"Gene Products, nef" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.
| Descriptor ID |
D015693
|
| MeSH Number(s) |
D12.776.964.775.362 D12.776.964.925.500
|
| Concept/Terms |
Gene Products, nef- Gene Products, nef
- Gene Product, nef
- nef Gene Product
- nef Protein
- 3'-orf Protein
- 3' orf Protein
- nef Gene Products
|
Below are MeSH descriptors whose meaning is more general than "Gene Products, nef".
Below are MeSH descriptors whose meaning is more specific than "Gene Products, nef".
This graph shows the total number of publications written about "Gene Products, nef" by people in this website by year, and whether "Gene Products, nef" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2004 | 2 | 1 | 3 |
| 2005 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Gene Products, nef" by people in Profiles.
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McNamara RP, Costantini LM, Myers TA, Schouest B, Maness NJ, Griffith JD, Damania BA, MacLean AG, Dittmer DP. Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses. mBio. 2018 02 06; 9(1).
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Katkoori VR, Basson MD, Bond VC, Manne U, Bumpers HL. Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelial-to-mesenchymal transition in colon and breast cancers. Oncotarget. 2015 Sep 29; 6(29):27763-77.
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Raymond AD, Campbell-Sims TC, Khan M, Lang M, Huang MB, Bond VC, Powell MD. HIV Type 1 Nef is released from infected cells in CD45(+) microvesicles and is present in the plasma of HIV-infected individuals. AIDS Res Hum Retroviruses. 2011 Feb; 27(2):167-78.
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Bumpers HL, Huang MB, Powell M, Grizzle WE, Lillard JW, Okoli J, Bond VC. Effects of HIV-1 Nef, a cytotoxic viral protein, on the growth of primary colorectal cancer. Cancer Biol Ther. 2005 Jan; 4(1):65-9.
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Huang MB, Jin LL, James CO, Khan M, Powell MD, Bond VC. Characterization of Nef-CXCR4 interactions important for apoptosis induction. J Virol. 2004 Oct; 78(20):11084-96.
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James CO, Huang MB, Khan M, Garcia-Barrio M, Powell MD, Bond VC. Extracellular Nef protein targets CD4+ T cells for apoptosis by interacting with CXCR4 surface receptors. J Virol. 2004 Mar; 78(6):3099-109.
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Khan M, Jin L, Huang MB, Miles L, Bond VC, Powell MD. Chimeric human immunodeficiency virus type 1 (HIV-1) virions containing HIV-2 or simian immunodeficiency virus Nef are resistant to cyclosporine treatment. J Virol. 2004 Feb; 78(4):1843-50.
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Khan M, Garcia-Barrio M, Powell MD. Restoration of wild-type infectivity to human immunodeficiency virus type 1 strains lacking nef by intravirion reverse transcription. J Virol. 2001 Dec; 75(24):12081-7.
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Nerurkar VR, Wu Z, Dashwood WM, Woodward CL, Zhang M, Detels R, Yanagihara R. Complete nef gene sequence of HIV type 1 subtype B' from professional plasma donors in the People's Republic of China. AIDS Res Hum Retroviruses. 1998 Mar 20; 14(5):461-4.