Epidermal Growth Factor

"Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.

Descriptor ID	D004815
MeSH Number(s)	D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500
Concept/Terms	Epidermal Growth Factor Epidermal Growth Factor Growth Factor, Epidermal Urogastrone Epidermal Growth Factor-Urogastrone Growth Factor-Urogastrone, Epidermal Human Urinary Gastric Inhibitor beta-Urogastrone beta Urogastrone EGF

Below are MeSH descriptors whose meaning is more general than "Epidermal Growth Factor".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Gastrointestinal Hormones [D06.472.317]
Epidermal Growth Factor [D06.472.317.350]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
EGF Family of Proteins [D12.644.276.382]
Epidermal Growth Factor [D12.644.276.382.500]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
EGF Family of Proteins [D12.776.467.382]
Epidermal Growth Factor [D12.776.467.382.500]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
EGF Family of Proteins [D23.529.382]
Epidermal Growth Factor [D23.529.382.500]

Below are MeSH descriptors whose meaning is related to "Epidermal Growth Factor".

Below are MeSH descriptors whose meaning is more specific than "Epidermal Growth Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epidermal Growth Factor" by people in this website by year, and whether "Epidermal Growth Factor" was a major or minor topic of these publications.

Bar chart showing 51 publications over 19 distinct years, with a maximum of 6 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1998	0	1	1
2001	1	0	1
2002	5	1	6
2003	1	1	2
2004	2	3	5
2005	0	2	2
2006	1	3	4
2007	0	4	4
2008	3	2	5
2009	0	2	2
2011	0	3	3
2012	1	3	4
2013	1	2	3
2015	1	1	2
2016	0	2	2
2018	0	2	2
2019	0	1	1
2020	0	1	1

Below are the most recent publications written about "Epidermal Growth Factor" by people in Profiles.

Venugopal SV, Caggia S, Gambrell-Sanders D, Khan SA. Differential roles and activation of mammalian target of rapamycin complexes 1 and 2 during cell migration in prostate cancer cells. Prostate. 2020 04; 80(5):412-423.

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Nava M, Dutta P, Zemke NR, Farias-Eisner R, Vadgama JV, Wu Y. Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets. BMC Med Genomics. 2019 02 08; 12(1):32.

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Caggia S, Chunduri H, Millena AC, Perkins JN, Venugopal SV, Vo BT, Li C, Tu Y, Khan SA. Novel role of Gia2 in cell migration: Downstream of PI3-kinase-AKT and Rac1 in prostate cancer cells. J Cell Physiol. 2018 01; 234(1):802-815.

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Abisoye-Ogunniyan A, Lin H, Ghebremedhin A, Salam AB, Karanam B, Theodore S, Jones-Trich J, Davis M, Grizzle W, Wang H, Yates C. Transcriptional repressor Kaiso promotes epithelial to mesenchymal transition and metastasis in prostate cancer through direct regulation of miR-200c. Cancer Lett. 2018 09 01; 431:1-10.

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Liou GY, D?ppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP, Storz P. Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. Cell Rep. 2016 Mar 15; 14(10):2325-36.

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Kawprasertsri S, Pietras RJ, Marquez-Garban DC, Boonyaratanakornkit V. Progesterone receptor (PR) polyproline domain (PPD) mediates inhibition of epidermal growth factor receptor (EGFR) signaling in non-small cell lung cancer cells. Cancer Lett. 2016 May 01; 374(2):279-91.

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Cao D, Su Z, Wang W, Wu H, Liu X, Akram S, Qin B, Zhou J, Zhuang X, Adams G, Jin C, Wang X, Liu L, Hill DL, Wang D, Ding X, Yao X. Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration. J Biol Chem. 2015 Sep 25; 290(39):23766-80.

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Park GH, Rhee do Y, Moon HR, Won CH, Lee MW, Choi JH, Moon KC, Chang SE. Effect of an epidermal growth factor-containing cream on postinflammatory hyperpigmentation after Q-switched 532-nm neodymium-doped yttrium aluminum garnet laser treatment. Dermatol Surg. 2015 Jan; 41(1):131-5.

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Hsu YT, Gu F, Huang YW, Liu J, Ruan J, Huang RL, Wang CM, Chen CL, Jadhav RR, Lai HC, Mutch DG, Goodfellow PJ, Thompson IM, Kirma NB, Huang TH. Promoter hypomethylation of EpCAM-regulated bone morphogenetic protein gene family in recurrent endometrial cancer. Clin Cancer Res. 2013 Nov 15; 19(22):6272-85.

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Wilken JA, Perez-Torres M, Nieves-Alicea R, Cora EM, Christensen TA, Baron AT, Maihle NJ. Shedding of soluble epidermal growth factor receptor (sEGFR) is mediated by a metalloprotease/fibronectin/integrin axis and inhibited by cetuximab. Biochemistry. 2013 Jul 02; 52(26):4531-40.

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