"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
| Descriptor ID |
D003609
|
| MeSH Number(s) |
D03.633.300.200 D04.345.566.252 D12.644.641.252
|
| Concept/Terms |
Cosmegen- Cosmegen
- Cosmegen Lyovac
- Lyovac, Cosmegen
- Lyovac-Cosmegen
- Lyovac Cosmegen
- LyovacCosmegen
|
Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".
This graph shows the total number of publications written about "Dactinomycin" by people in this website by year, and whether "Dactinomycin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dactinomycin" by people in Profiles.
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Humphrey-Johnson A, Abukalam R, Eltom SE. Stability of the aryl hydrocarbon receptor and its regulated genes in the low activity variant of Hepa-1 cell line. Toxicol Lett. 2015 Mar 04; 233(2):59-67.
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Vogt RR, Unda R, Yeh LC, Vidro EK, Lee JC, Tsin AT. Bone morphogenetic protein-4 enhances vascular endothelial growth factor secretion by human retinal pigment epithelial cells. J Cell Biochem. 2006 Aug 01; 98(5):1196-202.
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Abbas T, White D, Hui L, Yoshida K, Foster DA, Bargonetti J. Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta. J Biol Chem. 2004 Mar 12; 279(11):9970-7.
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Das SK, Chatterjee D, Uddin M. Induction of pro-renin converting enzyme mk9 by thyroid hormone in the guinea-pig liver. Biochem Biophys Res Commun. 2002 Apr 26; 293(1):412-5.
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Jenab S, Morris PL. Interleukin-6 regulation of kappa opioid receptor gene expression in primary sertoli cells. Endocrine. 2000 Aug; 13(1):11-5.
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Garibay-Tupas JL, Bao S, Kim MT, Tashima LS, Bryant-Greenwood GD. Isolation and analysis of the 3'-untranslated regions of the human relaxin H1 and H2 genes. J Mol Endocrinol. 2000 Apr; 24(2):241-52.
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Romero N, Jim?nez BD, Cadilla CL. Insulin and phorbol ester regulation of gene 33 expression in CHO cells. P R Health Sci J. 1999 Sep; 18(3):257-65.
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Rogers PD, Jenkins JK, Chapman SW, Ndebele K, Chapman BA, Cleary JD. Amphotericin B activation of human genes encoding for cytokines. J Infect Dis. 1998 Dec; 178(6):1726-33.
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Nangia-Makker P, Ochieng J, Christman JK, Raz A. Regulation of the expression of galactoside-binding lectin during human monocytic differentiation. Cancer Res. 1993 Oct 15; 53(20):5033-7.
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Mukherjee S, Nag S, Das SK. Gestational variation of glycerophosphate acyltransferase activity in maternal guinea pig lung and possible role of thyroid hormone in its de novo synthesis. Exp Lung Res. 1990 Sep-Oct; 16(5):481-8.