308.700]
RNA Splicing [G05.308.700.700]
Alternative Splicing [G05.308.700.700.100]

Below are MeSH descriptors whose meaning is related to "Alternative Splicing".

Below are MeSH descriptors whose meaning is more specific than "Alternative Splicing".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Alternative Splicing" by people in this website by year, and whether "Alternative Splicing" was a major or minor topic of these publications.

Bar chart showing 72 publications over 27 distinct years, with a maximum of 5 publications in 2009 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1998	3	0	3
1999	2	2	4
2000	1	0	1
2001	2	2	4
2002	0	2	2
2003	1	1	2
2004	1	2	3
2005	0	4	4
2006	1	0	1
2007	0	2	2
2009	1	4	5
2010	1	2	3
2011	1	1	2
2012	2	3	5
2013	2	1	3
2014	2	2	4
2015	0	1	1
2016	1	3	4
2017	1	2	3
2018	1	2	3
2019	0	2	2
2021	1	1	2
2022	0	2	2
2023	2	0	2
2024	0	1	1
2025	1	2	3

Below are the most recent publications written about "Alternative Splicing" by people in Profiles.

Hansen MS, Hill CJ, Sussel L, Wells KL. Optimizing Single-Cell Long-Read Sequencing for Enhanced Isoform Detection in Pancreatic Islets. Diabetes. 2026 Apr 01; 75(4):606-616.

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Xiong Z, Kong Q, Chagantipati B, Stepniak A, Jaswal AP, Sneiderman CT, Han Y, Jackson SA, Raphael RA, Zhang W, Li M, Chao Y, Qin B, Dulkadir Z, Schwegman L, Zhang Y, Kuminkoski C, Mahlke MA, Nath P, Hu B, Zinn PO, Mantica M, Agnihotri S, Nechemia-Arbely Y, Pollack IF, Rigatti LH, Forsthuber TG, Li X, Raphael I, Kohanbash G. C/EBP?-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastoma. Cell Mol Immunol. 2026 Jan; 23(1):94-113.

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Verma R, Bullinger KL, Pearson A, Dhakar M, Guven E, Amini E, Simon RP, Meller R. Differential Transcript Expression and Alternative RNA Splicing Patterns to Differentiate Focal vs. Generalized-Onset Seizures. Mol Neurobiol. 2025 Oct; 62(10):13303-13317.

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Xiong Z, Sneiderman CT, Kuminkoski CR, Reinheimer J, Schwegman L, Sever RE, Habib A, Hu B, Agnihotri S, Rajasundaram D, Zinn PO, Forsthuber TG, Pollack IF, Li X, Raphael I, Kohanbash G. Transcript-targeted antigen mapping reveals the potential of POSTN splicing junction epitopes in glioblastoma immunotherapy. Genes Immun. 2025 06; 26(3):190-199.

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Orozco-Sep?lveda R, Garc?a-Morin A, Guti?rrez-Zubiate I, Rosas-Acosta G. A Vivo-Morpholino-Based Approach to Block Paralog-Specific SUMOylation. Methods Mol Biol. 2025; 2957:191-206.

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Joglekar A, Hu W, Zhang B, Narykov O, Diekhans M, Marrocco J, Balacco J, Ndhlovu LC, Milner TA, Fedrigo O, Jarvis ED, Sheynkman G, Korkin D, Ross ME, Tilgner HU. Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain. Nat Neurosci. 2024 Jun; 27(6):1051-1063.

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Moss ND, Wells KL, Theis A, Kim YK, Spigelman AF, Liu X, MacDonald PE, Sussel L. Modulation of insulin secretion by RBFOX2-mediated alternative splicing. Nat Commun. 2023 11 25; 14(1):7732.

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Acu?a ML, Garc?a-Morin A, Orozco-Sep?lveda R, Ontiveros C, Flores A, Diaz AV, Guti?rrez-Zubiate I, Patil AR, Alvarado LA, Roy S, Russell WK, Rosas-Acosta G. Alternative splicing of the SUMO1/2/3 transcripts affects cellular SUMOylation and produces functionally distinct SUMO protein isoforms. Sci Rep. 2023 02 09; 13(1):2309.

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Zhang R, Kuo R, Coulter M, Calixto CPG, Entizne JC, Guo W, Marquez Y, Milne L, Riegler S, Matsui A, Tanaka M, Harvey S, Gao Y, Wie?ner-Kroh T, Paniagua A, Crespi M, Denby K, Hur AB, Huq E, Jantsch M, Jarmolowski A, Koester T, Laubinger S, Li QQ, Gu L, Seki M, Staiger D, Sunkar R, Szweykowska-Kulinska Z, Tu SL, Wachter A, Waugh R, Xiong L, Zhang XN, Conesa A, Reddy ASN, Barta A, Kalyna M, Brown JWS. A high-resolution single-molecule sequencing-based Arabidopsis transcriptome using novel methods of Iso-seq analysis. Genome Biol. 2022 07 07; 23(1):149.

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Hardwick SA, Hu W, Joglekar A, Fan L, Collier PG, Foord C, Balacco J, Lanjewar S, Sampson MM, Koopmans F, Prjibelski AD, Mikheenko A, Belchikov N, Jarroux J, Lucas AB, Palkovits M, Luo W, Milner TA, Ndhlovu LC, Smit AB, Trojanowski JQ, Lee VMY, Fedrigo O, Sloan SA, Tomb?cz D, Ross ME, Jarvis E, Boldogkoi Z, Gan L, Tilgner HU. Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue. Nat Biotechnol. 2022 07; 40(7):1082-1092.

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