"Mecamylamine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.
| Descriptor ID |
D008464
|
| MeSH Number(s) |
D02.455.849.575.781.500
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Mecamylamine".
Below are MeSH descriptors whose meaning is more specific than "Mecamylamine".
This graph shows the total number of publications written about "Mecamylamine" by people in this website by year, and whether "Mecamylamine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 3 | 3 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mecamylamine" by people in Profiles.
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Mart?nez M, Espinoza VE, Garcia V, Uribe KP, Negishi K, Estevao IL, Carcoba LM, O'Dell LE, Khan AM, Mendez IA. Withdrawal from repeated nicotine vapor exposure increases somatic signs of physical dependence, anxiety-like behavior, and brain reward thresholds in adult male rats. Neuropharmacology. 2023 12 01; 240:109681.
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Cruz B, Ortegon S, Giner P, Matos-Ocasio F, Rodriguez-Crespo A, Uribe KP, Galindo KI, Serafine KM, Nazarian A, O'Dell LE. The emergence of insulin resistance following a chronic high-fat diet regimen coincides with an increase in the reinforcing effects of nicotine in a sex-dependent manner. Neuropharmacology. 2021 12 01; 200:108787.
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Jimenez T, Friedman T, Vadgama J, Singh V, Tucker A, Collazo J, Sinha S, Hikim AS, Singh R, Pervin S. Nicotine Synergizes with High-Fat Diet to Induce an Anti-Inflammatory Microenvironment to Promote Breast Tumor Growth. Mediators Inflamm. 2020; 2020:5239419.
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Nega S, Marquez P, Hamid A, Ahmad SM, Lutfy K. The role of pituitary adenylyl cyclase activating polypeptide in affective signs of nicotine withdrawal. J Neurosci Res. 2020 08; 98(8):1549-1560.
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Correa VL, Flores RJ, Carcoba LM, Arreguin MC, O'Dell LE. Sex differences in cholinergic systems in the interpeduncular nucleus following nicotine exposure and withdrawal. Neuropharmacology. 2019 11 01; 158:107714.
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Shao XM, L?pez-Vald?s HE, Liang J, Feldman JL. Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats. Sci Rep. 2017 12 05; 7(1):16974.
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Carcoba LM, Flores RJ, Natividad LA, O'Dell LE. Amino acid modulation of dopamine in the nucleus accumbens mediates sex differences in nicotine withdrawal. Addict Biol. 2018 09; 23(5):1046-1054.
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Pipkin JA, Cruz B, Flores RJ, Hinojosa CA, Carcoba LM, Ibarra M, Francis W, Nazarian A, O'Dell LE. Both nicotine reward and withdrawal are enhanced in a rodent model of diabetes. Psychopharmacology (Berl). 2017 05; 234(9-10):1615-1622.
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Singh SP, Chand HS, Gundavarapu S, Saeed AI, Langley RJ, Tesfaigzi Y, Mishra NC, Sopori ML. HIF-1a Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. PLoS One. 2015; 10(9):e0137757.
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Brown D, Ramlochansingh C, Manaye KF, Tizabi Y. Nicotine promotes survival of cells expressing amyloid precursor protein and presenilin: implication for Alzheimer's disease. Neurosci Lett. 2013 Feb 22; 535:57-61.