Histone Deacetylases

"Histone Deacetylases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.

Descriptor ID	D006655
MeSH Number(s)	D08.811.277.087.520
Concept/Terms	Histone Deacetylases Histone Deacetylases Deacetylases, Histone Histone Deacetylase Deacetylase, Histone HDAC Proteins Histone Deacetylase Complexes Histone Deacetylase Complexes Complexes, Histone Deacetylase Deacetylase Complexes, Histone Class I Histone Deacetylases Class I Histone Deacetylases Class II Histone Deacetylases Class II Histone Deacetylases

Below are MeSH descriptors whose meaning is more general than "Histone Deacetylases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Amidohydrolases [D08.811.277.087]
Histone Deacetylases [D08.811.277.087.520]

Below are MeSH descriptors whose meaning is related to "Histone Deacetylases".

Below are MeSH descriptors whose meaning is more specific than "Histone Deacetylases".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Histone Deacetylases" by people in this website by year, and whether "Histone Deacetylases" was a major or minor topic of these publications.

Bar chart showing 42 publications over 20 distinct years, with a maximum of 6 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2003	0	1	1
2004	1	0	1
2005	0	2	2
2006	1	0	1
2007	1	1	2
2008	1	2	3
2009	1	0	1
2010	1	0	1
2011	1	1	2
2013	1	0	1
2014	1	2	3
2015	4	2	6
2016	1	1	2
2017	3	1	4
2018	1	1	2
2019	1	1	2
2020	2	2	4
2021	2	0	2
2024	0	1	1

Below are the most recent publications written about "Histone Deacetylases" by people in Profiles.

Bornes KE, Moody MA, Huckaba TM, Benz MC, McConnell EC, Foroozesh M, Barnes VH, Collins-Burow BM, Burow ME, Watt TJ, Toro TB. Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off-target effects. FEBS Open Bio. 2025 Jan; 15(1):94-107.

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Toro TB, Swanier JS, Bezue JA, Broussard CG, Watt TJ. Lysine Deacetylase Substrate Selectivity: A Dynamic Ionic Interaction Specific to KDAC8. Biochemistry. 2021 08 24; 60(33):2524-2536.

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Tilekar K, Hess JD, Upadhyay N, Bianco AL, Schweipert M, Laghezza A, Loiodice F, Meyer-Almes FJ, Aguilera RJ, Lavecchia A, C S R. Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPAR? and HDACs: Design, Synthesis, and Investigations of their In Vitro and In Vivo Antitumor Effects. J Med Chem. 2021 05 27; 64(10):6949-6971.

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Ranganna K, Selvam C, Shivachar A, Yousefipour Z. Histone Deacetylase Inhibitors as Multitarget-Directed Epi-Drugs in Blocking PI3K Oncogenic Signaling: A Polypharmacology Approach. Int J Mol Sci. 2020 Nov 02; 21(21).

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Pajarillo E, Johnson J, Rizor A, Nyarko-Danquah I, Adinew G, Bornhorst J, Stiboller M, Schwerdtle T, Son DS, Aschner M, Lee E. Astrocyte-specific deletion of the transcription factor Yin Yang 1 in murine substantia nigra mitigates manganese-induced dopaminergic neurotoxicity. J Biol Chem. 2020 11 13; 295(46):15662-15676.

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Lin J, Hung FY, Ye C, Hong L, Shih YH, Wu K, Li QQ. HDA6-dependent histone deacetylation regulates mRNA polyadenylation in Arabidopsis. Genome Res. 2020 10; 30(10):1407-1417.

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Upadhyay N, Tilekar K, J?nsch N, Schweipert M, Hess JD, Henze Macias L, Mrowka P, Aguilera RJ, Choe JY, Meyer-Almes FJ, Ramaa CS. Discovery of novel N-substituted thiazolidinediones (TZDs) as HDAC8 inhibitors: in-silico studies, synthesis, and biological evaluation. Bioorg Chem. 2020 07; 100:103934.

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Mathew OP, Ranganna K, Mathew J, Zhu M, Yousefipour Z, Selvam C, Milton SG. Cellular Effects of Butyrate on Vascular Smooth Muscle Cells are Mediated through Disparate Actions on Dual Targets, Histone Deacetylase (HDAC) Activity and PI3K/Akt Signaling Network. Int J Mol Sci. 2019 Jun 14; 20(12).

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Zhang Z, Garzotto M, Davis EW, Mori M, Stoller WA, Farris PE, Wong CP, Beaver LM, Thomas GV, Williams DE, Dashwood RH, Hendrix DA, Ho E, Shannon J. Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial. Nutr Cancer. 2020; 72(1):74-87.

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Mazzio EA, Soliman KFA. Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A. Cancer Genomics Proteomics. 2018 Sep-Oct; 15(5):349-364.

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