1-Methyl-4-phenylpyridinium
"1-Methyl-4-phenylpyridinium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death. The compound, which is related to PARAQUAT, has also been used as an herbicide.
| Descriptor ID |
D015655
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| MeSH Number(s) |
D03.383.725.762.550
|
| Concept/Terms |
1-Methyl-4-phenylpyridinium- 1-Methyl-4-phenylpyridinium
- 1 Methyl 4 phenylpyridinium
- 1-Methyl-4-phenylpyridine
- 1 Methyl 4 phenylpyridine
- N-Methyl-4-phenylpyridinium
- N-Methyl-4-phenylpyridine
- N Methyl 4 phenylpyridine
- 1-Methyl-4-phenylpyridinium Ion
- 1 Methyl 4 phenylpyridinium Ion
- Cyperquat
|
Below are MeSH descriptors whose meaning is more general than "1-Methyl-4-phenylpyridinium".
Below are MeSH descriptors whose meaning is more specific than "1-Methyl-4-phenylpyridinium".
This graph shows the total number of publications written about "1-Methyl-4-phenylpyridinium" by people in this website by year, and whether "1-Methyl-4-phenylpyridinium" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 1 | 0 | 1 |
| 2003 | 4 | 0 | 4 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "1-Methyl-4-phenylpyridinium" by people in Profiles.
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Mack N, Mazzio E, Badisa R, Soliman KFA. Metabolic Response to the Mitochondrial Toxin 1-Methyl-4-phenylpyridinium (MPP+) in LDH-A/B Double-knockout LS174T Colon Cancer Cells. Cancer Genomics Proteomics. 2021 May-Jun; 18(3 Suppl):385-405.
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Badisa RB, Mina DA, Latinwo LM, Soliman KF. Selective anticancer activity of neurotoxin 1-methyl-4-phenylpyridinium on non-small cell lung adenocarcinoma A549 cells. Anticancer Res. 2014 Oct; 34(10):5447-52.
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Mazzio E, Soliman KF. Whole genome expression profile in neuroblastoma cells exposed to 1-methyl-4-phenylpyridine. Neurotoxicology. 2012 Oct; 33(5):1156-69.
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Wang X, Su B, Liu W, He X, Gao Y, Castellani RJ, Perry G, Smith MA, Zhu X. DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease. Aging Cell. 2011 Oct; 10(5):807-23.
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Badisa RB, Darling-Reed SF, Soliman KF. The protective role of D-glucose against 1-methyl-4-phenylpyridinium ion (MPP+): induced mitochondrial dysfunction in C6 astroglial cells. Neurochem Res. 2010 Sep; 35(9):1413-21.
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Mazzio EA, Soliman YI, Soliman KF. Variable toxicological response to the loss of OXPHOS through 1-methyl-4-phenylpyridinium-induced mitochondrial damage and anoxia in diverse neural immortal cell lines. Cell Biol Toxicol. 2010 Dec; 26(6):527-39.
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Soliman Y, Jackson T, Mazzio E, Soliman KF. The effects of piroxicam in the attenuation of MPP+/MPTP toxicity in vitro and in vivo. Neurochem Res. 2009 Feb; 34(2):304-10.
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Williams ZR, Goodman CB, Soliman KF. Anaerobic glycolysis protection against 1-methy-4-phenylpyridinium (MPP+) toxicity in C6 glioma cells. Neurochem Res. 2007 Jun; 32(6):1071-80.
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Lee ES, Chen H, Charlton CG, Soliman KF. The role of phospholipid methylation in 1-methyl-4-phenyl-pyridinium ion (MPP+)-induced neurotoxicity in PC12 cells. Neurotoxicology. 2005 Dec; 26(6):945-57.
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Mazzio EA, Soliman KF. Effects of enhancing mitochondrial oxidative phosphorylation with reducing equivalents and ubiquinone on 1-methyl-4-phenylpyridinium toxicity and complex I-IV damage in neuroblastoma cells. Biochem Pharmacol. 2004 Mar 15; 67(6):1167-84.