"Lovastatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.
| Descriptor ID |
D008148
|
| MeSH Number(s) |
D02.455.426.559.847.638.400 D04.615.638.400
|
| Concept/Terms |
Lovastatin- Lovastatin
- Mevinolin
- Monacolin K
- 6-Methylcompactin
- 6 Methylcompactin
|
Below are MeSH descriptors whose meaning is more general than "Lovastatin".
Below are MeSH descriptors whose meaning is more specific than "Lovastatin".
This graph shows the total number of publications written about "Lovastatin" by people in this website by year, and whether "Lovastatin" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Lovastatin" by people in Profiles.
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Lum CJ, Nakagawa K, Shohet RV, Seto TB, Taira DA. The Cost-Benefit Balance of Statins in Hawai'i: A Moving Target. Hawaii J Med Public Health. 2017 04; 76(4):99-102.
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Alarcon VB, Marikawa Y. Statins inhibit blastocyst formation by preventing geranylgeranylation. Mol Hum Reprod. 2016 05; 22(5):350-63.
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Ogunwobi OO, Beales IL. Statins inhibit proliferation and induce apoptosis in Barrett's esophageal adenocarcinoma cells. Am J Gastroenterol. 2008 Apr; 103(4):825-37.
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Crespo MJ, Quidgley JA. Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro. Pharmacology. 2006; 76(3):141-7.
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Sharma M, Sharma DR, Singh V, Panwar RB, Hira HS, Mohan B, Kumar N, Sharma SK, Gupta R. Evaluation of efficacy and safety of fixed dose lovastatin and niacin(ER) combination in asian Indian dyslipidemic patients: a multicentric study. Vasc Health Risk Manag. 2006; 2(1):87-93.
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Belcher J, Benghuzzi H, Franklin L, Cameron J, Tucci M. Comparison between mevinolin and PTH action on MG63 osteoblast-like cells. Biomed Sci Instrum. 2006; 42:267-72.
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Brandle M, Davidson MB, Schriger DL, Lorber B, Herman WH. Cost effectiveness of statin therapy for the primary prevention of major coronary events in individuals with type 2 diabetes. Diabetes Care. 2003 Jun; 26(6):1796-801.
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Urbina JA, Lazardi K, Marchan E, Visbal G, Aguirre T, Piras MM, Piras R, Maldonado RA, Payares G, de Souza W. Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. Antimicrob Agents Chemother. 1993 Mar; 37(3):580-91.