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Chuan (River) Xiao

TitleDr.
Faculty RankAssociate Professor
InstitutionUniversity of Texas at El Paso
Departmentchemistry
Address500 West University
Department of Chemistry
El Paso TX 79968
Phone9157478657
Fax9157475996
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    I am a structural biologist who has extensive experience working on virus structures. My lab combines X-ray crystallography and cryo-electron microscopy (cryo-EM) to determine virus structures in order to understand their assembly and infection mechanism. The virus systems that under investigation include common cold viruses and marine viruses. Besides studying structures of intact viruses, Dr. Xiao is currently also working with protein structures related to viral SUMOlyation, viral DNA repair and viral DNA topoisomerization. In addition to virology projects, my lab is also interested in working with structures related to circadian rhythm, antibodies agaisnt glycans, and plant photosystems.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sun W, Hou J, Zhou Y, Zhu T, Yuan Q, Wang S, Manshaii F, Song C, Lei X, Wu X, Kim H, Yu Y, Xiao C, Zhang H, Song Y, Sun D, Jia B, Zhou G, Zhao J. Amorphous FeSnOx Nanosheets with Hierarchical Vacancies for Room-Temperature Sodium-Sulfur Batteries. Angew Chem Int Ed Engl. 2024 May 24; e202404816. PMID: 38788189.
      Citations:    Fields:    
    2. Rodriguez G, Martinez GS, Negrete OD, Sun S, Guo W, Xie Y, Li L, Xiao C, Ross JA, Kirken RA. JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation. Int J Mol Sci. 2023 Jul 25; 24(15). PMID: 37569303.
      Citations:    Fields:    Translation:Cells
    3. Xiao CR. In Memory of Michael G. Rossmann: A Wise Man with a Forever Young Heart. Viruses. 2021 07 05; 13(7). PMID: 34372511.
      Citations:    Fields:    Translation:Humans
    4. Xian Y, Avila R, Pant A, Yang Z, Xiao C. The Role of Tape Measure Protein in Nucleocytoplasmic Large DNA Virus Capsid Assembly. Viral Immunol. 2021 Jan-Feb; 34(1):41-48. PMID: 33074779.
      Citations: 4     Fields:    Translation:AnimalsCells
    5. Xian Y, Xiao C. Current capsid assembly models of icosahedral nucleocytoviricota viruses. Adv Virus Res. 2020; 108:275-313. PMID: 33837719.
      Citations: 3     Fields:    Translation:Cells
    6. Xian Y, Moreno B, Miranda V, Vijay N, Nunez LC, Choi J, Quinones CS, Rios P, Chauhan N, Moriel KV, Ruelas NJ, Castaneda AE, Rodriguez RC, Amezaga BN, Azzam SZ, Xiao C. Thermal stability analyses of human PERIOD-2 C-terminal domain using dynamic light scattering and circular dichroism. PLoS One. 2020; 15(4):e0221180. PMID: 32320392.
      Citations:    Fields:    Translation:HumansCells
    7. Xian Y, Xiao C. The Structure of ASFV Advances the Fight against the Disease. Trends Biochem Sci. 2020 04; 45(4):276-278. PMID: 32169172.
      Citations: 14     Fields:    Translation:AnimalsCells
    8. Xiao C, Li X, Liu S, Sang Y, Gao SJ, Gao F. HIV-1 did not contribute to the 2019-nCoV genome. Emerg Microbes Infect. 2020; 9(1):378-381. PMID: 32056509.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    9. Ray S, Vazquez Reyes S, Xiao C, Sun J. Effects of membrane lipid composition on Mycobacterium tuberculosis EsxA membrane insertion: A dual play of fluidity and charge. Tuberculosis (Edinb). 2019 09; 118:101854. PMID: 31430698.
      Citations: 10     Fields:    Translation:HumansCells
    10. Xiao C, Fischer MG, Bolotaulo DM, Ulloa-Rondeau N, Avila GA, Suttle CA. Cryo-EM reconstruction of the Cafeteria roenbergensis virus capsid suggests novel assembly pathway for giant viruses. Sci Rep. 2017 07 14; 7(1):5484. PMID: 28710447.
      Citations: 18     Fields:    Translation:Cells
    11. Dou M, Lopez J, Rios M, Garcia O, Xiao C, Eastman M, Li X. A fully battery-powered inexpensive spectrophotometric system for high-sensitivity point-of-care analysis on a microfluidic chip. Analyst. 2016 Jun 21; 141(12):3898-903. PMID: 27143408.
      Citations: 13     Fields:    
    12. Jacquez P, Avila G, Boone K, Altiyev A, Puschhof J, Sauter R, Arigi E, Ruiz B, Peng X, Almeida I, Sherman M, Xiao C, Sun J. The Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen Pore. PLoS One. 2015; 10(6):e0130832. PMID: 26107617.
      Citations: 4     Fields:    Translation:HumansCells
    13. Acosta Y, Zhang Q, Rahaman A, Ouellet H, Xiao C, Sun J, Li C. Imaging cytosolic translocation of Mycobacteria with two-photon fluorescence resonance energy transfer microscopy. Biomed Opt Express. 2014 Nov 01; 5(11):3990-4001. PMID: 25426325.
      Citations:    
    14. Avila GA, Ramirez DH, Hildenbrand ZL, Jacquez P, Chiocca S, Sun J, Rosas-Acosta G, Xiao C. Expression and in vitro functional analyses of recombinant Gam1 protein. Protein Expr Purif. 2015 Jan; 105:47-53. PMID: 25450237.
