Spiro Compounds

"Spiro Compounds" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cyclic compounds that include two rings which share a single atom (usually a carbon). The simplest example of this type of compound is Spiro[2.2]pentane, which looks like a bow tie.

Descriptor ID	D013141
MeSH Number(s)	D02.455.426.779 D04.711
Concept/Terms	Spiro Compounds Spiro Compounds Compounds, Spiro

Below are MeSH descriptors whose meaning is more general than "Spiro Compounds".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Hydrocarbons [D02.455]
Hydrocarbons, Cyclic [D02.455.426]
Spiro Compounds [D02.455.426.779]
Polycyclic Compounds [D04]
Spiro Compounds [D04.711]

Below are MeSH descriptors whose meaning is related to "Spiro Compounds".

Below are MeSH descriptors whose meaning is more specific than "Spiro Compounds".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Spiro Compounds" by people in this website by year, and whether "Spiro Compounds" was a major or minor topic of these publications.

Bar chart showing 14 publications over 12 distinct years, with a maximum of 2 publications in 2001 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	0	1
2001	2	0	2
2003	0	1	1
2007	1	0	1
2008	1	0	1
2009	1	0	1
2016	0	1	1
2017	1	1	2
2018	0	1	1
2020	1	0	1
2022	1	0	1
2024	1	0	1

Below are the most recent publications written about "Spiro Compounds" by people in Profiles.

Baiden P, LaBrenz CA, Broni MN, Baiden JF, Adepoju OE. Prevalence of youth experiencing homelessness and its association with suicidal thoughts and behaviors: Findings from a population-based study. Psychiatry Res. 2024 Apr; 334:115823.

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Yin H, Chen Y, Zhong Q, Zheng S, Wang G, He L. Design, synthesis, and antitumor study of a series of novel 1-Oxa-4-azaspironenone derivatives. Bioorg Med Chem Lett. 2022 10 15; 74:128925.

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Kommineni N, Nottingham E, Bagde A, Patel N, Rishi AK, Dev SRS, Singh M. Role of nano-lipid formulation of CARP-1 mimetic, CFM-4.17 to improve systemic exposure and response in osimertinib resistant non-small cell lung cancer. Eur J Pharm Biopharm. 2021 Jan; 158:172-184.

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Das P, Hasan MH, Mitra D, Bollavarapu R, Valente EJ, Tandon R, Raucher D, Hamme AT. Design, Synthesis, and Preliminary Studies of Spiro-isoxazoline-peroxides against Human Cytomegalovirus and Glioblastoma ?. J Org Chem. 2019 06 07; 84(11):6992-7006.

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Parodi-Rull?n RM, Soto-Prado J, Vega-Lugo J, Chapa-Dubocq X, D?az-Cordero SI, Javadov S. Divergent Effects of Cyclophilin-D Inhibition on the Female Rat Heart: Acute Versus Chronic Post-Myocardial Infarction. Cell Physiol Biochem. 2018; 50(1):288-303.

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Drew AE, Moradei O, Jacques SL, Rioux N, Boriack-Sjodin AP, Allain C, Scott MP, Jin L, Raimondi A, Handler JL, Ott HM, Kruger RG, McCabe MT, Sneeringer C, Riera T, Shapiro G, Waters NJ, Mitchell LH, Duncan KW, Moyer MP, Copeland RA, Smith J, Chesworth R, Ribich SA. Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma. Sci Rep. 2017 12 21; 7(1):17993.

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Dong S, VanGelder K, Shi ZC, Yu Y, Wu Z, Ferguson R, Guo ZZ, Tang H, Frie J, Fu Q, Gu X, Priest BT, Thomas-Fowlkes B, Weinglass A, Margulis M, Liu J, Pai LY, Hampton C, Haimbach RE, Owens K, Tong V, Xu S, Hu M, Zingaro GJ, Morissette P, Ehrhart J, Roy S, Sullivan K, Pasternak A. Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores. Bioorg Med Chem Lett. 2017 06 01; 27(11):2559-2566.

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Jang S, Lewis TS, Powers C, Khuchua Z, Baines CP, Wipf P, Javadov S. Elucidating Mitochondrial Electron Transport Chain Supercomplexes in the Heart During Ischemia-Reperfusion. Antioxid Redox Signal. 2017 07 01; 27(1):57-69.

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D?az-Balzac CA, V?zquez-Figueroa LD, Garc?a-Arrar?s JE. Novel markers identify nervous system components of the holothurian nervous system. Invert Neurosci. 2014 Sep; 14(2):113-25.

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Tony KA, Dabideen D, Li J, D?az-Hern?ndez MD, Jim?nez-Barbero J, Mootoo DR. Olefin metathesis-iodoetherification-dehydroiodination strategy for spiroketal subunits of polyether antibiotics. J Org Chem. 2009 Oct 16; 74(20):7774-80.

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