Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.

Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene. 2016 04 28; 35(17):2186-96.

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subject areas

Animals
Cell Proliferation
Female
Gene Expression Regulation, Neoplastic
GRB2 Adaptor Protein
Humans
Mice
Oncogene Protein v-akt
Ovarian Neoplasms
Phosphatidylinositols
Phospholipase C gamma
Prognosis
PTEN Phosphohydrolase
Receptor, Fibroblast Growth Factor, Type 2
Signal Transduction

authors with profiles

Guillermo N Armaiz Pena

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