Cystathionine beta-Synthase

"Cystathionine beta-Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.

Descriptor ID	D003541
MeSH Number(s)	D08.811.520.241.300.200
Concept/Terms	Cystathionine beta-Synthase Cystathionine beta-Synthase Cystathionine beta Synthase beta-Synthase, Cystathionine Serine Sulfhydrase Sulfhydrase, Serine Cystathionine Synthetase Synthetase, Cystathionine beta-Thionase beta Thionase

Below are MeSH descriptors whose meaning is more general than "Cystathionine beta-Synthase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Carbon-Oxygen Lyases [D08.811.520.241]
Hydro-Lyases [D08.811.520.241.300]
Cystathionine beta-Synthase [D08.811.520.241.300.200]

Below are MeSH descriptors whose meaning is related to "Cystathionine beta-Synthase".

Below are MeSH descriptors whose meaning is more specific than "Cystathionine beta-Synthase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cystathionine beta-Synthase" by people in this website by year, and whether "Cystathionine beta-Synthase" was a major or minor topic of these publications.

Bar chart showing 10 publications over 9 distinct years, with a maximum of 2 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2008	0	1	1
2010	0	1	1
2011	0	1	1
2012	0	1	1
2014	0	1	1
2015	0	1	1
2019	1	0	1
2020	1	1	2

Below are the most recent publications written about "Cystathionine beta-Synthase" by people in Profiles.

Li X, Bu S, Pan RR, Zhou C, Qu K, Ying X, Zhong J, Xiao J, Yuan Q, Zhang S, Tipton L, Wang Y, Deng Y, Duan S. The values of AHCY and CBS promoter methylation on the diagnosis of cerebral infarction in Chinese Han population. BMC Med Genomics. 2020 11 02; 13(1):163.

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Dillon KM, Carrazzone RJ, Matson JB, Kashfi K. The evolving landscape for cellular nitric oxide and hydrogen sulfide delivery systems: A new era of customized medications. Biochem Pharmacol. 2020 06; 176:113931.

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Jeddi S, Gholami H, Gheibi S, Kashfi K, Ghasemi A. Altered gene expression of hydrogen sulfide-producing enzymes in the liver and muscles tissues of hyperthyroid rats. J Cell Physiol. 2019 08; 234(10):17937-17945.

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Kawahara B, Ramadoss S, Chaudhuri G, Janzen C, Sen S, Mascharak PK. Carbon monoxide sensitizes cisplatin-resistant ovarian cancer cell lines toward cisplatin via attenuation of levels of glutathione and nuclear metallothionein. J Inorg Biochem. 2019 02; 191:29-39.

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Sen S, Kawahara B, Mahata SK, Tsai R, Yoon A, Hwang L, Hu-Moore K, Villanueva C, Vajihuddin A, Parameshwar P, You M, Bhaskar DL, Gomez O, Faull KF, Farias-Eisner R, Chaudhuri G. Cystathionine: A novel oncometabolite in human breast cancer. Arch Biochem Biophys. 2016 08 15; 604:95-102.

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Sen S, Kawahara B, Gupta D, Tsai R, Khachatryan M, Roy-Chowdhuri S, Bose S, Yoon A, Faull K, Farias-Eisner R, Chaudhuri G. Role of cystathionine ?-synthase in human breast Cancer. Free Radic Biol Med. 2015 Sep; 86:228-38.

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Kulkarni-Chitnis M, Njie-Mbye YF, Mitchell L, Robinson J, Whiteman M, Wood ME, Opere CA, Ohia SE. Inhibitory action of novel hydrogen sulfide donors on bovine isolated posterior ciliary arteries. Exp Eye Res. 2015 May; 134:73-9.

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Christie AE, Fontanilla TM, Roncalli V, Cieslak MC, Lenz PH. Diffusible gas transmitter signaling in the copepod crustacean Calanus finmarchicus: identification of the biosynthetic enzymes of nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) using a de novo assembled transcriptome. Gen Comp Endocrinol. 2014 Jun 01; 202:76-86.

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Njie-Mbye YF, Kulkarni M, Opere CA, Ohia SE. Mechanism of action of hydrogen sulfide on cyclic AMP formation in rat retinal pigment epithelial cells. Exp Eye Res. 2012 May; 98:16-22.

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Kulkarni M, Njie-Mbye YF, Okpobiri I, Zhao M, Opere CA, Ohia SE. Endogenous production of hydrogen sulfide in isolated bovine eye. Neurochem Res. 2011 Aug; 36(8):1540-5.

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