Cystathionine beta-Synthase
"Cystathionine beta-Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.
| Descriptor ID |
D003541
|
| MeSH Number(s) |
D08.811.520.241.300.200
|
| Concept/Terms |
Cystathionine beta-Synthase- Cystathionine beta-Synthase
- Cystathionine beta Synthase
- beta-Synthase, Cystathionine
- Serine Sulfhydrase
- Sulfhydrase, Serine
- Cystathionine Synthetase
- Synthetase, Cystathionine
- beta-Thionase
- beta Thionase
|
Below are MeSH descriptors whose meaning is more general than "Cystathionine beta-Synthase".
Below are MeSH descriptors whose meaning is more specific than "Cystathionine beta-Synthase".
This graph shows the total number of publications written about "Cystathionine beta-Synthase" by people in this website by year, and whether "Cystathionine beta-Synthase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cystathionine beta-Synthase" by people in Profiles.
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Kawahara B, Ramadoss S, Chaudhuri G, Janzen C, Sen S, Mascharak PK. Carbon monoxide sensitizes cisplatin-resistant ovarian cancer cell lines toward cisplatin via attenuation of levels of glutathione and nuclear metallothionein. J Inorg Biochem. 2019 02; 191:29-39.
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Sen S, Kawahara B, Mahata SK, Tsai R, Yoon A, Hwang L, Hu-Moore K, Villanueva C, Vajihuddin A, Parameshwar P, You M, Bhaskar DL, Gomez O, Faull KF, Farias-Eisner R, Chaudhuri G. Cystathionine: A novel oncometabolite in human breast cancer. Arch Biochem Biophys. 2016 08 15; 604:95-102.
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Sen S, Kawahara B, Gupta D, Tsai R, Khachatryan M, Roy-Chowdhuri S, Bose S, Yoon A, Faull K, Farias-Eisner R, Chaudhuri G. Role of cystathionine ?-synthase in human breast Cancer. Free Radic Biol Med. 2015 Sep; 86:228-38.
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Kulkarni-Chitnis M, Njie-Mbye YF, Mitchell L, Robinson J, Whiteman M, Wood ME, Opere CA, Ohia SE. Inhibitory action of novel hydrogen sulfide donors on bovine isolated posterior ciliary arteries. Exp Eye Res. 2015 May; 134:73-9.
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Christie AE, Fontanilla TM, Roncalli V, Cieslak MC, Lenz PH. Diffusible gas transmitter signaling in the copepod crustacean Calanus finmarchicus: identification of the biosynthetic enzymes of nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) using a de novo assembled transcriptome. Gen Comp Endocrinol. 2014 Jun 01; 202:76-86.
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Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. Mechanism of action of hydrogen sulfide on cyclic AMP formation in rat retinal pigment epithelial cells. Exp Eye Res. 2012 May; 98:16-22.
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Kulkarni M, Njie-Mbye YF, Okpobiri I, Zhao M, Opere CA, Ohia SE. Endogenous production of hydrogen sulfide in isolated bovine eye. Neurochem Res. 2011 Aug; 36(8):1540-5.
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Ohia SE, Opere CA, Monjok EM, Kouamou G, Leday AM, Njie-Mbye YF. Role of hydrogen sulfide production in inhibitory action of L-cysteine on isolated porcine irides. Curr Eye Res. 2010 May; 35(5):402-7.
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Monjok EM, Kulkarni KH, Kouamou G, McKoy M, Opere CA, Bongmba ON, Njie YF, Ohia SE. Inhibitory action of hydrogen sulfide on muscarinic receptor-induced contraction of isolated porcine irides. Exp Eye Res. 2008 Dec; 87(6):612-6.
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Dwyer BE, Raina AK, Perry G, Smith MA. Homocysteine and Alzheimer's disease: a modifiable risk? Free Radic Biol Med. 2004 Jun 01; 36(11):1471-5.