Transforming Growth Factor alpha

"Transforming Growth Factor alpha" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.

Descriptor ID	D016211
MeSH Number(s)	D12.644.276.382.750 D12.644.276.963.360 D12.776.467.382.750 D12.776.467.960.360 D23.529.382.750 D23.529.960.360
Concept/Terms	Transforming Growth Factor alpha Transforming Growth Factor alpha TGF-alpha TGFalpha Epidermal Growth Factor-Related Transforming Growth Factor Epidermal Growth Factor Related Transforming Growth Factor

Below are MeSH descriptors whose meaning is more general than "Transforming Growth Factor alpha".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
EGF Family of Proteins [D12.644.276.382]
Transforming Growth Factor alpha [D12.644.276.382.750]
Transforming Growth Factors [D12.644.276.963]
Transforming Growth Factor alpha [D12.644.276.963.360]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
EGF Family of Proteins [D12.776.467.382]
Transforming Growth Factor alpha [D12.776.467.382.750]
Transforming Growth Factors [D12.776.467.960]
Transforming Growth Factor alpha [D12.776.467.960.360]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
EGF Family of Proteins [D23.529.382]
Transforming Growth Factor alpha [D23.529.382.750]
Transforming Growth Factors [D23.529.960]
Transforming Growth Factor alpha [D23.529.960.360]

Below are MeSH descriptors whose meaning is related to "Transforming Growth Factor alpha".

Below are MeSH descriptors whose meaning is more specific than "Transforming Growth Factor alpha".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transforming Growth Factor alpha" by people in this website by year, and whether "Transforming Growth Factor alpha" was a major or minor topic of these publications.

Bar chart showing 18 publications over 13 distinct years, with a maximum of 3 publications in 2008 and 2009

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
2003	1	0	1
2006	0	1	1
2007	0	2	2
2008	2	1	3
2009	2	1	3
2010	1	0	1
2012	1	0	1
2013	0	1	1
2014	1	0	1
2015	0	1	1
2016	1	0	1
2017	0	1	1

Below are the most recent publications written about "Transforming Growth Factor alpha" by people in Profiles.

Pajarillo E, Johnson J, Kim J, Karki P, Son DS, Aschner M, Lee E. 17?-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity. Neurotoxicology. 2018 03; 65:280-288.

View in: PubMed
Karki P, Johnson J, Son DS, Aschner M, Lee E. Transcriptional Regulation of Human Transforming Growth Factor-a in Astrocytes. Mol Neurobiol. 2017 03; 54(2):964-976.

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Liou GY, D?ppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun. 2015 Feb 20; 6:6200.

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Karki P, Smith K, Johnson J, Lee E. Astrocyte-derived growth factors and estrogen neuroprotection: role of transforming growth factor-a in estrogen-induced upregulation of glutamate transporters in astrocytes. Mol Cell Endocrinol. 2014 May 25; 389(1-2):58-64.

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Karki P, Webb A, Smith K, Lee K, Son DS, Aschner M, Lee E. cAMP response element-binding protein (CREB) and nuclear factor ?B mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes. J Biol Chem. 2013 Oct 04; 288(40):28975-86.

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Lee E, Sidoryk-Wegrzynowicz M, Yin Z, Webb A, Son DS, Aschner M. Transforming growth factor-a mediates estrogen-induced upregulation of glutamate transporter GLT-1 in rat primary astrocytes. Glia. 2012 Jul; 60(7):1024-36.

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Hoffmann P, Hoeck K, Deters S, Werner-Martini I, Schmidt WE. Substance P and calcitonin gene related peptide induce TGF-alpha expression in epithelial cells via mast cells and fibroblasts. Regul Pept. 2010 Apr 09; 161(1-3):33-7.

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Bulut K, Felderbauer P, Hoeck K, Schmidt WE, Hoffmann P. Carbachol induces TGF-alpha expression and colonic epithelial cell proliferation in sensory-desensitised rats. Int J Colorectal Dis. 2010 Mar; 25(3):335-41.

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Ge L, Baskic D, Basse P, Vujanovic L, Unlu S, Yoneyama T, Vujanovic A, Han J, Bankovic D, Szczepanski MJ, Hunt JL, Herberman RB, Gollin SM, Ferris RL, Whiteside TL, Myers EN, Vujanovic NL. Sheddase activity of tumor necrosis factor-alpha converting enzyme is increased and prognostically valuable in head and neck cancer. Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):2913-22.

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Mutsaers AJ, Francia G, Man S, Lee CR, Ebos JM, Wu Y, Witte L, Berry S, Moore M, Kerbel RS. Dose-dependent increases in circulating TGF-alpha and other EGFR ligands act as pharmacodynamic markers for optimal biological dosing of cetuximab and are tumor independent. Clin Cancer Res. 2009 Apr 01; 15(7):2397-405.

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