      Citations:    Fields:    Translation:Cells
    15. Jacquez P, Lei N, Weigt D, Xiao C, Sun J. Expression and purification of the functional ectodomain of human anthrax toxin receptor 2 in Escherichia coli Origami B cells with assistance of bacterial Trigger Factor. Protein Expr Purif. 2014 Mar; 95:149-55. PMID: 24380801.
      Citations: 6     Fields:    Translation:Cells
    16. Xiao C, Rossmann MG. Structures of giant icosahedral eukaryotic dsDNA viruses. Curr Opin Virol. 2011 Aug; 1(2):101-9. PMID: 21909343.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    17. Hildenbrand ZL, Molugu SK, Herrera N, Ramirez C, Xiao C, Bernal RA. Hsp90 can accommodate the simultaneous binding of the FKBP52 and HOP proteins. Oncotarget. 2011 Jan-Feb; 2(1-2):43-58. PMID: 21378414.
      Citations: 19     Fields:    Translation:HumansCells
    18. Hildenbrand ZL, Molugu SK, Paul A, Avila GA, Herrera N, Xiao C, Cox MB, Bernal RA. High-yield expression and purification of the Hsp90-associated p23, FKBP52, HOP and SGTa proteins. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 15; 878(28):2760-4. PMID: 20829124.
      Citations: 2     Fields:    Translation:HumansCells
    19. Klose T, Kuznetsov YG, Xiao C, Sun S, McPherson A, Rossmann MG. The three-dimensional structure of Mimivirus. Intervirology. 2010; 53(5):268-73. PMID: 20551678.
      Citations: 26     Fields:    Translation:Cells
    20. Cherrier MV, Kostyuchenko VA, Xiao C, Bowman VD, Battisti AJ, Yan X, Chipman PR, Baker TS, Van Etten JL, Rossmann MG. An icosahedral algal virus has a complex unique vertex decorated by a spike. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11085-9. PMID: 19541619.
      Citations: 40     Fields:    Translation:Cells
    21. Xiao C, Kuznetsov YG, Sun S, Hafenstein SL, Kostyuchenko VA, Chipman PR, Suzan-Monti M, Raoult D, McPherson A, Rossmann MG. Structural studies of the giant mimivirus. PLoS Biol. 2009 Apr 28; 7(4):e92. PMID: 19402750.
      Citations: 86     Fields:    Translation:Cells
    22. Zauberman N, Mutsafi Y, Halevy DB, Shimoni E, Klein E, Xiao C, Sun S, Minsky A. Distinct DNA exit and packaging portals in the virus Acanthamoeba polyphaga mimivirus. PLoS Biol. 2008 May 13; 6(5):e114. PMID: 18479185.
      Citations: 76     Fields:    Translation:AnimalsCells
    23. Hafenstein S, Palermo LM, Kostyuchenko VA, Xiao C, Morais MC, Nelson CD, Bowman VD, Battisti AJ, Chipman PR, Parrish CR, Rossmann MG. Asymmetric binding of transferrin receptor to parvovirus capsids. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6585-9. PMID: 17420467.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    24. Rossmann MG, Arisaka F, Battisti AJ, Bowman VD, Chipman PR, Fokine A, Hafenstein S, Kanamaru S, Kostyuchenko VA, Mesyanzhinov VV, Shneider MM, Morais MC, Leiman PG, Palermo LM, Parrish CR, Xiao C. From structure of the complex to understanding of the biology. Acta Crystallogr D Biol Crystallogr. 2007 Jan; 63(Pt 1):9-16. PMID: 17164521.
      Citations: 7     Fields:    Translation:Cells
    25. Pokidysheva E, Zhang Y, Battisti AJ, Bator-Kelly CM, Chipman PR, Xiao C, Gregorio GG, Hendrickson WA, Kuhn RJ, Rossmann MG. Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN. Cell. 2006 Feb 10; 124(3):485-93. PMID: 16469696.
      Citations: 150     Fields:    Translation:HumansCells
    26. Xiao C, Chipman PR, Battisti AJ, Bowman VD, Renesto P, Raoult D, Rossmann MG. Cryo-electron microscopy of the giant Mimivirus. J Mol Biol. 2005 Oct 28; 353(3):493-6. PMID: 16185710.
      Citations: 53     Fields:    Translation:Cells
    27. Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG. The crystal structure of coxsackievirus A21 and its interaction with ICAM-1. Structure. 2005 Jul; 13(7):1019-33. PMID: 16004874.
      Citations: 46     Fields:    Translation:HumansCells
    28. Xiao C, Tuthill TJ, Bator Kelly CM, Challinor LJ, Chipman PR, Killington RA, Rowlands DJ, Craig A, Rossmann MG. Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor molecule. J Virol. 2004 Sep; 78(18):10034-44. PMID: 15331736.
      Citations: 11     Fields:    Translation:HumansCells
    29. Xiao C, Bator CM, Bowman VD, Rieder E, He Y, H?bert B, Bella J, Baker TS, Wimmer E, Kuhn RJ, Rossmann MG. Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1. J Virol. 2001 Mar; 75(5):2444-51. PMID: 11160747.
      Citations: 40     Fields:    Translation:HumansCells
    30. Xiao C, Xin H, Dong A, Sun C, Cao K. A novel calmodulin-like protein gene in rice which has an unusual prolonged C-terminal sequence carrying a putative prenylation site. DNA Res. 1999 Jun 30; 6(3):179-81. PMID: 10470849.
      Citations: 7     Fields:    Translation:AnimalsCells
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