"Phencyclidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
| Descriptor ID |
D010622
|
| MeSH Number(s) |
D03.383.621.699
|
| Concept/Terms |
Phencyclidine- Phencyclidine
- 1-(1-Phenylcyclohexyl)piperidine
- Angel Dust
- Dust, Angel
|
Below are MeSH descriptors whose meaning is more general than "Phencyclidine".
Below are MeSH descriptors whose meaning is more specific than "Phencyclidine".
This graph shows the total number of publications written about "Phencyclidine" by people in this website by year, and whether "Phencyclidine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2006 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Phencyclidine" by people in Profiles.
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Elsworth JD, Groman SM, Jentsch JD, Valles R, Shahid M, Wong E, Marston H, Roth RH. Asenapine effects on cognitive and monoamine dysfunction elicited by subchronic phencyclidine administration. Neuropharmacology. 2012 Mar; 62(3):1442-52.
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Rasmussen BA, O'Neil J, Manaye KF, Perry DC, Tizabi Y. Long-term effects of developmental PCP administration on sensorimotor gating in male and female rats. Psychopharmacology (Berl). 2007 Jan; 190(1):43-9.
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Lee E, Williams Z, Goodman CB, Oriaku ET, Harris C, Thomas M, Soliman KF. Effects of NMDA receptor inhibition by phencyclidine on the neuronal differentiation of PC12 cells. Neurotoxicology. 2006 Jul; 27(4):558-66.
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Sircar R, Soliman KF. Effects of postnatal PCP treatment on locomotor behavior and striatal D2 receptor. Pharmacol Biochem Behav. 2003 Mar; 74(4):943-52.
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Pag?n OR, Eterovic VA, Garcia M, Vergne D, Basilio CM, Rodr?guez AD, Hann RM. Cembranoid and long-chain alkanol sites on the nicotinic acetylcholine receptor and their allosteric interaction. Biochemistry. 2001 Sep 18; 40(37):11121-30.
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Eaton MJ, Labarca C, Eterov?c VA. M2 mutations of the nicotinic acetylcholine receptor increase the potency of the non-competitive inhibitor phencyclidine. J Neurosci Res. 2000 Jul 01; 61(1):44-51.
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Eterovic VA, Lu R, Eakin AE, Rodr?guez AD, Ferchmin PA. Determinants of phencyclidine potency on the nicotinic acetylcholine receptors from muscle and electric organ. Cell Mol Neurobiol. 1999 Dec; 19(6):745-57.
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Ulrich H, Ippolito JE, Pag?n OR, Eterovic VA, Hann RM, Shi H, Lis JT, Eldefrawi ME, Hess GP. In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14051-6.
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Hann RM, Pag?n OR, Gregory L, J?come T, Rodr?guez AD, Ferchmin PA, Lu R, Eterovic VA. Characterization of cembranoid interaction with the nicotinic acetylcholine receptor. J Pharmacol Exp Ther. 1998 Oct; 287(1):253-60.
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Eaton MJ, Pag?n OR, Hann RM, Eterovic VA. Differential effects of dimethyl sulfoxide on nicotinic acetylcholine receptors from mouse muscle and Torpedo electrocytes. Neurosci Lett. 1997 Jul 25; 230(3):163-6.